简介:AbstractIntroduction:Verrucous carcinoma is a rare variant of squamous cell carcinoma. It generally grows exogenously and bone erosion is rare. Here we present a case of verrucous carcinoma on the foot with toe absence.Case presentation:A 64-year-old man presented with a 6-year history of a slowly growing exogenous hyperkeratotic verrucous lesion on the right fifth toe, which had been absent for 1 year. Before the lesion appeared, he had undergone nail extraction on this toe. The culture of fungi and mycobacteria were negative. Three-dimensional computed tomography showed that the fifth toe of the right foot was absent. Histopathological examination showed that the lesion was exogenous and verrucous and exhibited moderate keratinocyte hyperplasia. Combined with clinical manifestation and histopathological examination, verrucous carcinoma is suggested. The lesion was surgically excised, and the patient was followed up for more than 6 months without recurrence.Discussion:Verrucous carcinoma is an exophytic tumor with verrucous growth at the beginning, which can invade deep tissues and even cause limb mutilation. When encountering a patient with a wart-like plaque on the foot that responds poorly to conventional treatments, clinicians should maintain a high degree of clinical vigilance and a low threshold for biopsy.Conclusion:We observed a rare outcome of toe absence associated with verrucous carcinoma. Therefore, early diagnosis of verrucous carcinoma is very important. Surgical excision is an effective treatment at present. Extensive resection is usually required to avoid recurrence.
简介:Background:Numerousstudiesabouttheinteractionbetweenfootwear(andbarefoot)andkinematicandkineticoutcomeshavebeenpublishedoverthelastfewyears.Recentstudieshoweverleadtotheconclusionthattheassumedinteractionsdependmainlyonthesubjects'experienceofbarefoot(BF)walking/running,thepreferredrunningstrikepattern,thespeed,thehardnessofthesurface,thethicknessofthemidsolematerial,andtherunners'levelofability.Theaimofthepresentstudywastoinvestigatelowerlegkinematicso\'BFrunningandrunninginminimalrunningshoes(MRS)toassesscomparabilityofBFkinematicsinbothconditions.Tosystematicallycomparebothconditionswemonitoredtheinfluencingvariablesdescribedaboveinourmeasurementsetup.WehypothesizedthatrunninginMRSdoesnotalterlowerlegkinematicscomparedtoBFrunning.Methods:Thirty-sevensubjects,injury-freeandactiveinsports,ranBFonanEVAfoamrunway,andalsoranshodwearingNikeFree3.0onatartanindoortrack.Lower-leg3Dkinematicswasmeasuredtoquantifyrearfootandanklemovements.SkinmarkerswereusedinbothshodandBFrunning.Results:Allrunnersrevealedrearfootstrikepatternwhenrunningbarefoot.DifferencesbetweenBFandMRSrunningoccurredparticularlyduringtheinitialstancephaseofrunning,bothinthesagittalandthefrontalplanes.BFrunningrevealedaflatterfootplacement,amoreplantarflexedanklejointandlessinvertedrearfootattouchdowncomparedtoMRSrunning.Conclusion:BFrunningdoesnotchangethelandingautomaticallytoforefootrunning,especiallyafterasystematicexclusionofsurfaceandotherinfluencingfactors.TheNikeFree3.0mimicssomeBFfeatures.Nevertheless,changesindesignoftheNikeFreeshouldbeconsideredinordertomimicBFmovementevenmoreclosely.
简介:摘要:本文基于表观遗传经济动态能力理论,构建基于EED- TOE-SEM理论模型,分析外贸企业数字化转型机制, 基于表观遗传学的经济隐喻,将外贸企业适应数字经济环境并转型的过程,与生物细胞适应环境、改变表型并遗传的过程相对应起来,构建广东外贸企业数字经济转型的典型模式SEM理论模型,并为进一步深入讨论和分析数字经济对广东外贸企业应对疫情路径选择的可行性进行SEM理论模型构建的模型设计。
简介:摘要混凝土框架剪力墙结构的性能,使它收到了这个行业的广泛欢迎,特别是在我国高层建筑中应用广泛。经济社会的发展使得人口数量越来越多,高层建筑的数量要求也不断增多,但是近年来城市化的不断发展使得人口规模不断扩张,城市用地越来越紧张,因为土地资源有限,所以只能发展高层建筑节约地面空间,高层建筑能够有效的解决土地资源稀缺和人们住宿的问题,因而受到了广泛的关注,而混凝土框架结构作为高层建筑的重要支持,能够为高层建筑的安全性和稳定性作出重要的贡献。鉴于此,笔者根据自己的工作经验分析了混凝土框架剪力墙结构的抗侧刚度优化措施,希望能为同行提供一定的参考。
简介:"教育公平""高质量的教育""核心素养""减负"等已成为流行热词,在新时代背景下实践者对究竟要"教什么"需要再思考。经济合作与发展组织(简称经合组织,OECD)于2015年启动了"教育2030:未来的教育与技能"项目,项目中启动了"面向2030的学习指南"讨论,旨在开发一种新的学习框架,描述需要用什么样的能力来塑造未来的一代。学习框架包括知识、技能、态度和价值观;个人和社会的福祉;变革性能力,通过反思、预期和行动的过程,调动知识、技能、态度和价值观,以便发展与世界接触所需的相互关联的能力。此外,"教育与技能2030项目"专家组也提出了设计教育体系与课程改革的指导原则,包括概念、内容和主题设计以及流程设计。