简介：Theuniversaily-acceptedrescrvestandardforextra-largescalcgolddepositsis3-5timesmorcthanthatforlargescalegolddeposits(2Ot),namelymoretban6o-lOOt’Assereralextra-largescalegoldde-positshavcbccndiscovercdandmincdinJiaobeiareainl97o’s,tbisarcahasbecomcthemostconcen-tratcdarcafortheoccurrcnccofthjStypcofe

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简介：BackgroundTheconventionalextra-anatomicbypassisoriginatedfromtheaxillary'sarteryandthegraftsizeisoftenlimitedduetothesmalldiameterofaxillary'sartery.Extra-anatomicbypassgraftoriginatingfromascendingaortacanimprovethegraftsizeanddistalperfusion,butneedsternotomywhichmighthavehigheroperativeriskscomparedwithaxillo-femeralbypass.Wesummarizeourexperiencesofextra-anatomicbypassfromascendingaortaforatypicalaorticcoarctation.MethodsBetweenJanuary2005andFebruary2008,5womenagedfrom18to64yearsunderwentextra-anatomicbypassfromascendingaortatoabdominalaortaoriliacarterybypassfortreatmentofatypicalaorticcoarctation.Preoperatively,allpatientshadhypertensionandneededanti-hypertensivemedications.Systolicbloodpressurewas151±9mmHg.Anklepressureindex(API)were0.60±0.23inleftand0.56±0.23inright.Averagesystolicpressuregradientofaorticstenosiswas76±18mmHg.Threepatientsunderwentconcomitantcardiacoperation,includingcoronaryarterybypassgrafting,Bentallprocedureandatrialseptaldefectrepair.ResultsTherewasnohospitalandlatemortalityduring58±15monthsfollow-up(rangefrom44to81months).Postoperativesystolicbloodpressurewasreducedto126±11mmHgatthetimeofdischarge.Allpatientsmaintainednormalbloodpressurewithoutmedicationduringfollow-up.APIwasimprovedto1.12±0.24inleftand1.17±0.25inright(comparedwithpreoperativedata,P<0.05).Follow-upcomputertomographyshowedpatencyinallgrafts.ConclusionsSurgicaltreatmentofatypicalaorticcoarctationwithextra-anatomicbypassoriginatingfromascendingaortaalleviateshypertensionandlowlimbischemia.

简介：<正>Accordingtopressreports,China’sfirstlongdistance,extra-highvoltagecableisexpectedtocrossQiongzhouStraitsbefore2006.

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简介：Canada'sHuskyEnergyInc.hasdiscoveredasignificantdeepwatergasreservewithitsChinesepartner,ChinaNationalOffshoreOilCorp.(CNOOC),intheSouthChinaSeanearHongKong.Basedonpreliminaryanalysisofdrillingresults,thediscoverycouldcontainapotentialrecoverableresourceoffourtosixtrillioncubicfeet(120billionto180billioncubicmeters)ofnaturalgas,theenergycompanysaidinastatement.'WeareverypleasedwithourexplorationresultsandthisdiscoveryconfirmsourconfidenceinthesignificantundiscoveredhydrocarbonpotentialintheSouthChinaSea,'JohnLau,HuskyCEOandpresidentsaid.'WelookforwardtoevaluatingthisdiscoveryandcontinuingourexplorationeffortsinChina.'

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简介：big意为“大”。一般指体积、形态上的大，在修饰人时，指身材的高大或转意为重要人物，它的反义词是little．

简介：Twelveyearsago,EastAsiancooperationstartedduringtheAsianfinancialcrisis.Adozenyearslater,EastAsiancooperationwasupgradedtoanewheightduringamorewidespreadglobalfinancialcrisis.Inrecentyears,regionalcooperationinEastAsiahasunfoldeditsdynamicforceandmadefurtherprogress.The'10(ASEAN)+3(China,JapanandROK)'and'10(ASEAN)+1

