简介：AbstractImportance:There is a high incidence of iron deficiency in children worldwide. Notably, however, while iron deficiency is the most common cause of anemia, little is known about the prevalence and different types of iron deficiency in neuroblastoma patients.Objective:The aim of the present study was to investigate the prevalence of iron deficiency in patients newly diagnosed with neuroblastoma.Methods:A total of 195 newly diagnosed neuroblastoma patients from November 2015 to January 2018 were analyzed retrospectively. The survival analysis was estimated by the Kaplan-Meier method.Results:Of the 195 neuroblastoma patients included in the study, 121 (62.1%) had iron deficiency, 55 (28.2%) had absolute iron deficiency, and 66 (33.9%) had functional iron deficiency. Being aged ≥ 18 months, tumor originating in the abdomen, International Neuroblastoma Risk Group Staging System M, high-risk neuroblastoma, lactate dehydrogenase ≥ 1500 U/L, neuron-specific enolase ≥ 100 U/L, unfavorable histologic category, MYCN amplification, chromosome 1p loss, and bone marrow metastasis were associated with significantly higher rates of functional iron deficiency (P < 0.05).Interpretation:Functional iron deficiency at the time of initial neuroblastoma diagnosis predicted lower event-free survival. Long-term effects of iron supplementation in neuroblastoma patients with different types of iron deficiency need to be further studied.

简介：AbstractBackgrounds:Previous surveys have found that children with iron deficiency (ID) were likely to suffer from early childhood caries (ECC). We aimed to assess the scientific evidence about whether ID is intrinsically related to ECC.Methods:The medical subject headings (MeSH) terms and free words were searched on PubMed, Web of Science, Cochrane, China National Knowledge Infrastructure, Wanfang, and the Database for Chinese Technical Periodicals from March 2020 to September 2020. Two researchers independently screened the articles. Data extraction and cross-checking were performed for the studies that met the inclusion criteria. Meta-analysis was performed using the Cochrane Collaboration’s Review Manager 5.3 software.Results:After excluding duplication and irrelevant literature, 12 case-control studies were included in the study. The meta-analysis demonstrated that children with ECC were more likely to have ID (odds ratio [OR] = 2.63, 95% confidence interval [CI]: [1.85, 3.73], P < 0.001). There was no statistically significant association found between the level of serum ferritin and ECC (weighted mean difference (WMD) = -5.80, 95% CI: [-11.97, 0.37], P= 0.07). Children with ECC were more likely to have iron-deficiency anemia (OR = 2.74, 95% CI: [2.41,3.11], P < 0.001). The hemoglobin (HGB) levels in the ECC group were significantly lower compared with that in the ECC-free group (WMD = -9.96, 95% CI: [-15.45, -4.46], P = 0.0004). The mean corpuscular volume (MCV) levels in the ECC group were significantly lower compared with that in the ECC-free group (WMD = -3.72, 95% CI: [-6.65, -0.79], P= 0.01).Conclusions:ID was more prevalent in children with ECC, and the markers of iron status in the ECC group, such as serum ferritin, HGB, and MCV, were relatively lower than the ECC-free group.

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简介：下面五幅小图中有一幅不属于上面的大图，你找到了吗？

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简介：ProfessorYuZongsenofBeijingUniver-sityofScienceandTechnologyhassum-marizedtheworksconcerningREadditioninironandsteelinlastfourtofiveyearsandwroteapaperentitled“Re-searchontheApplicationofRareEarthsinIronandSteelinResentYears”,whichwaspresentedinJ.Chin.RESoc.Vol.8No.2(1990)(EnglishEdition).Theauthorshowedmanydataoffree

简介：TherearetwomaintypesofirondepositsintheMiddle-LowerYangtzeValleydistrict.Bothofthemunderwentpost-magmatichydrothermalprocessesduringoreformation.Ironinthehydrothermalorebodieswasderivedlargelythroughmobilizationfromsubstantiallyconsolidateddiroiticintrusives.Wall-rochalterationzonationindicatesthatiron-mobilizinghydrothermalfluidsevolvedinatrendofdecreasingalkalinity,whichissuggestedbyregularlydistributedwall-rockalterationsformedbyiron-mobilizinghydrothermalfluidsandisincontradictionwiththecurrentchloride,chloridecomplexandbicarbonatemodelsforironmobilization.ThecloseassociationofcarbonatizationwithironoresandthehighconcentrationsofreducedgasessuchasCO,CH4andH2influidinclusionssuggestthatironismostprobablytransportedintheformofironcarbonylsduringpost-magmatichydrothermalprocesses.Inthelightoftheironcarbonylmobilizationmodel,explanationsaremadeoftheconstraintsonoresofsomegeologicfactorssuchasmelanocraticalteration,carbonatization,carbonatestrata,structuralfractures,cyptoexplosivepipesandembryoores.

