简介：Ancientpeoplesfromaroundtheworldknewaboutthespecialrelationshipbetweenacircle'scircumferenceanditsdiameter.π,thenumberrepresentingtheresultwhenacircle'scircumferenceisdividedbyitsdiameter,hadbeenknownandusedonproblemsforthousandsofyears.Consequently,inordertocalculatetheareaofacircle,πisalsoused,area=πr2.

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简介：Thephotovoltaicbehavioursofthinfilmsofnovelphotosensitizerconsistingofcova-lentlylinkedphthalocyanine（Pc）andanthraquinone（AQ）werestudiedin0.1mol/LNa2SO4solu-tion.Theresultsrevealedthatthehigherphotovoltageandphotocurrenthavebeenobtainedduetolightinducedintra-moleculesfastelectrontransferinlinkedPc-AQcompounds.TheeffectsofdifferentspacerchainsbetweenPcandAQmoleculesonphotovoltaicbehaviourswerealsodiscussed.

简介：便携式音乐播放器确实可以使我们享受美妙的音乐，但耳朵却要为此付出相当大的代价……

简介：最新的一项研究表明那些乘坐交通工具上下班的人们，无论是自驾车，骑自行车还是坐公交车，他们在乘坐交通工具一个小时后患心脏病的几率提高了两倍。科学家们对此做出了不同的解释。

简介：如果说企业成功有方程式，那就是优异的产品、优异的商业模式和优异的企业文化。立足职场白领的领英，正是凭借这三板斧在社交网络占据了重要的一席之地，并立志高远，打造人力资源终极平台。2014年年底，全球最大的职场白领社交网站领英（Linkedin，LNKD，NYSE）斥资近2亿美元收购B2B市场营销的领袖企业Bizo。后者通过高水准的数据分析，帮助客户对商业用户进行精准定位和营销。

简介：客观:cross-linked生产，它被准备由哈并且cross-linking代理人STMP，EDC，通过cross-linking反应的GP，可能在药交货系统(DDS)被使用。保证临床的申请的安全，优秀性质象没有房间毒性那样，nonirritant，没有将军毒性，没有免疫学的拒绝是必要的。方法:根据GB/T的请求，16886.1在医药biomaterials，房间毒性测试，溶血测试，intracutaneous刺激测试，尖锐毒性测试，和过分敏感的测试的安全评估上被要求。结果：HA-STMP的房间毒性，HA-EDC，HA-GP都是不到1。所有过分敏感的测试是合格的。但是HA-EDC，忽视的生产的不同的度激动的HA-GP，细微毒性，溶血率，它比标准价值大。结论:HA-STMP拥有赞成biocompatibility，它是一种理想的biomaterials和药搬运人。

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简介：Emulsifier-freeemulsionpolymerizationofstyreneinthepresenceofβ-hydroxypropylacrylatewasstudied.Theemulsifier-freeselfcrosslinkedpolystyrenelatexmicrosphereswasobtained.Monomerconversionishigherthan90%when[St],[β-HPA],[KPS]is2.66,0.228,and5.8×10^-3mol/Lrespectivelyunder80℃for5h.Themono-dispersedlatexparticlediameterandcolloidalparticleconcentrationweregivenasD=0.23um,N=3.13×10^13/cm^3byTEManalyse,Thefactorsofinfluencinglatexstabilitywerediscussed.ThecopolymerwascharacterizedbyIRanddissolutionexperiment.Theapparentactivationenergyofpolymerizationandpolymerizationrateconstantwereobtainedtobe78.7KJ/moland514.4/mol.srespectively.

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简介：Analysisofthefrequencyofantigen-specificcytotoxicTlymphocytes(CTLs)exvivoislargelydependentontheuseofMHC/peptidetetramers.However,thelatterreagentshavenotbeenwidelyavailable,mostlikelybecauseoftheircostlyandtime-consumingproduction.InthisreportweutilizedaneconomicstrategytoconstructHLA/peptidetetramerswithrecombinantpeptide-linkedβ2microglobulin(β2m).TheHLA-A2-restricted,melanomaantigenMARTl-derivedpeptideMARTI27-35(AAGIGILTV)wasfusedtotheNterminusofhumanβ2mthrougha15-aminoacid(aa)-longlinkerbeforebeingrefoldedwiththerecombinantbiotinylatedHLA-A2heavychainectodomain.Theresulted2-component(2C)monomerwasthentetramerizedwithphycoerythin-labeledstreptavidin.Theexperimentalresultshowedthatthe2CHLA-A2/MARTI27-35monomerwasshowntobindtotheHLAclassⅠcomplex-specificmonoclonalantibodyW6/32andtheHLA-A2/MARTI27-35complex-specificsinglechainantibodyfragment(scFv)8.3,suggestingthecorrectnessofitsspecificity.Furthermore,the2CHLA-A2/MARTI27-35tetramerdetectedaspecificCD8^+TcellpopulationinHLA-A2-restrictedmelanomainfiltratinglymphocytesastheconventional3CHLA-A2/MARTI27-35tetramer.Theyieldof2CHLA-A2/MARTI27-35monomerwas2.5timesmorethanthatoftheconventional3Cmonomer.Takentogether,thesedataindicatethattheHLA-A2/MARTI27-35tetramercanbegeneratedconvenientlythroughtheuseofMARTI27-35peptide-β2mfusionproteins,whichcanfacilitatethemonitoringofHLA-A2-restricted,MARTl-specificCTLresponsesinpatientswithmelanoma.

