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简介：AbstractBackground:Endolymphatic sac tumor (ELST) is one of neuroectodermal tumor which arising from endolymphatic sac and duct. It is actually quite rare, with less than 200 cases reported. Although ELST presents benign appearance in histopathology, it can present aggressive destructive behavior in clinical. The cornerstone of treatment for ELST is complete surgical excision. However, it is almost impossible to completely resect the advanced stage tumor. There is still controversy about other treatments, such as radiotherapy and gamma knife surgery.Case presentation:A 47-year-old man was admitted in The First Affiliated Hospital of Fujian Medical University with a 7-year history of progressive hearing loss and near 6-month repeated attacks of headache. Preoperative CT revealed a massive intracranial lesion and associated hydrocephalus. MR scanning demonstrated a 7.2 cm × 4.6 cm × 4.2 cm bulky mass located in left-sided posterior cranial fossa and temporo-occipital region which showed hyperintensity on T1-weighted images and mixed signal intensity on T2-weighted images. There was no neither clinical manifestation nor family history of Von Hippel-Lindau syndrome (VHL).Due to the mass that was large and invading the bone of skull base, it was difficult to extirpate surgically, so the ventriculoperitoneal shunt combined with local biopsy was performed. The postoperative pathology and immunohistochemical findings confirmed the lesion was an endolymphatic sac tumor. After operation, the patient regularly received radiotherapy.Conclusion:The widely accepted management of ELST is complete surgical resection. However, it is difficult for surgeons to achieve radical resection with late-stage ELST. Currently, there is much dispute about the role of radiotherapy for the management of ELST in academic circles. In this case where the mass cannot be surgical removed, radiotherapy has the curative effect for ELST in terms of disease control and quality of life.

简介：ObjectiveTostudyclinicalcharacteristicsofendolymphaticsactumor(ELST)anditsdiagnosisandtreatment.MethodsELSTwasdiagnosedin6casesbasedonsurgicalandhistologicalfindings.Thesecaseswerereviewedfortheirclinicalmanifestations,differentialdiagnosisandsurgicaltreatmenttechniques.ResultsTherewere1maleand5femalesinthisgroup,agedfrom28to59years(meanage=38.7years).Thetumorwasinleftearin4casesandinrightearintheother2cases.Diseasecoursesrangedfrom5to30years(meanduration=12.6years).Clinicalpresentationsincludedsensorineuralhearingloss(n=4),otorrheaandtinnitus(n=2),tinnitusandfacialspasm(n=1),otorrheawithfacialparalysis(n=1),andhearinglosswithtinnitus(n=2).NoneofthecaseswasdiagnosedasELSTpreoperatively.Twocasesweremisdiagnosedasglomusjugularetumor,2aschronicsuppurativeotitismedia,1assweatglandadenomaonbiopsyand1astemporalbonetumor.Tumorsweresurgicallyresectedinall6casesviathemastoidectomy(n=2)orcombinedoto-cervicalorcranio-oto-cervicalapproaches(n=4).Postoperativecerebrospinalfluidotorrheaoccurredin1case.Thetumorswereconfirmedonhistologicalexaminationtobealow-gradeadenocarcinoma.Allpatientshavesurvivedatthetimeofthispaper.ConclusionELSTisrareandcommonlymisdiagnosedandinadequatelytreated.Itsprognosisisrelativelyfavorablebecauseofitsslowgrowthrate.