简介：Recentstudieshaverevealedthatthepropertyofdrugismainlyassociatedwiththebody'ssubstanceandenergyme-tabolism.ThepresentstudyaimedtoevaluatethedrugpropertyofPoria,calledFuling(FL)intraditionalChinesemedicine(TCM),intermsofitseffectsonthesubstanceandenergymetabolisminratmodelsofcold-deficiencyandheat-deficiencysyndromes,comparedwithAconitiLateralisRadixPraeparaia,calledFuzi(FZ)inTCM,withhotproperty,andAnemarrhenaeRhizoma,calledZhimu(ZM)inTCM,withcoldproperty,asreferencedrugs,respectively.Theappearancescore,toeandrectaltemperaturesoftheanimalstreatedwereassessedatdifferenttimepoints.Severalindicesinvivocorrelatedwithsubstanceandenergymetabolism(glucokinas,phosphoglyceratekinase,cytochromecreductase,cytochromecoxydase,andNa^+-K^+-ATPase),endocrinesystem(triiodothyronine,thyroxine,and17-hydroxycorticosteroid),nervoussystem(acetylcholinesterase),andcyclicnucleotidesystemweredetermined.Thechangesinappearancescoreandindicesinvivosuggestedthesuccessfulestablishmentofcold-deficiencyandheat-deficiencysyndromemodels.FZreversedthedecreasedlevelsofindices(substanceandenergymetabolismandendocrinesystem)andalleviatedthesyndromeofcold-deficiencymodel,andZMshowedobviouslytherapeuticeffectonheat-deficiencysyndrome(appearancescore,substanceandenergymetabolism,andendocrinesystem).FLcouldalleviatecold-deficiencysyndromeandraisethedecreasedlevelsofglucokinas,phosphoglyceratekinase,cytochromecreductaseandtriiodothyronineincold-deficiencymodel,buthadnosignificanteffectonheat-deficiencysyndrome.DrugpropertyofFLwasinferredastrendingto"flatandwarm",whichstillneedfurtherstudy.Itwasadvisabletoadoptbothcold-deficiencyandheat-deficiencymodelstostudythedrugswith"flat"property.

简介：ThelargestREconsumerinChinaisthefoundryindustry.Statisticsshowthat46.3%ofthetotalREconsumptionwasusedascastironadditionsin1988.TheamountofREappliedincastinginallthesteelplantsincreasedtwiceinthepasttenyears.Manysparepartsformetallurgicalma-chineryincludingwearingpiates,grin-dingballs,sludgepumps,carriersofsin-teringmachine,ingotmolds,rolls,draw-ingheads,guides,pipes,cylindercasings,gears,etc.,aremadeoutofRE-treatednodular-,vermicular-,andgraycastiron,

简介：Nickel-irontypecastironelectrodesarewidelyusedforweldingQT600-3nodulariron.Nevertheless,theresearchworkhasdemonstratedthatthestrengthoftheseheterogeneousweldedjointsislow.Inthispaper,theuni-axialtensionofthejointsisstudiedbytheMoirefringemethod,andthedis-placement,strainandstressinthetotalfieldsareobtaind.Basedontheunevendistributionofstrainandstress,thereasonofcrackinitiationandpropagationisdiscussed.Throughexaminingtheappearanceofthefracturebyscanningelec-tronmicroscope,alotofsphericalsubstancesdistributedonthefracturesurfacearefound,whichmaybeanotherreasonleadingtocrackingoftheweldedjointunderthelowertensilestress.Thesenewfindingswillhelptoimprovethepropertiesofnickel-irontypecastironelectrodesandthestrengthoftheweldedjoint.

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简介：Previousstudieshaveshownthatbaicalinpreventedironaccumulationaftersubstantianigrainjury,reduceddivalentmetaltransporter1expression,andincreasedferroportin1expressioninthesubstantianigraofrotenone-inducedParkinson’sdiseaserats.Inthecurrentstudy,weinvestigatedtherelationshipbetweenironaccumulationandtransferrinexpressioninC6cells,toexplorethemechanismsoftheinhibitoryeffectofbaicalinonironaccumulationobservedinParkinson’sdiseaserats.Ironcontentwasdetectedusinginductivelycoupledplasma-atomicemissionspectroscopy.Resultsshowedthatironcontentdecreased41%afterblockingdivalentmetaltransporter1andferroportin1proteins.Aftertreatmentwithferricammoniumcitrateofdifferingconcentrations(10,50,100,400μg/mL)inC6gliomacells,cellsurvivalrateandferroportin1expressionwerenegativelycorrelatedwithferricammoniumcitrateconcentration,butdivalentmetaltransporter1expressionpositivelycorrelatedwithferricammoniumcitrateconcentration.Baicalinordeferoxaminereduceddivalentmetaltransporter1expression,butincreasedferroportin1expressioninthe100μg/mLferricammoniumcitrate-loadedC6cells.Theseresultsindicatethatbaicalindown-regulatedironconcentration,whichpositivelyregulateddivalentmetaltransporter1expressionandnegativelyregulatedferroportin1expression,anddecreasedironaccumulationinthesubstantianigra.

