简介：AbstractAutoimmune diseases with hematological manifestations are often characterized by chronicity and relapses despite treatment, and the underlying pathogenetic mechanisms remain unknown. Epigenetic alterations play a vital role in the deregulation of immune tolerance and the development of autoimmune diseases. In recent years, study of epigenetic mechanisms in both adult and childhood autoimmune disorders has been seeking to explain the pathophysiology of these heterogeneous diseases and to elucidate the interaction between genetic and environmental factors. Various mechanisms, including DNA methylation, histone modifications (chromatin remodeling), and noncoding RNAs (ncRNAs), have been studied extensively in the context of autoimmune diseases. This paper summarizes the epigenetic patterns in some of the most common childhood autoimmune disorders with hematological manifestations, based on epigenetic studies in children with primary immune thrombocytopenia (ITP), systemic lupus erythematosus (SLE), and juvenile idiopathic arthritis (JIA). Research findings indicate that methylation changes in genes expressed on T cells, modifications at a variety of histone sites, and alterations in the expression of several ncRNAs are involved in the pathogenesis of these diseases. These mechanisms not only determine the development of these diseases but also affect the severity of the clinical presentation and biochemical markers. Further studies will provide new tools for the prevention and diagnosis of childhood autoimmune disorders, and possible novel treatment options.

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简介：在hematological上调查Ipomoeacarnea花的乙醇摘录的活跃氯仿部分的目的在Wistar老鼠在甲苯改变导致diisocyanate的发炎。方法除了控制组，，所有用10%甲苯diisocyanate(TDI)的5L的intranasal申请老鼠被敏化7天。在第二促进感受性以后的一个星期，所有与5%TDI的5L老鼠被挑起导致航线超敏性。在最后挑战以后，血和bronchoalvelorlavage(BAL)液体镇定、使遭到总计，微分白细胞数。闪光层析在最活跃的氯仿部分上被执行孤立一个单个部件。有在200mg摥琠敨洠獯?汰畡楳汢?潳牵散漠?畨慭?湩敦瑣潩?的口头的剂量的ethanolic摘录和它的氯仿部分的结果处理??桴?慳敭瀠牥潩?挠獡獥漠?L牯楴湯挠畡敳?祢??畢湲瑥楩眠牥?潣普物敭?瑡琠潷搠楡祲猠敨灥映牡獭?匊湩散㈠??愠氠牡敧洠汵楴楤'諡箻H慮祲爠獥慥捲?潰瑲潦楬?慨?瑳牡整?愠浩摥愠?敧敮慲楴杮戠瑥整?湫睯敬杤?L畯?桴獩搠獩慥敳?湉?湵?????敦敶?湩猠慭汬爠浵湩湡獴欠灥?潦?業歬瀠潲畤瑣潩?敢慣敭渠瑯晩慩汢?湩琠敨丠瑥敨汲湡獤映牯映牡獭眠瑩?湡愠潢瑲潩?慲整漠?潭敲琠慨?楦敶瀠牥挠湥???桴?畡畴湭漠

简介：AbstractIntroduction:Celiac disease typically presents with symptoms of malabsorption, but extraintestinal manifestations are increasingly reported. Aplastic anemia as the mode of celiac disease presentation is extremely rare in children.Case presentation:We report a 2-year-old boy who presented with loose stools, loss of appetite, and bicytopenia with severe aregenerative normocytic anemia. Investigations, including bone marrow aspirate and biopsy, revealed aplastic anemia. Screening for malabsorption showed increased plasma concentrations of anti-transglutaminase and anti-gliadin antibodies. A duodenal biopsy confirmed the histologic features of celiac disease. The child received a packed red cell transfusion and was started on a gluten-free diet, with a very good prognosis and normalization of both his blood and histological parameters. To the best of our knowledge, our report is the sixth pediatric case in the literature.Conclusion:Screening for celiac disease should be performed in children with unexplained hematological abnormalities such as aplastic anemia with or without gastrointestinal symptoms.