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12 个结果
  • 简介:AjointventurenamedRareEarthMagnetCom-pany(REMCO)wassetupbyBaotouSteelandRareEarthCompanyofChinaandBankhouseGroupofUSA.Theceremanyofsigningtheagreementbe-tweenthetwosideswasheldinHuhehot,capitalcityofInnerMongoliaJuly27,1992.Chinaholdsap-proximately80%oftheworldtotalrareearthre-sources,andrareearthsarenowanimportantcompo-nentinmakingadvancedmagnets.ItistheintentionofthetwosidestoformanequalpartnershipinwhichChinawouldsharewiththeUnitedStatesthehighest

  • 标签: Baotou VENTURE holds SIGNING PARTNERSHIP compo
  • 简介:On6thSeptember2012,InternationalExpertsCommitteeonPopulationAgingLongevity(IECPAL)wasestablishedinHainan.ParticipantsoftheSecondSessionofInternationalWorkshoponPopulationAgingLongevitydiscussedandpassedtheIECPALConstitution"hereinafterreferredastheExpertsCommitteeConstitution".TheprimarystageofIECPALSecretariatwassponsoredbyCommitteeonPopulationoftheSocietyforResearchandAnalysisofChina’sSocialandEconomicSystems,andinternationalcooperativeagenciesinJapan,RepublicofKoreaandothercountries.IECPALisformedbyexpertsandscholarsfromthefieldsofnatural

  • 标签: 专家委员会 人口老龄化 国际研讨会 长寿 经济系统 国际合作
  • 简介:On7July2011,ShanghaiPopulationandFamilyPlanningGuidance&ServiceCentrewasestablishedtoreorganizeresourcesforenhancedstandardoffamilyplanningguidanceandservice.ItisreportedthattheCentrewill

  • 标签: 计划生育 人口 上海
  • 简介:TheestablishmentoftheStatePowerGridDevelopmentCorpLtd(SPG)wasofficiallyannouncedonJune18,markingthegovernment’sdeterminationtoformanationwideunitedpowernetworktomakethebestofpowergeneratingcapability.TheState-ownedcorporation,with2.5billionyuan($301million)worthofoperatingcapitalraisedbythegovernment,willberesponsibleforinvestment.constructionandmanagementofthepowertransmissionandsubstationprojectsinvolvedintheconstructionoftheThreeGorgesProject.

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  • 简介:BACKGROUND:Kainicacidcanbeusedtoinduceamodelofepilepsybysystemicinjection,suchasintraperitonealorsubcutaneousinjection.Individualratshavedifferentresponsestokainicacid,thereforehighdosesofdrugarerequiredandthesuccessrateofmodelinductionislow.Itisnecessarytodevelopanimprovedmethodtoestablishatemporallobeepilepsy(TLE)animalmodel.OBJECTIVE:Toexploreaneconomic,stableandefficientmethodofestablishingaTLEanimalmodel.DESIGN,TIMEANDSETTING:Acompletelyrandomized,controlledstudy.TheexperimentswereperformedintheCellularFunctionLaboratoryofthePhysiologyDepartment,AnhuiMedicalUniversityfromMarchtoJuly2007.MATERIALS:TwentyadultmaleWistarrats,weighing230–260g,wereprovidedbytheExperimentalAnimalCentreofNanjingMedicalUniversity.KainicacidwaspurchasedfromSigmainUSA.TypeSN-2stereotaxicapparatuswasmadebyNarishgeinJapan.METHODS:Wistarratswererandomlydividedintoakainicacid(KA)group(n=12)andanormalsaline(NS)group(n=8).Forintrahippocampalmicroinjection,aburrholewasdrilledintheskullatthefollowingstereotaxiccoordinates:anteroposterior(AP)4.1mmcaudaltobregma;lateral(ML)4.2mmrightlateraltothemidline.RatsintheKAgroupwereinjectedwith2.5μLKA(0.4g/L)intothecenteroftheCA3region,whileintheNSgroupthesamevolumeofNSwasinjectedintothesamesite.MAINOUTCOMEMEASURES:Bothgroupsweremonitoredunderavideocapturesystemfor12weekstorecordspontaneousseizures.Intracranialeletroencepholograph(IEEG)recordingsinvivowereperformedafterthebehavioralobservations.AftertheIEEGrecordings,hippocampiwereprocessedintocoronalsections.NisslandTimmstainingswerethenperformedtoobserveandconfirmpathology.RESULTS:Twentyratswereinvolvedinthefinalanalysis.Behavioralobservations:theearliestspontaneousonsetofepilepsyappeared2weeksafterinjectionofKA.Eightratshadspontaneouson

