简介：AbstractObjective:This study aims to describe presenting characteristics of patients diagnosed with non-invasive chronic rhinosinusitis (CRS) following liver or kidney transplant and determine factors associated with disease-related complications, selection of endoscopic sinus surgery (ESS), and disease resolution in this population.Study design:Retrospective chart review.Setting:An academic tertiary care center (Mayo Clinic, Rochester, Minnesota).Subjects and methods:Liver and kidney transplant recipients evaluated by Mayo Clinic otolaryngologists for CRS between 1998 and 2018 were identified. Univariate and multivariate logistic regression analyses were used to determine patient factors and treatment modalities associated with developing complications, selection of ESS, and disease resolution.Results:Fifty-seven patients met inclusion criteria. No patients developed intraorbital or intracranial complications of their CRS. Multivariate modeling demonstrated that the presence of polyps (P = 0.036) was associated with undergoing ESS within one year of presentation. A higher Lund-Mackay (LM) computed tomography score (P = 0.023) and older age (P = 0.018) were significantly associated with decreased disease resolution. No other factors were significantly associated with the use of endoscopic sinus surgery within one year of otolaryngology presentation or resolution of CRS in this cohort.Conclusion:The risk of developing CRS-related intraorbital or intracranial complications in this immunecompromised patient cohort may be lower than originally thought. For liver- and kidney-recipients stable on immunosuppressive medication for many years, prognostic factors for CRS may mirror those for immunocompetent patients.

简介：AbstractPatients with aspirin exacerbated respiratory disease (AERD) experience a severe and recalcitrant form of chronic rhinosinusitis with nasal polyposis (CRSwNP) and asthma, which are exacerbated by aspirin/NSAID ingestion. As compared with aspirin-tolerant CRSwNP, patients with AERD experience more severe olfactory dysfunction, which is one of the key contributors to the observed decrease in quality of life (QOL) in this disease. The objective of this paper is to review the published olfactory outcomes observed with various treatment modalities.

简介：PurposeThisstudywasdonetoverifytheeffectivenessofacupuncturetreatmentonnasalobstructioncausedbyallergicrhinitisorrhinosinusitis,andtoknowtheclinicaleffectofanovelacupuncturepointnamedSim-eui.MethodRhinitispatientswithatleasttwovisitstothehospitalfromSeptember,2009toNovember,2009wererandomizedintoeitherexperimentorcontrolgroup.Theexperimentgroupweretreatedwithacupunctureongenerallyusedpointsofrhinitis,thatareGV22,GV23,GV24,ST8(bothsides),BL2(bothsides),ST4(bothsides),aswellasSim-euipoint.ThecontrolgroupweretreatedwiththegeneralpointsandLI20(bothsides)insteadofSim-euipoint.Acupunctureneedleswereleftinfor15minutesforbothgroups.TheinitialandfinalsymptomscoresofSNOT-20andamodifiedVASwereusedtoevaluatetheeffectiveness.TheprogramusedforstatisticalanalysiswasSPSS15.0forwindow.WilcoxonSignedRanksTestwasdonetoanalyzetheintra-groupsymptomscorechangebeforeandaftertreatment,andMann-WhitneyTestwasusedtocompareinter-groupVASchange.Allthestatisticswereverifiedatasignificancelevelof5%.ResultTheSNOT-20scoresbeforeandafteracupuncturetreatmentshowedsignificantchangesonbothexperimentandcontrolgroups,buttherewasnosignificantdifferencebetweenthetwogroups.AllcategoriesoftheSNOT-20showedsignificantresult,exceptthe'Wakeupatnight'and'Lackofagoodnight'ssleep'entries.ThemodifiedVASshowedsignificantimprovementofsymptomintheexperimentgroupcomparedwithcontrolgroup.ConclusionAcupuncturetreatmentusingSim-euipointseemstobehelpfulinimprovingqualityoflifebyimmediatereliefofnasalobstruction.