简介：AbstractOmicron (B.1.1.529), the fifth variant of concern (VOC) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was firstly identified in November 2021 in South Africa. Omicron contains far more genome mutations than any other VOCs ever found, raising significant concerns about its increased transmissibility and immune evasion. Here, we report the importation of the Omicron variant into Beijing, China, in December 2021. Full-length genome sequences of five imported strains were obtained, with their genetic features characterized. Each strain contained 57 to 61 nucleotide substitutions, 39 deletions, and 9 insertions in the genome. Thirty to thirty-two amino acid changes were found in the spike proteins of the five strains. The phylogenetic tree constructed by the maximum likelihood method showed that all five imported genomes belonged to Omicron (BA.1) (alias of B.1.1.529.1), which is leading to the current surge of coronavirus disease 2019 (COVID-19) cases worldwide. The globally increased COVID-19 cases driven by the Omicron variant pose a significant challenge to disease prevention and control in China. Continuous viral genetic surveillance and increased testing among international travellers are required to contain this highly contagious variant.

简介：AbstractCOVID-19 has been a global health concern since 2019 until date. Global concerted efforts to combat this pandemic has resulted in a number of vaccines distributed across the globe. Although the presence of these vaccines produced quick interventions, dynamic mutation in the causal virus and the continuous evolution of new stains that defy available vaccines has given rise to pertinent questions. The most recent emergence of a new COVID-19 virus variant (omicron), the rapid spread and overwhelming rate of morbidity and mortality has reopened these questions for debate. This commentary summarizes major view on these questions and concludes that multiple approach including social behavioural measures, vaccination and antiviral drug would speed up elimination process.

简介：AbstractThe recently emerged Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has quickly spread around the world. Although many consensus mutations of the Omicron variant have been recognized, little is known about its genetic variation during its transmission in the population. Here, we comprehensively analyzed the genetic differentiation and diversity of the Omicron variant during its early outbreak. We found that Omicron achieved more structural variations, especially deletions, on the SARS-CoV-2 genome than the other four variants of concern (Alpha, Beta, Gamma, and Delta) in the same timescale. In addition, the Omicron variant acquired, except for 50 consensus mutations, seven great new non-synonymous nucleotide substitutions during its spread. Three of them are on the S protein, including S_A701V, S_L1081V, and S_R346K, which belong to the receptor-binding domain (RBD). The Omicron BA.1 branch could be divided into five divergent groups spreading across different countries and regions based on these seven novel mutations. Furthermore, we found that the Omicron variant possesses more mutations related to a faster transmission rate than the other SARS-CoV-2 variants by assessing the relationship between the genetic diversity and transmission rate. The findings indicated that more attention should be paid to the significant genetic differentiation and diversity of the Omicron variant for better disease prevention and control.

简介：AbstractSince its first discovery, the Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evoked another wave of infection and caused global concern and panic. Moreover, although the data are still limited, Omicron showed highly concerning characteristics, including higher transmissibility, extensive immune escape and potentially altered host range. We interpreted these characteristics based on currently available data and outlined some urgent questions, calling for a more comprehensive investigation.

简介：Anadaptivealgorithmforsolvinglargenonsymmetriclinearsystemsispresentedinthispaper.ThenewalgorithmcombinespolynomialpreconditioningtechniquewiththeCGNRmethod.Residualpolynomialisusedinthepreconditioningtoestimatetheeigenvaluesofthes.p.d.matrixArA,andtheresidualpolynomialisgeneratedfromseveralstepsofCGNRbyrecurrence.Thealgorithmisadaptiveduringitsimplementation.Therobustnessismaintained,andtheiterationconvergenceisspeededup.Twonumericaltestresultsarealsoreported.

简介：Inthepresentpaper,wedealwithChlodowskytypegeneralizationoftheBaskakovoperators,specialcaseoftheseoperatorsincludesChlodowskytypeMeyer–KonigandZelleroperators(see[21]).WiththehelpofBohman-Korovkintheorem,weobtainsomeapproximationpropertiesfortheseoperators.Wegiveamodificationoftheoperatorsinthespaceofdifferentiablefunctionsandwealsopresentexamplesofgraphsforapproximation.Finally,weapplytheseoperatorstothesolutionofthedifferentialequation.