  • 标签: 癫痫 颞骨 显微注射 治疗方法
  • 简介:ObjectivesToassesswhetherstatinsreduceall-causemortalityandCVeventsinelderlypeoplewithoutestablishedCVdisease.BackgroundSinceageingofthepopulationissteadilyraising,preventionofcardiovascular(CV)diseaseintheelderlyisrelevant.InelderlypatientswithpreviousCVevents,useofstatinsisrecommendedbyguidelines,whereasbenefitsofthesedrugsinelderlysubjectswithoutpreviousCVeventsarestilldebated.MethodsRandomizedtrialscomparingstatinsversusplaceboandreportingall-causeandCVmortality,myocardialinfarction(MI),stroke,andnewcanceronsetinelderly(>65yearsold)subjectswithoutestablishedCVdiseasewereincluded.ResultsEighttrialsenrolling24,674subjects(42.7%females;meanage73.0+2.9;meanfollow-up3.5+1.5years)wereincludedinanalyses.Statins,comparedtoplacebo,significantlyreducedtheriskofMIby39.4%(relativerisk[RR]:0.606[95%confidenceinterval(CI):0.434to0.847];P=0.003),aswellastheriskofstrokeby23.8%(RR:0.762[CI:0.626to0.926];P=0.006).Incontrast,theriskofall-causedeath(RR:0.941[CI:0.856to1.035];P=0.210)andofCVdeath(RR:0.907[CI:0.686to1.199];P=0.493)werenotsignificantlyreduced.Newcanceronsetdidnotdifferbetweenstatin-comparedtoplacebotreatedsubjects(RR:0.989[CI:0.851to1.151];P=0.890).ConclusionsPInelderlysubjectsathighCVriskwithoutestablishedCVdisease,statinssignificantlyreducetheincidenceofMIandstroke,butdonotsignificantlyprolongsurvivalintheshort-term.

  • 标签: 心血管疾病 老年人 绸缎 他汀类药物 死亡率
  • 简介:Anewdoubledhaploid(DH)ricepopulationwasestablishedfromacrossbetweenWBPH-resistantjaponicaChunjiang06(CJ-06)andsusceptibleindicaTN1.SuckinginhibitoryandovicidalresistanceoftheDHricelineswereevaluatedonthebasisofnon-preferenceresponseofWBPHimmigrantsandhoneydewexcretionbyWBPHfemales,andappearanceofwaterylesionsinthenecroticdiscolorationofleafsheathsovipositiedbyWBPH,respectively.BoththemajorgeneresistancetoWBPH,suckinginhibitoryandovicidalresistance,showed1(resistant):1(susceptible)segregationratiointheDHpopulation.RelativedensityofWBPHpopulationsanddamagescoresintheDHpopulationindicatedcombinedfunctionsofboththemajorresistancegenesaswellasQTLsaffectingthehostplantresponsetoWBPHinfestations.Thus,thenewlydevelopedCJ-06/-I-N1DHpopulationcouldbeausefulmaterialtoanalyzemajorgenesandQTLsforWBPHresistanceinjaponicarice.

  • 标签: 两系杂交水稻 白背飞虱 抗虫性 表型表达 品种抗性
  • 简介:Directintratumoralintroductionoftherapeuticorregulatorygenesisadevelopingtechnologywithpotentialapplicationforcancergenetherapy.Macrophageinflammatoryprotein-1beta(MIP-1β)isachemokinewhichcanchemoattractimmunecellssuchasTcells.Inthepresentstudy,murinecolorectaladenocarcinomaCT26cellsweretransfectedwitharecombinantadenovirus(AdhMIP-1β)carryingthehumanMIP-1βgene.24hpost-transfection,hMIP-1βlevelsreachedapproximately980pg/mlinsupernatantsof106hMIP-1β-transfectedCT26cells.Moreover,thesupernatantsexhibitedchemotacticactivityforCD8+Tcells,CD4+Tcells,NKcellsandimmatureDCs.IntratumoralinjectionofAdhMIP-1βsignificantlyinhibitedtumorgrowthandprolongedthesurvivaltimeoftumor-bearingmice.IntratumoralhMIP-1βgenetransferalsoinducedpowerfultumor-specificCTLresponsesinvivo.ThetherapeuticeffectsofhMIP-1βgenetherapyweregreatlyreducedfollowinginvivodepletionofbothCD4+andCD8+Tcells,butwereunaffectedbydepletionofsingleTcellsubsets.ImmunecelldepletionexperimentsalsorevealedthatNKcellsplayedanimportantroleinhMIP-1β-inducedantitumorresponses.TheseresultssuggestthatintratumoralexpressionofhMIP-1βhasthepotentialeffecttoinducehostantitumorimmunityandmayprovetobeausefulformofcancergenetherapy.

