简介:Thispapermainlysummarizestherecentprogressesforthecavitationstudyinthehydraulicmachineryincludingturbopumps,hydroturbines,etc..Especially,thenewlydevelopednumericalmethodsforsimulatingcavitatingturbulentflowsandtheachievementswithregardtothecomplicatedflowfeaturesrevealedbyusingadvancedopticaltechniquesaswellascavitationsimulationareintroducedsoastomakeabetterunderstandingofthecavitatingflowmechanismforhydraulicmachinery.Sincecavitationinstabilitiesarealsovitalissueandratherharmfulfortheoperationsafetyofhydromachines,wepresentthe1-Danalysismethod,whichisidentifiedtobeveryusefulforengineeringapplicationsregardingthecavitatingflowsininducers,turbinedrafttubes,etc.Thoughbothcavitationandhydraulicmachineryareextensivelydiscussedinliteratures,oneshouldbeawarethatafewproblemsstillremainsandareopenforsolution,suchasthecomprehensiveunderstandingofcavitatingturbulentflowsespeciallyinsidehydroturbines,theunneglectablediscrepanciesbetweenthenumericalandexperimentaldata,etc..Tofurtherpromotethestudyofcavitationinhydraulicmachinery,someadvancedtopicssuchasaDensity-Basedsolversuitableforhighlycompressiblecavitatingturbulentflows,avirtualcavitationtunnel,etc.areaddressedforthefutureworks.
简介:LocatedonthecoastoftheYellowSea,theQingdaoQianshaoPresisionMachineryCorporationisakeyenterpriseinChinaAeronauticIndustrialGeneralCorporationandisanationalexporterofmachineryandelectricalproducts.Thecorporationhasabout10subsidiariesandresearchinstitutes.Overthepastdecade,ithassetuptheKelinTechnologicalDevelopmentCorporation,theQingdaoYongqianElectronicsMeasuringEquipmentCo.Ltd,aSino-
简介:SINCEthemachineryindustrybecomealltherageinChina,DoublestarMachineryCo.,Ltd.hasprovedtobeoneofthemainstaysoftheDoublestarGroup,whichmainlyturnsoutshoesandtires.DoublestarMachineryisacomprehensivemachineryenterpriseincorporatingscientificresearch,design,manufacturing,installationandconsulting.
简介:Presentsituationandfutureofweldingmachineryindustry¥LIJianguoandZHUQi(ChengduElectricWeldingMachineResearchInstitute(610051))...
简介:SituatedinthesouthernsuburbsofGuilinCityandfoundedin1966,theGuilinRubberMachineryFactoryisaspecialfactoryundertheMinistryoftheChemicalIndustryproducingrubbermachinery.Thefactoryhasastaffof1,900.fixedassetsofRMB110million,advancedequipment,astrongtechnicalforceandcompleteproductcategories.Itsmainproducts—double-moldtyresettingvulcanizers—accountfor40
简介:AbstractObjectives:Mechanistic target of rapamycin (mTOR) activation has been identified in keloid. This study aimed to identify the role of mTOR-dependent autophagy activity in keloid.Methods:We detected the expression of specific proteins representing mTOR activity and baseline autophagy levels in keloid tissues (KTs) and primary keloid fibroblasts (KFs) using immunohistochemical staining and western blotting. Simultaneously, the formation of acid vesicles was assessed by acridine orange staining in KFs. To investigate whether mTOR-dependent pathway mediated the regulation of autophagy machinery in keloid, we first validated whether mTOR inhibitors, rapamycin (100 nmol/L) and KU-0063794 (5 μmol/L), could inhibit mTOR activity in KFs by western blotting. Then we explored the reverse effects on autophagy activity induced by mTOR inhibitors in the presence of lysosomal protease inhibitors by western blotting.Results:It demonstrated elevated expression of mTOR, S6, and their activated forms in KTs, and an elevated expression of p-S6 Ser235/236 in KFs, suggesting mTOR was activated in keloid. Less LC3 and Beclin1 were expressed in the cytoplasm of KFs, whereas Ubiquitin was abundantly expressed in KTs compared with extra-lesional tissues. In addition, at the cellular level, an impeded conversion of LC3-I to LC3-II was shown in KFs and the formation of acid vesicles were also decreased in KFs compared with normal fibroblasts (NFs), indicating that autophagy activity is defective in keloid. mTOR inhibitors, Rapamycin (E-64d + pepstatin vs. rapamycin + E-64d + pepstatin: [0.88 ± 0.35] vs. [1.56 ± 0.46], F= 5.56, P= 0.049) and KU-0063794 (E-64d + pepstatin vs. KU-0063794 + E-64d + pepstatin: [0.92 ± 0.22] vs. [1.51 ± 0.25], F= 25.88, P= 0.011) can reverse the inhibition effect on autophagy of KFs while inhibiting mTOR activity.Conclusion:Autophagy machinery is inhibited in keloid which is regulated by mTOR-dependent pathway.
