简介：Thesuddenoutbreakofsevereacuterespiratorysyndrome(SARS)in2002promptedtheestablishmentofaglobalscientificnetworksubsumingmostofthetraditionalrivalriesinthecompetitivefieldofvirology.WithinmonthsoftheSARSoutbreak,collaborativeworkrevealedtheidentityofthedisastrouspathogenasSARS-associatedcoronavirus(SARS-CoV).However,althoughtherapididentificationoftheagentrepresentedanimportantbreakthrough,ourunderstandingofthedeadlyvirusremainslimited.Detailedbiologicalknowledgeiscrucialforthedevelopmentofeffectivecountermeasures,diagnostictests,vaccinesandantiviraldrugsagainsttheSARS-CoV.ThisarticlereviewsthepresentstateofmolecularknowledgeaboutSARS-CoV,fromtheaspectsofcomparativegenomics,molecularbiologyofviralgenes,evolution,andepidemiology,anddescribesthediagnostictestsandtheanti-viraldrugsderivedsofarbasedontheavailablemolecularinformation.

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简介：客观：与严重煽动性的反应症候群(先生)在创伤的病人调查甲状腺荷尔蒙的引申。方法：有严重先生的五十个创伤的病人被注册并且根据他们是否介绍了multiorgandysfunction症候群(MODS)把组划分了成二。甲状腺荷尔蒙大小被拿，包括totaltriiodothyronine(TT3)，全部的甲状腺素(TT4)，免费triiodothyronine(FT3)，免费甲状腺素(FT4)和甲状腺刺激荷尔蒙(TSH)。尖锐生理学和长期的健康评估Ⅱ(APACHEⅡ)20根据临床的数据被计算。恢复或恶化的结果被记录，以及从到时间甲状腺荷尔蒙的先生的发作的时间的长度被测量。结果：Euthyroid病了的症候群(S字)在45cases.TT3水平被介绍否定地与APACHEH分数被相关(r=-0.330,P<0。05)，并且TT3/TT4value否定地与先生的持续时间被相关(r=-0.316,P<0.05)。没有MODS，在MODS病人的TT3，TT4和FT3levels是比那些显著地低的(P<0.05)。没有MODS，给低TT4或FT4的MODS病人比那些经常铺平更多(P<0.05)。与在正常TSH组的病人相比，有有的减少的TSH的病人降低T3，T4，恢复率和更高的APACHEⅡ分数，MODS发生，但是二个组之间没有差别(P>0.05).Conclusions：有严重先生的损伤病人有高可能性得到S字，它更经常并且严重地发生在MODS病人。它在甲状腺轴上显示出先生的影响。Withthe坚持和先生的恶化，有甲状腺荷尔蒙的进步减小。

简介：Objective:Tostudytheclinicaltherapeuticeffectofanisodamineonrespiratoryfunctionafterseverebraininjury.Methods:Ninetypatientswithrespiratorydysfunctionfollowingseverebraininjuryweredividedintotwogroups:atreatmentgroup(n=45,treatedwithroutinetherapyplusanisodamine)andacontrolgroup(n=45,treatedwithroutinetherapyonly).Thepulmonaryventilationfunctionandoxygenationfunctionwerecomparedbetweenthetwogroups.Results:Inthetreatmentgroup,12hoursaftertreatmenttherespiratoryratereduced,thepartialpressureofcarbondioxide(PCO2),thepartialpressureofoxygeninarterialblood(PaO2)andoxygenationexponentincreased,thedeadspaceventilationdoseandthepulmonaryalveolus-partialpressureofarterialoxygendifferencedecreased,andtheventilationfunctionoftherespiratorytractandpulmonaryoxygenationfunctionimproved.Therewasasignificantdifferencebetweenthetwogroups(P<0.01).Noside-effectwasfoundexceptaslightincreaseofintracranialpressureandheartrate.Conclusions:Anisodaminecanimprovepulmonaryventilationfunctionandoxygenationfunctionanddecreasetheincidenceofhypoxemiamarkedly.Itiseffectiveintreatingrespiratorydysfunctionafterseverebraininjury.

简介：WemadeclinicalobservationsonthetherapeuticeffectofacupunctureonacuteupperrespiratorytractinfectionandcomparedwiththeeffectofparacetamolandAntondine,Theresultshowedthatacupuncturetherapycouldallayfevermorerapidlythandrugs,solongasthedifferentiationofsyndromesiscorrectandtheacupointisselectedproperly.

