简介：Thepathophysiologyoftinnitusispoorlyunderstoodandtreatmentsareoftenunsuccessful.Anumberofanimalmodelshavebeendevelopedinordertogainabetterunderstandingoftinnitus.Agreatdealhasbeenlearnedfromthesemodelsregardingtheelectrophysiologicalandneuroanatomicalcorrelatesoftinnitusfollowingexposuretonoiseorototoxicdrugs.Reliablebehavioraldataisimportantfordeterminingwhethersuchelectrophysiologicalorneuroanatomicalchangesareindeedrelatedtotinnitus.Ofthemanydocumentedtinnitusanimalbehavioralparadigms,theacousticstartlereflexhadbeenproposedasasimplemethodtoidentifythepresenceorabsenceoftinnitus.Severalbehavioralmodelsbasedonconditionedresponsesuppressionparadigmshavealsobeendeveloped.Inadditiontodeterminingthepresenceorabsenceoftinnitus,someofthebehavioralparadigmshaveprovidedsignsoftheonset,frequency,andintensityoftinnitusinanimals.Althoughnoneofthesebehavioralmodelshavebeenprovedtobeaperfectmodel,thesestudiesprovideusefulinformationonunderstandingtheneuralmechanismsunderlyingtinnitus.
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