简介：BackgroundThisarticlesummarizedtheexperienceofatrioventricularvalvereplacementoperationforfunctionalsingleventriclepatientswhoseatrioventricularvalvewasinsufficiency.Thefollow-uptimeofoperationwasarrangedfromearly-tomedium-term.MethodsFromJuly2009toJuly2015,therewere40patientsoffunctionalsingleventriclereceivingtheoperationofatrioventricularvalvereplacement,including23maleand17femalepatients.TheageatA-Vvalvereplacementwasrangedfrom6daysto32years(themediumageof9years),andthebodyweightrangedfrom2.7to57kg(themediumbodyweightof21.5kg).Moreover,theatrioventricularvalvereplacementwasperformedonallpatientsunderextracorporealcirculation.ResultsAtrioventricularvalvereplacementwasperformedon40patientswithfunctionsingleventricleinhospital,ofwhicheight(20.0%)diedinhospitalincludingtwoneonateandinfant(agerange:6days-2yearsold)accountingfor25%(2/8),Amongthem,sevenpatientsdiedoflowcardiacoutputsyndrometwopatientswithrepeatedhypoxemiaconcurrentinfectionafteroperation,andonewithbilateraldiaphragmaticparalysisandmalignantarrhythmia.Forthepatientssufferingthesevereperivalvularleakage,therewasareoperation,andthecardiacfunctionbeforethefirstoperationwasclassⅣ.OnepatientreceivedhearttransplantationfinallyforsevereheartfailureafterAVvalvereplacement.Fortherestofpatients,theircardiacfunctionrecoveredtoclassⅠ-Ⅱafteroperation.ConclusionsForfunctionsingleventriclepatientswithatrioventricularvalveregurgitation,themortalityrateofatrioventricularvalvereplacementcanbeacceptediftheoperationwasindicated.Forpatientswithsevereatrioventricularvalueregurgitation,theresultoftheoperationintheearlyandmediumtermwassatisfying.Thus,theatrioventricularvalvereplacementservedasausefultreatmentforpatientsdiagnosedofA-Vvalveregurgitationandfunctionalsingleventricle.

简介：Objective:Implantableportthrombosis(IPT)incancerpatientsisarelativelyrarebutseverecomplication.Severalfactorsarereportedlyassociatedwiththeoccurrenceofthrombosis.WeaimedtodescribetheprevalenceandtheanatomoclinicalfeaturesofIPTobservedincancerpatientswhoweretreatedinamedicaloncologydepartmentinTunisia.Methods:Atotalof600cancerpatientswhohadportimplantationfromJanuary2013toDecember2015wereretrospectivelyidentified.Caseswithsymptomatic/incidentalIPT(radiologicallyconfirmed)werefurtheridentified.Epidemiologicalandanatomoclinicalfeatureswerecollectedfrompatientrecordsandthedepartmentdatabase.Results:Weobservedthat33ofthe600patientshadIPT;thus,theprevalencewas5.5%.Themedianagewas57years,andthegenderratiowas0.43.Overweightorobesitywasobservedin73%ofthepatients.IPToccurredmainlyinpatientswithbreast(36.4%)andcolorectal(33.3%)cancers,whichweremostlynonmetastatic(79%).Atleastoneidentifiedclassicalthromboembolicriskfactorwasfoundin13patients(smokingin9,tamoxifenin2).IPTwassymptomaticin93%ofthecases,occurringwithinanaveragetimeof56days.Implantableportswereremovedbecauseofinfectionin2casesandnonfunctionalityin3cases.IPTtreatmentwasbasedonlow-molecular-weightheparins(94%)andantivitaminK(6%)foranaverageof130days.Fourpatientshadpost-therapycomplications:onethrombosisrecurrenceandthreeinfections.Conclusions:IPTcasesinthe600patientswereobservedtooccurinobesenonmetastaticcancerpatientswithinthefirst3monthsafterIPimplantation.

简介：Splanchniccirculationistheprimarymechanismthatregulatesvolumesofcirculatingbloodandsystemicbloodpressureinpatientswithcirrhosisaccompaniedbyportalhypertension.Recently,interesthasbeenexpressedinmodulatingsplanchniccirculationinpatientswithlivercirrhosis,becausethiscapabilitymightproducebeneficialeffectsincirrhoticpatientsundergoingalivertransplant.Pharmacologicmodulationofsplanchniccirculationbyuseofvasoconstrictorsmightminimizevenouscongestion,replenishcentralbloodflow,andthusoptimizemanagementofbloodvolumeduringalivertransplantoperation.Moreover,splanchnicmodulationminimizesanyhighportalbloodflowthatmayoccurfollowingliverresectionandthesubsequentlivertransplant.Thiseffectissignificant,becausehighportalflowimpairsliverregeneration,andthusadverselyaffectsthepostoperativerecoveryofatransplantpatient.Anincreaseinportalbloodflowcanbeminimizedbyeithersurgicalmethods（e.g.,splenicarteryligation,splenectomyorportocavalshunting）oradministrationofsplanchnicvasoconstrictordrugssuchasVasopressinorterlipressin.Finally,modulationofsplanchniccirculationcanhelpmaintainperioperativerenalfunction.Splanchnicvasoconstrictorssuchasterlipressinmayhelpprotectagainstacutekidneyinjuryinpatientsundergoinglivertransplantationbyreducingportalpressureandtheseverityofahyperdynamicstate.Theseeffectsareespeciallyimportantinpatientswhoreceiveatoosmallforsizegraft.TerlipressinselectivelystimulatesV1receptors,andthuscausesarteriolarvasoconstrictioninthesplanchnicregion,withaconsequentshiftofbloodfromsplanchnictosystemiccirculation.Asaresult,terlipressinenhancesrenalperfusionbyincreasingbotheffectivebloodvolumeandmeanarterialpressure.

