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简介：Theresearchersreviewedbestpracticesschoolleadersshouldhaveandexploredtheeffectiveuseofcommunicationstechnologytosuperviseinternsintheirfinalsemesterofinternship.Thestudyisacomparisonofwhatinternsreportedaseffectivenessintheirpreparation,performancelevel,andoverallperceivedsupervisorsupport.Otherdatarelatedtolevelofconfidenceintheirpreparation,experiences,andactivitieswerecollectedfrominternsusinga12-questionsurvey.Conclusionsdrawnfromthissmallstudyseemedtoindicatethatinternscanfeelsupportedintheinternshipexperiencewhenthequalityoftheexperiencewaspreservedregardlesstowhethertheyreceivedsupervisionelectronicallyorviaface-to-facevisits.

简介：否定阶段的诺思大西洋摆动(NAO)事件通常比积极阶段的强壮，即，有NAO的阶段力量不对称现象。在这个工作，我们用有条件的非线性的最佳的不安(CNOP)探索NAO的这不对称现象方法与一三水平全球伪因地球自转而引起光谱模型。与冬季climatological流动强迫，CNOP方法识别在给定的起始的限制下面触发最强壮的NAO事件的不安，这被显示出。同时，NAO的阶段力量不对称现象特征能被揭示。由与线性结果作比较，我们发现不安自我相互作用的过程支持否定NAO事件的发作，它比在积极NAO发作期间强壮得多。结果在北方的冬季(DecemberFebruary)用climatological和带平均数的流动独立被获得19792006作为起始的基本状态。我们得出结论，基于NAO发作是一个非线性的起始值的问题的事实，那阶段力量不对称现象是NAO的一个内在的特征。

简介：Themainpathophysiologyofcerebralischemiaisthestructuralalterationintheneurovascularunit,coincidingwithneurovascularmatrixdegradation.Resveratrolhasbeenreportedtobeoneofthemostpotentchemopreventiveagentsthatcaninhibitcellularprocessesassociatedwithischemicstroke.Matrixmetalloproteinases(MMPs)hasbeenconsideredasapotentialdrugtargetforthetreatmentofcerebralischemia.Toexplorethis,wetriedtoinvestigatetheinteractionofresveratrolwithMMPsthroughmoleculardockingstudies.At30minutesbeforeand2hoursaftercerebralischemia/reperfusioninducedbyocclusionofthemiddlecerebralartery,40mg/kgresveratrolwasintraperitoneallyadministered.Afterresveratroladministration,neurologicalfunctionandbrainedemaweresignificantlyalleviated,cerebralinfarctvolumewassignificantlyreduced,andnitriteandmalondialdehydelevelsinthecorticalandstriatalregionsweresignificantlydecreased.ThemoleculardockingstudyofresveratrolandMMPsrevealedthatresveratroloccupiedtheactivesiteofMMP-2andMMP-9.Thebindingenergyofthecomplexeswas–37.848672kJ/moland–36.6345kJ/molforMMP-2andMMP-9,respectively.IncaseofMMP-2,Leu164,Ala165andThr227wereengagedinH-BondingwithresveratrolandincaseofMMP-9,H-bondingwasfoundwithGlu402,Ala417andArg424residues.ThesefindingscollectivelyrevealthatresveratrolexhibitsneuroprotectiveeffectsoncerebralischemiathroughinhibitingMMP-2andMMP-9activity.