简介：Nonceliacglutensensitivity(NCGS)isasyndromecharacterizedbyacohortofsymptomsrelatedtotheingestionofgluten-containingfoodinsubjectswhoarenotaffectedbyceliacdisease(CD)orwheatallergy.Thepossibilityofsystemicmanifestationsinthisconditionhasbeensuggestedbysomereports.Inmostcasestheyarecharacterizedbyvaguesymptomssuchas‘foggymind’,headache,fatigue,jointandmusclepain,legorarmnumbnessevenifmorespecificcomplaintshavebeendescribed.NCGShasanimmune-relatedbackground.IndeedthereisastrongevidencethataselectiveactivationofinnateimmunitymaybethetriggerforNCGSinflammatoryresponse.ThemostcommonlyautoimmunedisordersassociatedtoNCGSareHashimotothyroiditis,dermatitisherpetiformis,psoriasisandrheumatologicdiseases.ThepredominanceofHashimotothyroiditisrepresentsaninterestingfinding,sinceithasbeenindirectlyconfirmedbyanItalianstudy,showingthatautoimmunethyroiddiseaseisariskfactorfortheevolutiontowardsNCGSinagroupofpatientswithminimalduodenalinflammation.Onthesebases,anautoimmunestigmainNCGSisstronglysupported;itcouldbeacharacteristicfeaturethatcouldhelpthediagnosisandbesimultaneouslymanaged.ApossibleneurologicalinvolvementhasbeenunderlinedbyNCGSassociationwithglutenataxia,glutenneuropathyandglutenencephalopathy.NCGSpatientsmayshowevenpsychiatricdiseasessuchasdepression,anxietyandpsychosis.Finally,alinkwithfunctionaldisorders(irritablebowelsyndromeandfibromyalgia)isatopicunderdiscussion.Inconclusion,thenoveltyofthismatterhasgeneratedanexpansionofliteraturedatawiththeunavoidableconsequencethatsomereportsareoftenbasedonlowlevelsofevidence.Therefore,onlystudiesperformedonlargesampleswiththeinclusionofcontrolgroupswillbeabletoclearlyestablishwhetherthelargeinformationfromtheliteratureregardingextra-intestinalNCGSmanifestationscouldbesupportedbyevidence-basedagreements.

简介：Atechniqueofelectronaccelerationinthecone-shapedstationarylaserfieldisproposed.Anelectronaccelerationinthislaserisstudied,whichshowsthatthereisnoelectronbunchingbutthereexistselectroncaptureinthislaserfield.

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简介：Thcrearecloseinnerlinksbetweenthetimeandspatialdistributionsofpolygeneticcompoundlarge/superlargeU-depositsanddiwatectonicinterfaces.ixwatectonicinterfacesaredividedintotwotypes,namely,oneinspaceandtheotherintimc.Thcfollowin8tcctonicintcrfacesallbclongtodiwaspatialtyPc:l)Gcotcctonicunconformityintcr

简介：AbstractBackground:Hematopoietic stem cells (HSCs) have the ability to differentiate into all subsets of blood cells and self-renew. Large tumor suppressor 1 (LATS1) and large tumor suppressor 2 (LATS2) kinases are essential for cell cycle regulation, organism fitness, genome integrity, and cancer prevention. Here, we investigated whether Lats1 and Lats2 are critical for the maintenance of the self-renewal and quiescence capacities of HSCs in mice.Methods:Quantitative reverse transcription-polymerase chain reaction was used to determine the expression levels of Lats1 and Lats2 in subsets of progenitor cells and mature bone marrow cells. A clustered regularly interspaced short palindromic repeats system was used to generate Lats1 or Lats2 knockout mice. Complete blood cell counts were used to compare the absolute number of white blood cells, lymphocytes, monocytes, neutrophils, and platelets between Lats1 or Lats2 heterozygotes and littermates. Flow cytometry was used to assess the size of hematopoietic progenitor cells (HPCs) and HSC pools in Lats1 or Lats2 heterozygotes and littermates. The comparison between the two groups was analyzed using Student’s t test.Results:Lats1 and Lats2 were widely expressed in hematopoietic cells with higher expression levels in primitive hematopoietic cells than in mature cells. Lats1 or Lats2 knockout mice were generated, with the homozygotes showing embryonic lethality. The size of the HPC and HSC pools in Lats1 (HPC: wild-type [WT] vs. heterozygote, 220,426.77 ± 54,384.796 vs. 221,149.4 ± 42,688.29, P = 0.988; HSC: WT vs. heterozygote, 2498.932 ± 347.856 vs. 3249.763 ± 370.412, P = 0.105) or Lats2 (HPC: WT vs. heterozygote, 425,540.52 ± 99,721.86 vs. 467,127.8 ± 89,574.48, P = 0.527; HSC: WT vs. heterozygote, 4760.545 ± 1518.01 vs. 5327.437 ± 873.297, P = 0.502) heterozygotes were not impaired. Moreover, the depletion of Lats1 or Lats2 did not affect the overall survival of the heterozygotes (Lats1: P = 0.654; Lats2: P = 0.152).Conclusion:These results indicate that a single allele of Lats1 or Lats2 may be sufficient for normal hematopoiesis.