简介：InthispaperthegeneralizedBianchi’sidentitiesforthevariantconstrainedsystem(GBIVOS)withnon-invariantactionintegralandconstraintconditionswasderived,andthestrongandweakconservationlawsforsuchsystemwasdeduced.ThepreliminaryapplicationsoftheGBIVCStothecaseforsomemodelsoffieldtheorieswasgiven.TheDiracconstraintofsuchsystemwasdiscussed.

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简介：Inthepresentpaper,weintroduceSzász-Durrmeyer-BézieroperatorsMn,o(f,x),whichgeneralizethetionsofboundedvariation.OurresultextendsandimprovesthatofSahaiandPrasad[9]andGuptaandPant[3].

简介：PlantWRKYtranscriptionfactors(TFs)constituteoneofthelargestfamiliesofproteinsinvolvedinbioticandabioticstressresponses.TheseTFshaveaconserved60aminoacidWRKYdomainattheN-terminalandazincfingermotifattheC-terminal.ToexaminetherelevanceofOsWRKY72inimpartingsalinitystresstolerance,twoindicaricegenotypes,Rasi(tolerantgenotype)andTellahamsa(susceptiblegenotype),wereused.InRasiseedlingsat12hunder100mmol/LNaClstress,OsWRKY72expressionwasup-regulated,whereasinTellahamsa,itwashighlyup-regulatedatlethalstress.Full-lengthOsWRKY72cDNAwasclonedfromthesetworicegenotypesforfurtheranalysis.Weidentifiedavariant,termedasOsWRKY72bthatcarriesanadditionalsequenceof111bpwithintheWRKYdomain.ExpressionofOsWRKY72bwashigherundersalinitystressinRasithaninTellahamsa.DisorderpredictionofOsWRKY72bshowedthattheadditionalsequenceintheWRKYdomainisorderedtherebymaintainingthetertiarystructurethatmightinteractwiththemajorgrooveofDNA.PredictionofphosphorylationsitesinOsWRKY72bindicatedthatafewserineresiduescouldbethepotentialphosphorylationsites.Inthisstudy,wefirstlyreportedaOsWRKY72variantthatcouldhavearoleinabioticstressresponses.

简介：【摘 要】 总结广西壮族自治区防城港东兴市公共卫生急救中心的35例Omicron无症状感染者隔离期间的护理要点，主要是根据无症状感染者入住隔离区后的病情及心理特点采取有效的护理措施。经过个性化的护理，全部患者配合治疗和护理并康复出院，无后遗症发生。

简介：Itisaveryimportantandcomplicatedissuetochooseandconfirmtechnologyschemes,whichisalsoacomplicatedsystemengineeringthathascharacteristicssuchasmulti-factor,multi-levelandmulti-goaletc.Soweneedtooptimizeandappraiseitwiththemethodofmulti-goalandmulti-principle.Basedondiscussingtherelationbetweentechnologyandeconomy,thispaperputsforwardthefactorswhichshouldbeconsideredtoappraisetechnologyschemessynthetically,thoughtsandmethodsofvariantvalue-weighted,andbringsforwardanewsyntheticalappraisalmodelwhichcanappraisetechnologyschemesobjectivelyandcomprehensively.

简介：BymeansofthefrozentimeapproachandtheKroneckerproduct,twocriteriaofasymptoticstabilityarederivedforthelinear,timevariantdynamicsystemswitheithershorttimedelaysorwithweakfeedbackinvolvingarbitrarytimedelays,respectively.Itisfoundthattheasymptoticstabilityoftheseretardeddy-nainicsystemsisgovernedbythemaximalandminimalsingularvaluesofthecoeffi-cientmatricesandtheirtimederivatives.

简介：Inthispaperanewmethodtorealizerationalgeneralizedtransferfunctionsoflinearshift-variantdigitalfiltersthroughstatefeedbackispresentedInsomepracticalapplicationstherequiredcharacteristicsofthefilterchangeslowly.Underthesecircumstances,theproposedmethodisveryeffectiveandtheresultingfilterstructureissimple.Anumericalexampleisprovidedtoshowtheperformanceofthemethod.