简介：市场中的个别信息掌握者利用手中的非公开信息谋取非法利益,以内幕信息买卖证券获利的行为被称为内幕交易。内幕交易会导致证券市场的效率降低、规模缩小,上市公司筹集不到需要的资金,带来非常严重的后果。本文综合研究了美国SAC资本公司的内幕交易案件的动机、过程和后果。最后,结合中美法律环境,提出我国在内幕交易治理方面可借鉴的经验做法。

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简介：BackgroundNormally,fewimmunocompetentcellarepresentintheendolymphaticsac(ES).Duringanactiveimmuneresponseintheinnerear,largeamountofinflammatorycells,includingimmunocompetentcells,areseenintheES.ThecurrentstudyaimedatassessingcellularproliferationwithintheESduringinducedimmuneresponseintheinnerear.MethodsFifteenhealthy,femaleSDratsweresensitizedsystemicallywithkeyholelimpethemocyanin(KLH),followedbylocalinoculationinthecochleathroughbasalturnfenestrationwiththesameantigen.OnDays3,7and14followinginoculation,theanimalwassacrificedafterintraperitonealadministrationof5-bromo-2'-deoxyuridine(BrdUrd),andthetemporalboneharvested.Followingdecalcification,infiltrationbyBrdUrd-andIgG-positivecellsintheESwasstudiedonfrozensectionswithH&Eandimmunohistochemicalstaining.ResultsDuringthesecondaryimmuneresponseintheinnerearagainstT-dependentantigens,thereisincreasedcellularproliferationintheES.Theproliferatedcellsmaydifferentiateintoimmunocompetentcellsatthesamelocation.ConclusionsThesefindingsindicatethattheESplaysanimportantroleinimmuneresponseofinnerear.

简介：摘 要：为了验证SAC结构用于薄层罩面具有优越性，本文对SAC-10和AC-10两种沥青混合料铺筑的薄层罩面路用性能进行对比分析，结果表明：将SAC-10骨架密实结构沥青混合料用于薄层罩面，抗车辙性能远高于悬浮密实结构的AC-10沥青混合料，具有较优的抗滑特性。

简介：12月11日，上汽自主品牌“赛宝”多功能车首次出口叙利亚等国。根据合同，将向叙利亚等国出口“赛宝”车1000辆。直到去年第一款车型-取自赛欧同一平台的“赛宝”多功能车型下线之时，沉默多时的上汽仪征才浮出水面。

简介：Extragonadalprimaryyolksactumoroftheintestinaltractoriginisexceedinglyrare.Throughamultipledisciplinaryteam,thediagnosisandtreatmentofprimaryintestinalyolksactumorwerefurtherdefined.Wereport2suchcaseswithdetailedhistologicandimmunohistochemicalanalysis.Thetwopatientswerea7-year-oldgirlanda29-year-oldwoman.Bothofthempreoperativelyhadanelevatedserumalphafetoprotein(AFP)level(≥1,210ng/mL).Thetumorsarelocatedintheintestineandimagingexaminationindicatedtherectumastheprimarysite.Grosslythemasswasgrey-whiteandcrisptexture.Microscopicexaminationfeaturedreticular,microcystic,macrocystic,papillary,solid,andsomeglandularpatterns.Immunohistochemically,tumorcellsofbothcaseswerepositiveforSALL4,AFP,pan-cytokeratin(AE1/AE3),andglypican-3.Simultaneously,astainforEMA,OCT4,CD30,HCG,vimentinandCK20werenegativeinall2neoplasms.Thefeaturesofmorphology,immunohistochemistry,laboratoryexaminationsandimagingstudiesconsistofthediagnosisofprimaryyolksactumoroftheintestine.

简介：成型良好对沥青路面的性能发挥和质量保证至关重要。本文简要分析了马歇尔击实和旋转压实两种方法原理上的区别,通过试验对比,研究两者对SAC沥青混合料体积参数的影响,指出旋转压实成型方法相较马歇尔击实方法,能更好地模拟路面实际成型过程,体积指标更优。

简介：随着我国高速公路的飞速发展,交通量不断增长、车速不断提高,同时重载车辆也不断增多,因此,沥青路面的抗滑性能及高温稳定性能已经成为沥青路面的焦点问题。沥青玛蹄脂碎石（SMA）以其优越的高温稳定性、抗滑性在我国得到广泛的推广应用,而多碎石沥青混凝土（SAC）是由我国自主研发的路面结构,并在京石高速、沪宁高速等项目中得到了很好的应用。