简介:Thispaperpresentsananalysisofthepotentialforenginespeedreductioninhydraulicequipment,takingintoaccountnotonlytheminimumenginespeedrequiredtomeetthecurrentflowdemand,butalsotheminimumspeedcapableofacceleratingtheenginetomeetincreasedflowdemandinthenearfuture.Thisisapredictivetask,asitrequiresanestimateoftheoperator'sintentiontoincreaseflowdemand.Wepresentananalysisofthepotentialforenginespeedreductionusingaworkcyclefroma40tonexcavatorloadingatruck,whichresultsinapotential33%reductioninthemeanenginespeedwithnoreductioninusefulworkrate.Wealsopresenttwonewenginespeedcontrolalgorithmstoperformthispredictivetask.
简介:Inahybridsystem,thesubsystemswithdiscretedynamicsplayacentralroleinahybridsystem.Inthecourseofengineeringmachineryofclusterconstruction,thediscretecontrollawishardtoobtainbecausetheconstructionenvironmentiscomplexandthereexistmanyaffectingfactors.Inthispaper,hierarchicallyintelligentcontrol,expertcontrolandfuzzycontrolareintroducedintothediscretesubsystemsofengineeringmachineryofclusterhybridsystem,soastorebuildthehybridsystemandmakethediscretecontrollaweasilyandeffectivelyobtained.Thestructures,reasoningmechanismandarithmeticofintelligentcontrolarereplantedtodiscretedynamic,conti-nuousprocessandtheinterfaceofthehybridsystem.Thestructuresofthreetypesofintelligenthybridsystemarepresentedandthehumanexperiencessummarizedfromengineeringmachineryofclusteraretakenintoaccount.
简介:Thestate-ownedQunfengMachineryWorksisaspecializedfactoryundertheMinistryofAviationandSpaceIndustrymanufacturinglinemantools.Takingfulladvantagesofthesuperiorityoftechnicalforcesandfacilitiesexistedinthisindustry,overonehunderdkindsoflinemantoolsincludinghot-linetoolsmadeofhighstrengthaluminumalloyforhighvoltagetransmissionlinesupto500kVhavebeenmanufacturedsince1979.Someofthefoolswillbeintroducedinsuccessiveisuesinthis
简介:当为林地生产提起机械化层次时,林地机械的合适的匹配是重要的。在匹配的过程,林地机械不必仅仅为解决问题的专家知识,而且改进方法。我由在一个分析、层次的过程计算各种各样的林地机器的量的参数的类似建议基于盒子的推理的联合(CBR)(RBR)并且基于规则的推理。我计算了在森林工业过去常启用更好的选择的机械的类似并且设备匹配。我建议基于单个参数重量在申请的进程在被修改的偏差的广场的和调整方法的重量值。在系统设计的过程期间,我提出了一个设计方法知识库并且产生了推理的一张动态网集成森林工业的过程的框架机械选择和重量值调整。这启用推理效率的完全的系统和改进的范围的扩大。我用一个实际例子表明这个方法的有效性和有实行可能。
简介:纸为帮助产品设计和机械系统的开发论述扩充现实的应用程序。扩充现实技术以如此的一个方法用一个交互真实的词集成一个交互产生计算机的词,他们作为一环境出现。AR技术能与不实际上是景色的部分,但是与在场的用户相关的信息提高真实世界的一种用户感觉活动。在AR系统介绍了3D建模的为特别改变数据的看法的一个模式正在允许用户以一个更全面的方法理解未来的机械系统,因此使设计进程比那更有效由常规今日的CAD系统支持了。介绍原型系统包含与AR系统综合的一个专家系统并且允许关于一个活动机器人的设计过程和认识到的构造上的问题的实际答案的连续的步送到知识设计者。有关AR的一条途径使系统用户能分析并且验证解决方案(作为3D代表了模型)相对真实景色/目标。因为在我们附近的真实环境经常提供是困难的在一台计算机复制的信息的广阔数量,这条途径是有益的。在一些情况中,一个AR系统的应用程序能是验证发达产品的一个最佳的方法。