简介：PatientswithAcuteCoronarySyndrome(ACS)areaclinicalcontinuum-withpatientspresentingwithunstableanginaononeend,withpatientswithSTelevationmyocardialinfarction(STEMI)attheotherendofthespectrum.Inbetweenarethosewithnon-ST

简介：Severeacutepancreatitis(SAP)cancausesystematicinflammatoryresponsesyndrome(SIRS),whichleadstoinjuryorfailureoftheinternalorgansandsystems.1Amongthem,acuterespiratorydistresssyndrome(ARDS)isasevereorfatalcomplication.Inthisarticle,theearlypreventivetreatmentforSAPcombinedwithlunginjureisstudied.

简介：瞄准：检验在试验性的严重尖锐胰腺炎(树液)抵销抗体的反高的活动性组盒子1的效果(HMGB1)。方法：傻瓜被在C3H/HeN老鼠创造关上的十二指肠的循环劝诱。傻瓜在抵销抗体(200大杯)的anti-HMGB1的intraperitonealinjection以后立即被劝诱。胰腺炎，机关损害(肝，肾和肺)，和到胰的细菌的translocation的严厉被检验在树液的正式就职以后的12h。结果：显著地抵销抗体的Anti-HMGB1在树液改进了浆液淀粉酶水平的举起和胰和肺的组织学的改变。Anti-HMGB1抗体显著地也改善了在SAP.However的浆液丙氨酸aminotransferase和creatinine的举起，anti-HMGB1抗体变得更坏细菌的translocation到胰。结论：BlockadeofHMGB1稀释了树液的发展并且联系了机关机能障碍，建议HMGB1may充当为在树液的煽动性的反应和机关损害的一个关键调停人。

简介：ObjectivesTostudythestatusoffibrinolyticinhibitioninpatientsofacutecoronarysyndrome(ACS)complicatedwithtypeⅡdiabetesmellitus(NIDDM)andtoevaluatetheeffectoffibrinolyticinhibitiontotheclinicalprognosis.MethodsTypeⅡdiabetesmellituswasdefinedbyADA1997/WH01998criteria.Thesubjectsweredividedintotreatmentgroupsthatincluded39patientsofACSwith20casesofacutemyocardiacinfarction(AMI),36patientsofACS+NIDOMwith20casesofAMI.Twentycasesofhealthypeoplewererandomizedtocontrolgroup.Theplasmaleveloftissuetypeplasminogenactivator(t-PA),plasminogenactivatorin-hibitortype-1(PAI-1)andplasmaD-dimerweredetectedbyusingelisatechnique.TheindexofstatueinfibrinolysiswasdetectedwiththeplasmalevelofD-dimerandtherateofPAI-1/D-dimerinpercentage.ThisindexwasusedtoevaluatethefibrinolyticinhibitionandtheclinicaloutcomeinallthepatientswithAMIintreatmentgroups.TheclinicaloutcomeinpatientswithAMIconsistedoftherateofreperfusion,theincidencesofreinfarction,severi-ousarrhythmia,pumpfailureanddeathintheearlyperiodofAMI.ResultsTheplasmalevelofPAI-1andD-dimerwashigherinthetwotreatmentgroupsthanthatinthecontrolgroup(P<0.01).TheplasmalevelofPAI-1significantlyhigherinACS+NIDDMpatientsthanthatinACS(P<0.05),buttheplasmalevelofD-dimerraisedfrombasiclevelwassignificanflylowerinACS+NIDDMthanthatinACS(P<0.05).TherateofPAI-1/D-dimerinpercentagewassignificantlyhigherinACS+NIDDMthanthatinACSorincontrolgroup(P<0.01).ForAMIpatientsintwotreatmentgroups,therateofreperfusionafterthethrorabolytictherapywassignifi-candylowerinACS+NIDDMthanthatinACS(P<0.01).TherateofincidencesinpumpfailurewassignificantlyhigherinACS+NIDDMthanthatinACStoo(P<0.05).Themorbidityofseveriousarrhythmia,re-infarctionandthemortalitywerealsohigherinACS+NI