简介：囊包含域的蛋白质属于phosphoinositide磷酸酶(PIPPase家庭)的一个最新识别的家庭。尽管有描绘得好的酶的活动，这个哺乳动物的囊领域PIPPase家庭的生物功能仍然保持大部分未知。我们识别了新奇的囊包含域的蛋白质，老鼠Sac3(rSac3)它是广泛地在各种各样的纸巾表示了并且对endoplasmic蜂窝胃局部性，Golgi复杂、再循环的内涵体。rSac3在vitro作为底层与PI(3)P，PI(4)P和PI(3,5)P(2)显示PIPPase活动，并且在囊域的催化核心的一个变化废除它的酶的活动。rSac3的表示起来在刺激的神经生长因素(NGF)期间调整了PC12细胞neuronal区别，并且在这的表示上，蛋白质在PC12细胞支持神经突长出。相反地，由反感觉oligonucleotides的rSac3表示的抑制减少刺激NGF的PC12房间的神经突长出，并且rSac3的活跃地点变化消除它的neurite-outgrowth-promoting活动。这些结果显示rSac3在通过它的PIPPase活动区分神经原支持神经突长出，建议囊领域PIPPase蛋白质可以参予从到血浆膜的endoplasmic蜂窝胃和Golgi建筑群的前面的膜交通国王，并且可以作为neuronal房间生长和区别的这个关键过程的管理者工作。

简介：TheCu/Sn-3.OAg-0.5Cu/Cubuttingsolderjointswerefabricatedtoinvestigatetheevolutionoftheinterfacialintermetalliccompound(IMC)andthedegradationofthetensilestrengthofsolderjointsundertheeffectofelectromigration(EM)andagingprocesses.Scanningelectronmicroscopy(SEM)resultsindicatedthattheCu_6Sn_5interfacialIMCpresentedobviousasymmetricalgrowthwiththeincreaseofEMtimeundercurrentdensityof1.78×10~4A/cm~2at100℃,andthegrowthofanodicIMCpresentedaparabolicrelationshipwithtimewhilethecathodicIMCgotthinnergradually.However,asforagingsamplesat100℃withoutcurrentstressing,theCu_6Sn_5IMCpresentedasymmetricalgrowthwithaslowerratethantheanodicIMCofEMsamples.Thetensileresultsindicatedthatthetensilestrengthofthesolderjointsundercurrentstressdeclinedmoredrasticwithtimethantheagingsamples,andthefracturemodetransformedfromductilefracturetobrittlefracturequicklywhilethefracturemodeofagingsamplestransformedfromcup-coneshapedfracturetomicroporousgatheringfractureinaslowway.

简介：Theproject'commercialapplicationof10kt-scaleproductionoftheSAC-2000acrylonitrilesynthesiscatalyst'jointlyundertakenbytheSINOPECShanghaiPetrochemicalResearchInstitute(SPRI)andQiluPetrochemicalBranchCompanyhas

简介：降雨在海表面上有二重要效果，包括咸度减少并且表面变得更不平，它在L乐队海表面放射率上有进一步的影响。用宝瓶座和TRMM3B42配对数据集的调查显示检索的海表面咸度(SSS)被现在的宝瓶座算法与数字模型产量相比低估，特别在高雨率的情况下。例如，当雨率是25mm/h时，在观察卫星的SSS之间的偏爱和数字模型SSS是约2。偏爱能被财务为导致雨的粗糙消除，它被产生雨的戒指波浪光谱通常建模。雨光谱将是进为雨影响的海表面放射率的模拟的小斜坡近似(SSA)模型的输入。与理论模型一起的比较显示对更合适的雨spectrumis的实验模型在模拟被使用。进一步，雨光谱的系数被与2year宝瓶座和TRMM配对数据集的观察适合模拟修改。计算证实海表面放射率以风速度和雨率增加。雨率导致的增加在低雨率和低风速度的情况中是快速的。最后，包括雨光谱的海表面放射率的一个修改模型被在2014年5月使用配对数据集建议并且验证。与观察相比，导致雨的海表面放射率的偏爱近似由修改modelis模仿了1e4,和RMSE比1e3稍微大。与使用更多的配对数据，在模型之间的thebias检索了海表面咸度和observationsmay进一步被改正，并且RMSE可以在低雨率和低风速度的情况中被归结为不到1。