简介：瞄准：为了阐明，在在各种各样的铁地位下面的含铁锡，转铁蛋白和转铁蛋白受体之中的铁的顺序的转移调节。方法：进粘膜、钠的蛋白质的59Fe的加入在控制WKY老鼠被执行。在含铁锡，转铁蛋白和转铁蛋白受体之中的铁的顺序的转移在铁被执行缺乏，控制和铁过载了老鼠。十二指肠的蛋白质被microautoradiography和免疫组织化学被特定的ELISA和原位本地化在双人脚踏车受到免疫降水和quantitation十二指肠的节。人的十二指肠的活体检视(n=36)从有不同的铁的题目镇定地位也为这些蛋白质被染色。结果：铁蛋白作为主要蛋白质被识别在十二指肠的粘膜以一种时间依赖者方式合并了铁。粘膜含铁锡的集中在与控制相比的铁过量组是显著地更高的，熨缺乏的组(731.5+/-191.96对308.3+/-123.36，731.5+/-191.96对256.0+/-1.19，P<0.005)，当比粘膜显著地高的钠转铁蛋白的没在这些组之中不同时(10.9+/-7.6对0.87+/-0.79，11.1+/-10.3对0.80+/-1.20，6.8+/-4.7对0.61+/-0.63，P<0.001)。蛋白质和熨斗分级的原位，和他们的重迭，建议了铁的顺序的转移的出现。这被表明然后通过铁的起始的绑定发生到钠转铁蛋白到吸收性的房间表面转铁蛋白受体。这些蛋白质的染色的紧张在人根据铁营养变化了，与在铁观察的转铁蛋白受体的强烈染色缺乏的题目。结论：肠通过包含钠转铁蛋白，transferrin-transferrin受体和含铁锡的相互作用的顺序的转移收起铁，这被结束。

简介：铁存款(BIF)的变形沉积类型是在世界，和这的簇打的超级大的铁矿石上的铁存款的最重要的类型在巴西包括QuadrilateroFerrifero区域和Carajas，在澳大利亚的Hamersley，在俄国的Kursk，在中国的印度和Anshan-Benxi的中央省。铁存款的Subordinated类型是magmatic，暴烈主人、沉积的。这份报纸简短在世界上介绍主要的超级大的铁矿石簇的地质的特征。在中国的铁矿石的证明储备是相对丰富的，但是他们主要是低档矿石。而且，铁矿石的体谅的部分是困难的为他们的困难的矿石调味品，深埋葬或另外的原因利用。铁矿石存款相对在11个metallogenic省(带)被集中，例如Anshan-Benxi，东方Hebei，Xichang中央的云南省和长江的中间降低的活动范围。主要minerogenetic时代广泛地变化从对太古代第四级，并且主要是对中间晚太古代原生地，Variscan，和Yanshanian时期。主要在中国的铁存款的7种基因类型被变形沉积类型(BIF)，magmatic类型，暴烈主人的类型，skarn类型，热水的类型，沉积类型和捱过的沥滤的类型。充满铁的矿石在skarn和海洋的暴烈主人的铁存款主要发生，局部地在变形沉积类型(BIF)同样热水的改革产品。矿藏和minerogenic模型的minerogenetic系列的理论在调查适用并且铁矿石沉积物勘探。空中地磁学的异例和地磁气的异例的深分析的联合，与严肃，异例是到寻求大、深埋葬的铁沉积物的一个有效方法。中国有铁矿石的一个相对大的寻找矿石的潜力，为特别变形沉积，skarn，和海洋的暴烈主人的铁沉积物。为铁和钢工业的更低的保证度，中国应该给一项做贸易并且打开外国采矿市场。