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简介：Therespiratorysystemhastwoprincipalpurposes-tomaintainadequatearterialPaO2,andtoregulatearterialPaCO2andtherebymaintainastableacid-basestate.Botharenecessarytosustainnormaltissuemetabolism.Respiratoryfailurecanbedefinedintwoways:

简介：Objective:Tostudythechangesofpartialpressureofbraintissueoxygen(PbtO2)andbraintemperatureinacutephaseofsevereheadinjuryduringmildhypothermiatherapyandtheclinicalsignificance.Methods:Onehundredandsixteenpatientswithsevereheadinjurywereselectedanddividedintoamildhypothermiagroup(n=58),andacontrolgroup(n=58)accordingtooddandevennumbersofhospitalization.WhilemildhypothermiatherapywasperformedPbtO2andbraintemperatureweremonitoredfor1-7days(mean=86hours),simultaneously,theintracranialpressure,rectumtemperature,cerebralperfusionpressure,PaO2andPaCO2werealsomonitored.Thepatientswerefollowedupfor6monthsandtheprognosiswasevaluatedwithGOS(Glasgowoutcomescale).Results:ThemeanvalueofPbtO2within24hourmonitoringinthe116patientswas13.7mmHg±4.94mmHg,lowerthanthenormalvalue(16mmHg±40mmHg)ThetimeofPbtO2recoveringtothenormalvalueinthemildhypothermiagroupwasshortenedby10±4.15hourscomparedwiththecontrolgroup(P<0.05).Thesurvivalrateofthemildhypothermiagroupwas60.43%,higherthanthatofthecontrolgroup(46.55%).Aftertherecoveryofthebraintemperature,PbtO2increasedwiththeriseofthebraintemperature.Conclusions:Mildhypothermiacanimprovethesurvivalrateofsevereheadinjury.ThetechniqueofmonitoringPbtO2andthebraintemperatureissafeandreliable,andhasimportantclinicalsignificanceinjudgingdiseaseconditionandinstructingclinicaltherapy.

简介：Theprimarysymptomsofrespiratorydisordersarebreathlessness,chestpainandcough,whichmaybeassociatedwithsputumproduction.However,disordersofthelungscanproducedistantsymptoms(e.g.non-metastaticmanifestationsoflungcancer),andnon-respiratoryconditionssuchasanaemiaandmetabolicacidosscancauseberathlessness.Adequateassessmentofanypatientrequiresafullclinicalhistoryandexamination.Thiscontributionconsidersaspectsdirectlyrelevanttotherespiratorysystem.

简介：Treated55casesofacutelumbarsprainonlywithacupuncturingCuanzhu(BL2).Afterthreetreatments,53caseswerecured,and2caseswereimprovement.

简介：Careinoidsyndromeisaconstellationofsymptoms,mostobviouslyflushinganddiarrhoea,causedbyreleaseofhormonesandothersultancesfromaCarcinoidtumour,whichisatypeofneuroendoerinetumour.

简介：共分析了50篇丈章，分别采用单纯针剌法，针剌结合其他疗法，耳穴贴压疗法和其他疗法进行治疗。有39篇文章有明确的诊断标准，其中《实用中西医结合诊断治疗学》，Kupperman评分和《中医病证诊断疗效标准》。治疗组涉及病例总数2946例，临床疗效最高达100％，最低为58、1％。有16篇设立了对照组。15篇进行了辨证分型，共27种证型，有肝肾阴虚，睥肾阳虚，肾阳虚，肾阴虚，心肾不交和肝郁等。针灸治疗更年期综合征具有一定效果，但缺少严格的随机对照试验(RCT)。

简介：AcuterheumaticfeverisinitiatedbygroupAstreptococcalphar-yngitis.Thisisfollowedbyalatentperiodof2-6weeks,afterwhichtheclinicalsyndromeofacuterheumaticfeverevolves,characterizedbypolyarthritis,carditis,chorea,erythemamarginatumandsubcutaneousnodules.Thesefeaturesmayoccursinglyorinanycombination.

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简介：Thecutaneousnerveentrapmentsyndromeisnamedthat,thecutaneousnerve'sfunctionaldisordercausedbysomechronicentrapment,moreoverappearsaseriesofnerve'sfeelingobstacle,vegetativenervefunctionobstacle,nutritionobstacle,evenmotorfunctionobstacleinvariousdegree.