简介：摘 要：压实是影响SAC25沥青混合料结构形成和使用性能的关键环节，采用3种压实试验方法--标准马歇尔击实、大型马歇尔击实法和SGC旋转压实研究SAC25沥青混合料的压实效果和压实特性，研究结果表明：大型马歇尔击实法和SGC旋转压实法成型的SAC25沥青混合料密度与现场钻芯试件的密度接近, 是成型SAC25沥青混合料的合适方法, 其成型密度平均是标准马歇尔密度的1.02～1.03倍；旋转压实试验的密度曲线能够较好地反映SAC25沥青混合料的压实特性, 与车辙试验结果的相关性良好。

简介：ToinvestigatethechangesofthebiochemicalcompositionofAmericanshad(Alosasapidissima)eggsandlarvaeatembryonicandearlylarvalstages,sampleswerecollectedatdifferentdevelopmentstagesfromartificialfertilizationtotheendofyolkabsorptionincluding2h,12hand30hafterfertilizationandnewlyhatchedlarvaeincluding1and3daysafterhatching.Thecompositionoflipid,fattyacids,proteinandaminoacidswereanalyzed.Thecontentoftotalproteinexhibitedadecreasingtrendduringembryogenesisandlarvaldevelopment,andasignificantreductionwasdetectedafterhatching(P<0.05).Thetotallipidcontentremainedrelativestable.Asignificantreductionwasdetectedinalmostallaminoacidsafterhatchingexceptforglycine(P<0.05),whileasignificantdecreasewasfoundinthecontentofcysteine,proline,tyrosine,valine,isoleucine,leucineandphenylalanineduringtheyolk-sacphase(P<0.05).Ontheotherhand,allthegroupsoffattyacidsremainedstableduringtheperiodofembryogenesis.Butafterhatching,asignificantdecreasewasfoundinthecontentofC18:2n-6,C18:3n-6,SFAandratioofEPA/ARA(P<0.05),whileasignificantincreasewasfoundinthecontentofC18:3n-3,C20:4n-6,C22:6n-3andratioofn-3/n-6(P<0.05).Inconclusion,thecombineddatasuggestedthatAmericanshadutilizestheproteincontentaspreferentialenergysubstratesduringembryonicandearlylarvaldevelopmentswithsomespecificityintheconsumptionofdifferentaminoacids.

简介：Sac-A-B1#双肩包是一款百诺创新设计的多功能摄影包,其另类的设计风格令人无法相信这是一款装满贵重摄影器材的摄影包。Sac-A-B1#双肩摄影包分上下两层结构设计,可拆式活动内袋提高了功能上的灵活

简介：2016年5月6日，第五届全国核能标准化技术委员会（SAC／TC58）与第六届全国核仪器仪表标准化技术委员会（SAC／TC30）第一次工作会议在北京召开。国家标准化管理委员会（以下简称国家标准委）工业二部副主任王莉、国家国防科技工业局（以下简称国防科工局）系统工程二司副司长高洪滨、中国核工业集团公司总工程师雷增光、

简介：2007年1月22～24日，在珠海召开了“全国防爆电气设备标准化技术委员会（SAC／TC9）四届三次会议”。来自全国各地的本届委员和特邀代表及8项标准制修订工作组成员共61人参加了会议，其中包括上级主管部门国家安全生产监督管理总局、中国电器工业协会和南阳防爆电气研究所的领导。