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简介：目的调查研究464例体检者体质量、血脂、血尿酸、血糖的水平及其关系,为制定合理的预防心脑血管疾病和糖尿病的措施提供参考依据。方法对464例体检者资料进行整理分析,按性别、年龄分组比较体质量指数（BMI）和血脂、血尿酸、血糖的水平及相关关系;按BMI分为肥胖组和非肥胖组,比较两组之间血脂、血尿酸、血糖的水平;进一步按性别、BMI比较两组之间血脂、血尿酸、血糖的水平。结果在464例体检者中男性血清尿酸显著高于女性,差异有统计学意义（P〈0.01）。血脂、血糖不同性别,不同年龄之间也有差异。肥胖组的血脂、血尿酸、血糖的水平显著高于非肥胖组,差异有统计学意义（P〈0.01）,BMI与血脂、血糖、血尿酸、年龄之间呈正相关,差异有统计学意义（P〈0.01）。男性肥胖者比例高于女性,差异有统计学意义（P〈0.01）。结论肥胖影响血脂、血尿酸、血糖代谢,降低体质量对预防心脑血管疾病和糖尿病有重要意义。

简介：2006年，肥西县被确定为“中国农村地区癫痫防治管理项目县”，并于2006年4月份启动项目工作，截止2007年底共人组管理464例。现将全县464例惊厥型癫痫患者资料进行分析，报告如下。

简介：AbstractImportance:As the most common subtype of pediatric rhabdomyosarcoma (RMS), the prognosis of embryonal RMS has rarely been investigated solely.Objective:To perform a population-based study to characterize the prognosis of embryonal RMS in children and adolescents.Methods:Demographic and clinical features were retrospectively evaluated in selected patients with embryonal RMS registered in the Surveillance, Epidemiology, and End Results (SEER) program from 1988 to 2016. Survival curves were compared using the log-rank test. A multivariate Cox proportional hazards model was developed to assess the impact of each factor on the overall survival. A nomogram was constructed based on the results of Cox regression model.Results:A total of 464 patients were included in the analysis, among which 64.6% were male and 70.2% were white patients. About 38.6% and 26.3% of the patients were at 1-4 years and 5-9 years, respectively. Cox analysis showed that patients at age group 5-9 years had the lowest risk of mortality (hazard ratio [HR], 0.277; 95% confidential interval [CI], 0.123-0.620), compared with patients diagnosed at less than 1-year-old, and age group 1-4 years had the second-best prognosis. Patients having distant tumors had significantly higher mortality risk (HR, 4.842; 95% CI, 2.804-8.362) than the patients with localized tumor. Compared with receiving no surgery or radiotherapy, receiving any combination of surgery and radiotherapy would lower the risk of mortality significantly (for surgery without radiotherapy: HR, 0.418; for radiotherapy without surgery: HR, 0.405; and for surgery plus radiotherapy: HR, 0.410).Interpretation:Age, stage at diagnosis, and treatment received were found to be the most important predictors of the overall survival of pediatric embryonal RMS.

简介：摘要目的通过米非司酮配伍米索前列醇终止早孕临床观察，效果良好。方法回顾性分析2011年1月1日至2012年2月29日早孕药流464人次。结果464人次早孕药流、胚胎完整排出358例(77.15%)，清宫106例(22.85%)，成功率100%，无并发症及意外发生。结论用米非司酮配伍米索前列醇终止早孕临床普遍应用，药效肯定。医务人员加强责任心，严密观察，效果良好。

简介：摘要目的了解大庆地区解脲、人型支原体感染情况及药物敏感试验。方法选择来我院就诊的464例患者，无菌操作采集标本后，接种到支原体培养、鉴定药敏培养基中，于37℃培养24h、48h后分别观察记录结果。结果在464例患者中，阳性标本160例，占34.5%。其中单纯解脲支原体（Uu）阳性114例，占阳性总数71.2%；单纯人型支原体（Mh）阳性19株，占阳性总数11.9%；解脲与人型混合阳性27株，占阳性总数16.9%。且在阳性标本的药敏试验中，交沙霉素、克拉霉素药物敏感率较高。结论在支原体感染中，单纯解脲支原体感染率较高，并且交沙霉素、克拉霉素、美满霉素对治疗支原体感染有效，临床有必要做支原体培养及药敏试验。

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简介：乙酰羟基酸合成酶(AHAS)是磺酰脲类、咪唑啉酮类、三唑嘧啶磺酰胺类及水杨酸类除草剂的作用靶标,大田使用中杂草对这几类除草剂产生抗性的主要因素是AHAS酶的突变.利用大肠杆菌AHASⅡ中464位的色氨酸突变体(W464A、W464F、W464L、W464Y),研究了野生型和突变酶对商品化除草剂(氯嘧磺隆、氯磺隆、咪唑乙烟酸、咪唑喹啉酸)以及烷硫基磺酰脲的敏感性.野生型E.coliAHASⅡ对这些化合物的抑制作用较为敏感,而突变酶对其呈现出不同程度的抗性,使商品化除草剂的抑制常数增加了10～1.0×104倍不等,烷硫基磺酰脲的抑制常数增加幅度较小.烷硫基磺酰脲1a对W464L突变酶的高抑制活性,暗示着发展针对靶酶抗性的除草剂的可能性.