简介：AbstractObjective:Rubicon is an inhibitory interacting protein of the autophagy-related protein Uvrag. We previously showed that Rubicon deficiency promotes autophagic flux in vivo and that autophagy can degrade lipid droplets. This study aimed to investigate the effects of Rubicon deficiency on fasting-induced hepatic steatosis.Methods:Two-month-old wild-type (WT) and Rubicon-deficient mice were subjected to feeding or fasting for 24 hours to induce hepatic steatosis. The distribution of liver lipid droplets was revealed by oil red O staining. Hepatic and plasma triglyceride, non-esterified fatty acid (NEFA), and cholesterol levels were detected using commercially available kits. Real-time reverse transcriptasepolymerase chain reaction was performed to analyze the mRNA expression of genes related to lipid metabolism in the liver. Western blot was conducted to assess autophagy-related protein levels in the liver. The animal experiments were approved by the Institutional Animal Care and Use Committee at Shanghai Jiao Tong University, China.Results:We showed that under fasting conditions, Rubicon-deficient mice had more lipid droplets in the liver than WT controls. Consistent with these results, the hepatic triglyceride, NEFA, and cholesterol levels in fasted Rubicon-deficient mice were significantly higher than those of fasted WT controls. The levels of SREBP-1, a key regulator of lipid synthesis, were significantly lower in livers from fasted WT mice than those of fed WT mice. However, the decrease in SREBP-1 in fasted mice was attenuated by Rubicon deficiency. Western blot analysis demonstrated that the fasting-induced increase in autophagic flux was amplified by Rubicon deficiency. Finally, we showed that Rubicon deficiency in mice led to elevated plasma triglyceride and NEFA acid levels under fasting conditions.Conclusion:Rubicon deficiency exacerbates fasting-induced hepatic steatosis in mice.

简介：AIM:Tocomparethecornealparametersofchildrenwithcongenitalisolatedgrowthhormonedeficiencyandhealthysubjects.METHODS:Inthiscross-sectional,prospectivestudy,50caseswithgrowthhormone(GH)deficiencytreatedwithrecombinantGHand71healthychildrenunderwentacompleteophthalmicexamination.Thecornealhysteresis(CH),cornealresistancefactor(CRF),Goldmann-correlatedintraocularpressure(IOPg)andcorneal-compensatedintraocularpressure(IOPcc)weremeasuredwiththeOcularResponseAnalyzer(ORA).Centralcornealthickness(CCT)wasmeasuredbyaultrasonicpachymeter.RESULTS:Themeanagewas13.0±3.0yearsintheGHdeficiencygroupconsistingof21femalesand29malesand13.4±2.4yearsinthehealthychildrengroupconsistingof41femalesand30males.Therewasnostatisticallysignificantdifferencebetweenthegroupsforgenderorage(Chi-squaretest,P=0.09;independentttest,P=0.28,respectively).ThemeandurationofrecombinantGHtherapywas3.8±2.4yinthestudygroup.ThemeanCH,CRF,IOPgandIOPccvalueswere11.0±2.0,10.9±1.9,15.1±3.3,and15.1±3.2mmHgrespectivelyinthestudygroup.Thesamevalueswere10.7±1.7,10.5±1.7,15.2±3.3,and15.3±3.4mmHgrespectivelyinthecontrolgroup.ThemeanCCTvalueswere555.7±40.6,545.1±32.5μminthestudyandcontrolgroupsrespectively.TherewasnostatisticallysignificantdifferencebetweenthetwogroupsforCH,CRF,IOPg,IOPccmeasurementsorCCTvalues(independentt-test,P=0.315,0.286,0.145,0.747,0.13respectively).CONCLUSION:OurstudysuggeststhatGHdeficiencydoesnothaveaneffectonthecornealparametersandCCTvalues.ThisobservationcouldbebecauseofthedurationbetweenthebeginningofdiseaseandthediagnosisandbeginningofGHtherapy.

简介：磁铁矿(Fe3O4)nanotubes被减少综合赤铁矿准备(在5%H2+95%Ar空气的-Fe2O3)nanotubes，然后磁赤铁矿(-Fe2O3)nanotubes被重新氧化获得Fe3O4nanotubes。nanotube结构被不崩溃或在整个减少的高温度和重新氧化的过程的sintering。Fe3O4和-Fe2O3nanotubes的coercivities综合了与一样的阶段并且类似的尺寸比另外的nanostructures高两个都被发现分别地，是340.22Oe和342.23Oe。吸附的磷酸盐和nanotube结构为这高coercivity被认为负责。

简介：SixthinsectionsofspheroidalgraphitesincastironhavebeeninvestigatedbyTEMandSEM.ThespheroidalgraphitesconsistoftwoorthreelayersandhavenucleiwhicharecomposedofCe2O2SandCe2O3.Ceriumisexistedontonlyinnuclei,butalsoincentrallayerandmiddlelayerofgraphite.

简介：ThispaperreviewsthepresentdevelopmentsituationofrefractoriesforironmakingsysteminChina,whichincludesblastfurnace,hotblaststoveandcokedryquenching,etc.VarietiesandperformancesofrefractoriesusedbythetopsteelandirongroupssuchasBaosteel,WuhanI&SGroupandAnshanI&SGroupforironmakingwereexemplifiedandconcernedproblemswereanalyzed,togetherwithsolutionsandsuggestionsforfuturerefractoriesR&Dwork.

简介：WashDryIron能把脏衣服洗净并熨烫整齐。还能将衣服整齐挂好。而且非常节能。它具有一个巨大的清洁剂容器。用不着总往里面加洗衣粉。