简介：七十年以前，Myers和Steenrod证明没有边界歧管的Riemannian的isometry组有谎言组的结构。在2007，Bagaev和Zhukova为Riemannianorbifold证明了一样的结果。在这份报纸，作者首先证明isometryRiemannian组织歧管有边界的M至多有尺寸吗？dimM(dimM？1)。然后有他们的isometry组达到的边界的如此的Riemannianmanifolds前面的最大的尺寸完全被分类。与边界歧管的关键词Riemannian-Isometry-旋转地对称的度量标准-主要轨道2000苏布杰克特先生分类53C99-57S15工程由国家天赋支持了中国的科学基础(Nos.10601053，10671096，10871184，10971104)。

简介：HostedbyMinistryofCultureandGuangzhouMunicipalPeople'sGovernment,GuangzhouBureauofCultureorganizedalistoffirst-classsinginganddancingandacrobaticplaysinGuangzhouinSeptember2006.Amongtheseplays,largeoriginalacrobaticplayPilgrimagetotheWestofGuangzhouAcrobaticTroupewentonthestageduringOctober12thandNovember5th.

简介：Itisachallengingproblemofsurface-baseddeformationtoavoidapparentvolumetricdistortionsaroundlargelydeformedareas.Inthispaper,weproposeanewrigidityconstraintforgradientdomainmeshdeformationtoaddressthisproblem.Intuitivelytheproposedconstraintcanberegardedasseveralsmallcubesdefinedbythemeshverticesthroughmeanvaluecoordinates.Theuserinteractivelyspecifiesthecubesintheregionswhicharepronetovolumetricdistortions,andtherigidityconstraintscouldmakethemeshbehavelikeasolidobjectduringdeformation.Theexperimentalresultsdemonstratethatourconstraintisintuitive,easytouseandveryeffective.

简介：Inthispaper,acomparisonamongthesevenlargemeandersoftheKuroshioismadeinordertoprobeintotheirsimilarityanddifferences.Themajorresultsaredescribedasfollows.1.Althoughthethreephasesforthesevenlargemeanderssuchastheirformations,maturity,aswellasdeclineareverysimilartooneanother,eachmeanderhasitsowntrivialdifferenceindetail.2.Thepathsofthefirstsixlargemeandersinthematurephasemaybeclassifiedintotentypes:U1,V1,U2,V2,U1’,V1’,U2’,V2’,φandW.3.Thesevenlargemeandersmaybegroupedintotwopatterns,i.e.,patternⅠandpatternⅡ.PatternⅠincludesthefirstandthefourthlargemeanders,andpatternⅡincludestherestoftheabovemeanders.4.FourstandardsforidentifyingthelargemeandersoftheKuroshioareputforward.

简介：SYPHILIS1SCHARACTERIZEDbyseveralclinicalstages:primary,secondary,latentandtertiary.Duetothevarietyoflesionsthatmaypresentduringthesecondstage,syphilishasitsreputationofbeingthe"greatimpostor."Therefore,delaysinitsdiagnosisandtreatmentarecommonlyreported.

简介：Sequentialsimulationoflargecomplexphysicalsystemsisoftenregardedasacomputationallyexpensivetask.Inordertospeed-upcomplexdiscrete-eventsimulations,theparadigmofParallelandDistributedDiscreteEventSimulation(PDES)hasbeenintroducedsincethelate70s.Inthispaperwe'llanalyzetheapplicabilityofPDEStothemodelingandanalysisoflargecomputersystem;suchsystemsareincreasinglycommonintheareaofHighEnergyandNuclearPhysics,becausemanymodernexperimentsmakeuseoflarge"computefarms",Somefeasibilitytestshavebeenperformedonaprototypedistributedsiumulator.