简介:TheConstructionMachineryDivision(CMD)intheRe-searchInstituteofElectricPowerConstruction(EPCRI)isaR&Dorganizationspecializedonconstructionmachineryandtechnologyforthermalpowerstationandtransmission&distributionprojects.Itwasestablishedin1964.Therearenow45scientificre-
简介:Inordertosolvethehigh-priceandshort-lifetimeproblemsofthecutterofagriculturalmachinery,andimprovethewearresistanceofthecutter,theTiCN/FemetalceramiccompositecoatingwaspreparedonthesubstrateofQ235steelbyreactionnitrogenarccladdingtechnique.ThemixturepowderoftitaniumandgraphitewaspreplacedontheQ235steelsurfaceafterintensivemixingbyplanetaryballmillandgluingwithstarchbinder.Themicrostructureandphaseofthecoatings,interfacebehaviorbetweencoatingsandthesubstratewereinvestigatedbyscanningelectronicmicroscopeandX-raydiffractometer.Themicro-hardnessdistributionofthecoatingsectionwastestedbymicro-hardnesstester.Frictioncoefficientandwearweightlossweremeasuredbyabrasionmachine.Wearingsurfacemorphologywasinvestigatedbyscanningelectronicmicroscope.TheresultsshowthatanexcellentbondingbetweenthecoatingsandtheQ235steelsubstrateisensuredbythestrongmetallurgicalinterfaceandphaseofthecoatings.ThecoatingsaremainlycomposedofTiCN.Thehighestmicrohardnessofthecoatingsreaches1089HVO.2,whilethemicro-hardnessofQ235steelsubstrateisonlyabout286HVO.2.Theanti-abrasivetestresultsshowthatthewearresistanceofthecladdingcoatingisbetterthanthatofquenchedandtempered65Mnsteelwhichisoftenusedascutterofagriculturalmachinery.ThefieldtestresultsshowthattheTiCN/Femetalceramiccompositecoatingpreparedbyreactionnitrogenarccladdingisfeasibletothemanufactureandremanufactureofthecutterofagriculturalmachinery.
简介:新鲜的水息肉水螅属于门Cnidaria,它在bilaterians的外观前从后生动物的系分叉。以便在metazoans理解apoptosis的进化,我们开始阐明了在这个模型有机体的分子的细胞死亡机械。基于EST和整个水螅染色体集会,我们识别了15caspases。我们证明一个人在apoptosis期间被激活,四与N终端DED,卡片或DD领域有开始者caspases的特征,二在vitro经历autoprocessing。另外,我们描述七Bcl-2-like和二象Bak一样蛋白质。为大多数Bcl-2家庭蛋白质,我们观察了mitochondrial本地化。当在哺乳动物的房间表示了时,象HyBak一样1和2强烈导致的apoptosis。禁止的apoptosis与显示出特别强壮的保护的效果的HyBcl-2-like4在哺乳动物的房间由camptothecin劝诱了的六个Bcl-2家庭成员。这蛋白质也与象HyBak一样交往了1在酵母二混血儿的试金。在它的BH3领域的保存白氨酸的变化两个都与象HyBak一样废除了相互作用1并且anti-apoptotic效果。而且,我们BH-3-only描述新奇水螅蛋白质。这些之一与Bcl-2-like4交往了并且在哺乳动物的房间导致了apoptosis。我们的数据显示为房间死亡规定的一个复杂网络的进化在多细胞的组织的最早、最简单的水平产生了,它在此展出了一复杂性实质地高级比在protostome模型有机体Caenorhabditis和果蝇。