简介：这份报纸由在矩阵的半张肌产品的框架下面使用图论的方法在一个温和假设下面处于状态与时间变体延期为布尔控制网络(BCN)的observability给一个相等的条件。首先，在考虑下面的BCN被分成没有时间延期的分系统的一个有限数字。第二，BCN的observability被测试所谓的observability的observability验证构造路径(没有时间延期的一个特殊分系统)基于图理论。这些结果在BCN的observability上扩大最近的相关结果。例子被显示说明结果的有效性。

简介：摘要新型冠状病毒Omicron（B.1.1.529）变异株具有传播力强、传播速度快、免疫逃逸显著等特点，给新型冠状病毒肺炎疫情防控带来新的挑战。该变异株于2021年11月在南非被发现后，历时2个月便成为全球主要流行株，我国已有多个省份报告Omicron变异株引发的本土疫情。然而，Omicron变异株的高度突变对其流行病学特征的影响仍不够明晰。本文基于现有研究证据，针对Omicron变异株与功能有关的突变、传播力、毒力、免疫逃逸能力及免疫交叉反应等重要方面进行综述，为新型冠状病毒肺炎疫情的科学防控提供参考。

简介：AbstractIntroduction:Congenital ichthyosiform erythroderma (CIE) is characterized by fine, whitish scales on a background of erythematous skin over the whole body; it is reportedly caused by mutations in ABCA12, ALOX12B, ALOXE3, CERS3, CYP4F22, NIPAL4, PNPLA1, and TGM1 genes.Case presentation:A 15-month-old girl presented with CIE associated with compound heterozygous ABCA12 mutations, a known missense mutation c.4139A>G (p.Asn1380Ser) from her father, and a novel missense mutation c.4300A>G (p.Thr1434Ala) from her mother.Conclusion:This is the first report to indicate that compound heterozygous missense mutations in the first ATP-binding cassette of ABCA12 could contribute to the onset of CIE.

简介：Watershedsegmentationissuitableforproducingclosedregioncontourandprovidinganaccuratelocalizationofobjectboundary.However,itisusuallypronetoover-segmentationduetothenoiseandirregulardetailswithintheimage.Forthepurposeofreducingover-segmentationwhilepreservingthelocationofobjectcontours,thewatershedsegmentationbasedonmorphologicalgradientreliefmodificationusingvariantstructuringelement(SE)isproposed.Firstly,morphologicalgradientreliefisdecomposedintomulti-levelaccordingtothegradientvalues.Secondly,morphologicalclosingactionusingvariantSEisemployedtoeachlevelimage,wherethelowgradientlevelsetsusethelargeSE,whilethehighgradientlevelsetsusethesmallone.Finally,themodifiedgradientimageisrecomposedbythesuperpositionoftheclosedlevelsets,andwatershedtransformtothemodifiedgradientimageisdonetoimplementthefinalsegmentation.Experimentalresultsshowthatthismethodcaneffectivelyreducetheover-segmentationandpreservethelocationoftheobjectcontours.

简介：WepresentanF-expansionmethodforfindingperiodicwavesolutionsofnonlinearevolutionequationsinmathematicalphysics,whichcanbethoughtofasaconcentrationofextendedJacobiellipticfunctionexpansionmethodproposedrecently.ByusingtheF-expansion,withoutcalculatingJacobiellipticfunctions,weobtainsimultaneouslymanyperiodicwavesolutionsexpressedbyvariousJacobiellipticfunctionsforthevariantBoussinesqequations.Whenthemodulusmapproaches1and0,thehyperbolicfunctionsolutions(includingthesolitarywavesolutions)andtrigonometricsolutionsarealsogivenrespectively.

简介：Theredistributionoftheenergyflowoftightlyfocusedellipticity-variantvectoropticalfieldsispresented.Wetheoreticallydesignandexperimentallygeneratethiskindofellipticity-variantvectoropticalfield,andfurtherexploretheredistributionoftheenergyflowinthefocalplanebydesigningdifferentphasemasksincludingfanlikephasemasksandvortexphasemasksonthem.Theflexiblycontrolledtransverseenergyflowringsofthetightlyfocusedellipticity-variantvectoropticalfieldswithandwithoutphasemaskscanbeusedtotransportmultipleabsorptiveparticlesalongcertainpaths,whichmaybewidelyappliedinopticaltrappingandmanipulation.