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简介：RecognitionofDNAdamageisacriticalstepforDNAdamage-mediatedcellularresponse.XPCisanimportantDNAdamagerecognitionproteininvolvedinnucleotideexcisionrepair(NER).WehavestudiedtheXPCproteinincisplatinDNAdamagingtreatment-mediatedcellularresponse.ComparisonofthemicroarraydatafrombothnormalandXPCdefectivehumanfibroblastsidentified861XPC-responsivegenesinthecisplatintreatment(withminimumfoldchange≥1.5).Thecellcycleandcellproliferation-relatedgenesarethemostaffectedgenesbytheXPCdefectinthetreatment.Manyothercellularfunctiongenes,especiallytheDNArepairandsignaltransduction-relatedgenes,werealsoaffectedbytheXPCdefectinthetreatment.Tovalidatethemicroarraydata,thetranscriptionlevelsofsomemicroarray-identifiedgeneswerealsodeterminedbyanRT-PCRbasedrealtimePCRassay.TherealtimePCRresultsareconsistentwiththemicroarraydataformostofthetestedgenes,indicatingthereliabilityofthemicroarraydata.Tofurthervalidatethemicroarraydata,thecisplatintreatment-mediatedcaspase-3activationwasalsodetermined.TheWesternblothybridizationresultsindicatethattheXPCdefectgreatlyattenuatesthecisplatintreatment-mediatedCaspase-3activation.Weelucidatedtheroleofp53proteinintheXPCproteinDNAdamagerecognition-mediatedsignalingprocess.TheXPCdefectreducesthecisplatintreatment-mediatedp53response.TheseresultssuggestthattheXPCproteinplaysanimportantroleinthecisplatintreatment-mediatedcellularresponse.Itmayalsosuggestapossiblemechanismofcancercelldrugresistance.

简介：介绍了S函数的基础理论和利用S函数对Simulink中所没有的模块进行设计的方法,并采用此方法对RDC模块进行了具体的设计,通过仿真实验,验证了该方法的正确性.

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简介：摘要：为了更好地指导人们对 P&H4100XPC电铲提升电机进行正确 调整， 经过现场多次实践，查阅相关资料，全面介绍了提升电机的调整步骤，重点阐释了轴向位移、径向位移两个方面的调整并举实例说明，讨论了轴向位移和径向位移的调整顺序，结果表明精确调整可以延长 电机和联轴器的使用寿命， P&H4100XPC电铲提升电机安装完毕后必须进项正确地调整。

简介：对于选择一部“娱乐”DC，每个人都有自己的主张，但性能，耐用性与酷炫造型这三大原则，相信都会获得一致认同。这已经是自己第N+1部将要规划、装配的电脑了，不同的是，它将作为自己书桌下蒙尘的老奔…的替代者。你知道，选择越多，体验越多，你就越难以取舍。很多时候．购买新机只能被称为“升级”，而“换代”一说还真不是那么经得起推敲。