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简介：客观:在乙醇的媒介(非极)，是的STMP和ADH，以由没有一个胶化阶段，得到稳定的cross-linked产品准备药交货microspheres，并且学习cross-linked产品的biocompatibility和biodegradability的crosslinkers哈。方法:是的生物医学的材料的ISO10993.1安全评估一本参考书，做溶血测试，经皮的刺激测试，vitro降级测试，和降级产品的尖锐毒性测试，和分析。结果:HA-STMPcross-linked产品没把溶血，没有激怒，没有尖锐全身的毒性，而是HA-ADH有温和皮肤激怒和不利尖锐全身的毒性。HA-STMPcross-linked产品HAse和曲线上的有的更低的敏感是flatting。随HA-STMP结果被结构分析改变的降级时间的增加，这些房间的降级产品不是毒性。结论:有到水解作用的更好的biocompatibility和更好的抵抗的HA-STMPcross-linked产品能推迟降级时间，它对可被细菌破坏的药搬运人的准备合适。

简介：ObjectivesPhenotypicoverlapofBrugadasyndromewithtype3longQTsyndromeisobservedinsomecarriersofmutationsintheNachannelSCN5A.Concomitant-Brugadasyndromeand3typelongQTsyndromeassociatedwithsodiumchannelmutationwasreportedbefore,however,nodatashowedconcomitant-BrugadatypeandshortQTintervalelectrocardiogram(ECG)andrevealedtheassociated-genemutation.MethodsThedirectDNAsequencewasconducedtofindthemutation.Themutationwasreproducedinvitrousingsite-directedmutagenesisandcharacterizedusingthepatchclamptechniqueinthewhole-cellconfiguration.ResultsThepatientwiththefamilyhistoryofsuddendeathshowedBrugadaandshortQTintervalECG.SequenceofSCN5Aidentifiedamissensemutation,R689H,previouslyassociatedwithalongQTsyndrome.BiophysicalstudyshowedthattheR689Hfailedtogenerateanycurrentwhenheterolo-gouslyexpressedinHEKcells.ConclusionsOurfindingsindicateforthefirsttimethatcoexisted-BrugadatypeandshortQTintervalECGlinkedtothelossoffunctioninSCN5Amutation.

简介：Aseriesofbiodegradablehydrogelsbasedondextranandpoly(L-glutamicacid)werefabricatedforeffectivevancomycinloadingandrelease.Thepreparationofhydrogelswassimplyachievedbyphotocross-linkingofmethacrylateddextranandpoly(L-glutamicacid)-g-hydroxyethylmethacrylate(PGH)inthepresenceofphotoinitiatorI2959.ThestructuresofhydrogelswerecharacterizedbyFTIRandSEM.Theswellingandenzymaticdegradationbehaviorsofhydrogelswereexaminedtobedependentonthepoly(L-glutamicacid)contentinthehydrogels.Thehighercontentofpoly(L-glutamicacid)inthegel,thehigherswellingratioandquickerdegradationwereobserved.Moreinterestingly,thehydrogelwithhigherPGHratioshowedhighervancomycin(VCM)loadingcontent,whichmightbeduetotheelectrostaticinteractionbetweencarboxylategroupsinhydrogelandammoniumgroupofVCM.InvitrodrugreleasefromtheVCM-loadedhydrogelsinaqueoussolutionexhibitedsustainedreleaseofVCMupto72h,whiletheinvitroantibacterialtestbasedontheVCM-loadedhydrogelshowedanefficientMethicillin-ResistantS.aureus(MRSA)inhibitionextendingoutto7days.Theseresultsdemonstratedthatthebiodegradablehydrogelswhichformedbyinsituphoto-crosslinkingwouldbepromisingasscaffoldsorcoatingsforlocalantibacterialdrugreleaseintissueengineering.

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简介：Afterprimaryanalysesontheserumglycocon-jugatesoflungcancerandnormalindividulusingtheenzyme-linkedlectinassay(ELLA)with12kindsoflectins,PHAandLCAwereselectedtofurtherstudyintheseraof8kindsofcancers,4kindsofnon-malignantdiseaseand1kindofpostoperativecancer.Itwasfoundthatthetestvaluesof7kindsofcancerswithPHAorLCAweresignificantlyhigherthanthatofthenormal(P<0.01);thevaluesof4kindsofnon-malignantdiseaseswithPHAwerenothigher(P>0.05);thevaluesofthepostoperativecancerwithPHAwereobviouslylowerthanthatofthepreoperative(P<0.05).TheresultsshowedthattheserumglycoconjugateswhichcanbindtoPHAseemedrelatedtothecancerousexistenceinhumanbodies.Thesignificanceofthefindingswasdiscussed.

简介：Insearchofasuitableadsorbentusedfortheenrichmentandseparationofnaturalsaponinsfromanaqueoussolution,aseriesofporouscross-linkedpoly(vinylaceto-phenone)resinsI-ⅨweresynthesizedviatheFriedel-Craftsacylationofstyrene-divinyl-benzenecopolymerbeads.Theircarbonylcontentswerecharacterizedbyinfraredspectraandelementalanalysis.Theirphysicalpropertiessuchasbulkdensities,skeletondensities,andspecificsurfaceareaswerealsodetermined.Thetestsfortheresinsadsorptionofgypenosidesshowedthatonlythoseresinswithhighcarbonylcontentsandlargespecificsurfaceareascouldfavorablyadsorbgypenosidesfromanaqueoussolutionwithmuchhighercapacities.

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