  • 标签: 输尿管 基因表达 MIP-1Β 诱导作用 抗菌反应 肿瘤
  • 简介:AbstractPropose:In this study, we re-assessed the criteria defined by the radiological society of North America (RSNA) to determine novel radiological findings helping the physicians differentiating COVID-19 from pulmonary contusion.Methods:All trauma patients with blunt chest wall trauma and subsequent pulmonary contusion, COVID- 19-related signs and symptoms before the trauma were enrolled in this retrospective study from February to May 2020. Included patients (Group P) were then classified into two groups based on polymerase chain reaction tests (Group Pa for positive patients and Pb for negative ones). Moreover, 44 patients from the pre-pandemic period (Group PP) were enrolled. They were matched to Group P regarding age, sex, and trauma-related scores. Two radiologists blindly reviewed the CT images of all enrolled patients according to criteria defined by the RSNA criteria. The radiological findings were compared between Group P and Group PP; statistically significant ones were re-evaluated between Group Pa and Group Pb thereafter. Finally, the sensitivity and specificity of each significant findings were calculated. The Chi-square test was used to compare the radiological findings between Group P and Group PP.Results:In the Group PP, 73.7% of all ground-glass opacities (GGOs) and 80% of all multiple bilateral GGOs were detected (p < 0.001 and p = 0.25, respectively). Single bilateral GGOs were only seen among the Group PP. The Chi-square tests showed that the prevalence of diffused GGOs, multiple unilateral GGOs, multiple consolidations, and multiple bilateral consolidations were significantly higher in the Group P (p= 0.001, 0.01, 0.003, and 0.003, respectively). However, GGOs with irregular borders and single consolidations were more significant among the Group PP (p = 0.01 and 0.003, respectively). Of note, reticular distortions and subpleural spares were exclusively detected in the Group PP.Conclusion:We concluded that the criteria set by RSNA for the diagnosis of COVID-19 are not appropriate in trauma patients. The clinical signs and symptoms are not always useful either. The presence of multiple unilateral GGOs, diffused GGOs, and multiple bilateral consolidations favor COVID-19 with 88%, 97.62%, and 77.7% diagnostic accuracy.

  • 标签: Chest wall CT Contusion COVID-19 RSNA criteria Trauma
  • 简介:BackgroundItiswellknownthattherewasasignificantlinkbetweenpreproceduralbloodglucoselevelsandshort-termandlong-termadverseoutcomesinpatientsundergoingelectivePCI.However,theroleofpre-proceduralbloodglucoselevelsasapredictorofadverseeventsinCKDpatientswhounderwentPCIoutofestablisheddiabeteshasyettobeidentified.MethodsInourstudy,weconductedaprospectivestudyof331acutecoronarysyndrome(ACS)patientswithCKDwhounderwentPCIoutofestablisheddiabetes.Patientsweredividedintotwogroupsbasedonpre-proceduralglucoselevels(hypoglycemia<7.0mmol/L;hyperglycemia≥7.0mmol/L).Allpatientswerefollowedupprospectivelyformajoradversecardiovascularevents(MACEs)andmortalityfor6months.ResultsInourcohort,hyperglycemiapatientsreportedahigherincidenceofin-hospitalmortalitythanhypoglycemiapatients(7.5%vs.0%,P<0.001).Hyperglycemiapatientsreportedasignificantlyhigherrateof6-monthMACEs(10%vs.2.4%,P=0.007),allcausemortality(7.5%vs.1.6%,P=0.015),andcardiovascularmortality(6.2%vs1.6%,P=0.041)comparedwithhypoglycemiapatientswithpre-proceduralglucoselevels<7.0mmol/L.Multivariateanalysisdisclosedthatapre-proceduralglucoselevel≥7.0mmol/LwasasignificantindependentpredictorofMACEs(OR=2.53,95%CI1.68-17.15,P=0.004),allcausemortality(OR=4.6,95%CI1.10-18.84,P=0.036),andcardiovascularmortality(OR=6.2,95%CI1.53-24.94,P=0.011)at6monthsinpatientsafterPCI.ConclusionThestudysuggestedthatpre-proceduralglucoselevelsareassociatedwithshort-termcardiovascularoutcomeCKDpatientswhounderwentPCIwithoutestablisheddiabetesinthesettingofACS.

  • 标签: 心血管疾病 血糖水平 糖尿病 患者 程序 事件