简介：Aim:Toevaluatetheefficacyandsafetyoftransurethralapplicationofalprostadil(MUSE.)forthetreatmentoferectiledysfunctioninIndonesians.Methods:Twentyerectiledysfunctionpatientsagedbetween32-74yearsoldwererecruitedinthisstudy.Theinclusioncriteriawereasfollows:1)adultmales18yearsorolderwithasubjectivecomplaintorerectiledysfunction,2)toprovidewritteninformedconsent,3)toagreenottouseotherformsoftreatmentforerectiledysfunction,4)fulfillthescreeninglaboratoryvalues.Part1,eligiblepatientsweretitratedintheclinicstartingwithadoseof250μgandproceedinastepwisemannerto500μgand1000μgonseparateclinicvisitsuntiltheyidentifiedadosethatproducedasatisfactoryresponse.Theintervalbetweeneachin-clinictitrationwas2-3days.Eachin-clinictitrationdosewasevaluatedat15minintervalsoveraonehourperiodforerectionassessment,bloodpressureandpulse.Part2,patientsusedMUSEathomeforthreemonthsatthedoseidentifiedduringtheinclinictitration.Monthlyinterimvisitswererequiredforpatientfollow-upanddrugdistribution.Attheendofthestudy,patientshadanotherlaboratory(excepttestosterone,onlyassayedinscreeningprocedure)andphysicalexamination.Results:Theetiologyoferectiledysfunctionwaspsychologicalin5patientsandorganicin15patients.The65%ofthepatientsachievedtheerectionscaleof4or5eitherintheclinicorathome,10%achievedthescaleof4athome,butnotintheclinic,and25%onlyachievedthescaleof2or3withthehighestdoseof1000μgeitherintheclinicorathome.Nosignificantdifferenceswerefoundinbiochemicalexaminationbeforeandafterthestudy.The60%ofthepatientswhoachievederectionscale4or5continuedtouseMUSEuntiltheendofthestudy,while40%ofthemcomplainedofpainatthetimeofMUSEapplication,duringerectionand/orduringintercourse.Theywithdrewfromthestudy.Conclusion:Transurethral