简介：Bonedefectisoneofthemostcommondiseasesinclinic.Existingtherapeuticapproacheshaveencounteredmanyproblems,suchaslackofautogenousallogeneicboneandimmunologicalrejectiontoallogeneicimplant.Synthetichydroxyapatite（HA）providedsolutionsforbonerepair,sincetheHAisthemaininorganiccomponentofanimals＇bone.AlthoughHAhasgoodbiocompatibility,butonlythelimitedosteogeniccapability,whichisofsignificanceformodernbonerepairmaterials.Siisanessentialtraceelementinbonetissue,andithasbeendemonstratedtobeabletopromoteboneformation.Therefore,silicate-dopedhydroxyapatite（Si-HA）mayserveasapromisingmaterialforbonerepair,andpromoteboneregenerationintherepair.ThecurrentreviewdiscussesdevelopmentofSi-HA,focusingonitspreparationandcharacterization,invitroandinvivoevaluationsofthematerial,positiveeffectofSi-HAonpromotingboneformationinclinicalapplications,andmolecularmechanisminvestigationofsuchpromotiveeffect.