简介：Profoundsensorineuralhearingloss(PSHL)isnotuncommonlyencounteredinotology.Inclinics,thereisahighincidenceofotolithicdamageinpatientswithPSHL,butrelevantreportsarefew.Sharingacontinuousmembranousstructureandsimilarreceptorcellultrastructures,thecochleaandvestibulemaybesusceptibletothesameharmfulfactors.Disordersoftheinnerearmayresultinavarietyofmanifestations,includingvertigo,spatialdisorientation,blurredvision,impairedarticulation,andhearingimpairment.ConsideringthediversityofclinicalsymptomsassociatedwithPSHLwithotolithicdysfunction,itmaybefrequentlymisdiagnosed,andobjectivemeansoftestingthefunctionofotolithicorgansshouldberecommendedforhearing-impairedpatients.Vestibular-evokedmyogenicpotentials(VEMPs)viaair-conductedsoundareofgreatimportanceforthediagnosisofotolithicfunction.HearingdevicessuchascochlearimplantsarecommonlyacceptedtreatmentsforPSHL,andearlyidentificationandtreatmentofvestibulardisordersmayincreasethesuccessrateofcochlearimplantation.Therefore,itisnecessarytoincreaseawarenessofotolithicfunctionalstatesinpatientswithPSHL.

简介：Thefibroblastgrowthfactorreceptor(FGFR)familyplaysimportantrolesinregulatingcellgrowth,proliferation,survival,differentiationandangiogenesis.DeregulationoftheFGF/FGFRsignalingpathwayhasbeenassociatedwithmultipledevelopmentsyndromesandcancers,andthustherapeuticstrategiestargetingFGFsandFGFRinhumancancerarecurrentlybeingexplored.However,fewstudiesontheFGF/FGFRpathwayhavebeenconductedinsarcoma,whichhasapooroutcomewithtraditionaltreatmentssuchassurgery,chemotherapy,andradiotherapy.Hence,inthepresentreview,weprovideanoverviewoftheroleoftheFGF/FGFRpathwaysignalinsarcomaandFGFRinhibitors,whichmightbenewtargetsforthetreatmentofsarcomasaccordingtorecentresearch.

简介：AIM:ToinvestigateFusobacteriumnucleatum（F.nucleatum）abundanceincolorectalcancer（CRC）tissuesanditsassociationwithCRCinvasivenessinChinesepatients.METHODS:Theresectedcancerandadjacentnormaltissues（10cmbeyondcancermargins）from101consecutivepatientswithCRCwerecollected.Fluorescentquantitativepolymerasechainreaction（FQ-PCR）wasappliedtodetectF.nucleatuminCRCandnormaltissues.ThedifferenceofF.nucleatumabundancebetweencancerandnormaltissuesandtherelationshipofF.nucleatumabundancewithclinicalvariableswereevaluated.Fluorescenceinsituhybridization（FISH）analysiswasperformedon22CRCtissueswiththehighestF.nucleatumabundancebyFQ-PCRtestingtoconfirmFQ-PCRresults.RESULTS:ThemedianabundanceofF.nucleatuminCRCtissues[0.242（0.178-0.276）]wassignificantlyhigherthanthatinnormalcontrols[0.050（0.023-0.067）]（P<0.001）.F.nucleatumwasover-representedin88/101（87.1%）CRCsamples.TheabundanceofF.nucleatumdeterminedby2-ΔCTwassignificantlygreaterintumorsamples[0.242（0.178,0.276）]thaninnormalcontrols[0.050（0.023,0.067）]（P<0.001）.Thefrequencyofpatientswithlymphnodemetastaseswashigherintheover-abundancegroup[52/88（59.1%）]thanintheunder-abundancegroup[0/13（0%）]（P<0.005）.NosignificantassociationofF.nucleatumwithotherclinico-pathologicalvariableswasobserved（P>0.05）.FISHanalysisalsofoundmoreF.nucleatuminCRCthaninnormaltissues(mediannumber6,25th3,75th10vs2,25th1,75th5)（P<0.01）.CONCLUSION:F.nucleatumwasenrichedinCRCtissuesandassociatedwithCRCdevelopmentandmetastasis.

简介：Objective:Survivalandtreatmentofpatientswithmicroinvasivebreastcancer(MIBC)remaincontroversial.Inthispaper,weevaluatedwhetheradjuvantchemotherapyisnecessaryforpatientswithMIBCtoidentifyriskfactorsinfluencingitsprognosisanddecidetheindicationforadjuvantchemotherapy.Methods:Inthisretrospectivestudy,108patientswithMIBCwererecruitedaccordingtoseventheditionofthestagingmanualoftheAmericanJointCommitteeonCancer(AJCC).Thesubjectsweredividedintochemotherapyandnon-chemotherapygroups.Wecomparedthe5-yeardisease-freesurvival(DFS)andoverallsurvival(OS)ratesbetweengroups.Furthermore,weanalyzedthefactorsrelatedtoprognosisforpatientswithMIBCusingunivariateandmultivariateanalyses.Wealsoevaluatedtheimpactofadjuvantchemotherapyontheprognosticfactorsbysubgroupanalysisaftermedianfollow-uptimeof33months(13-104months).Results:The5-yearDFSandOSratesforthechemotherapygroupwere93.7%and97.5%,whereasthoseforthenonchemotherapygroupwere89.7%and100%.Resultsindicatethat5-yearDFSwassuperior,butOSwasinferior,intheformergroupcomparedwiththelattergroup.However,nostatisticalsignificancewasobservedinthe5-yearDFS(P=0.223)orOS(P=0.530)rateofthetwogroups.Mostrelevantpoor-prognosticfactorswereKi-67overexpressionandnegativehormonalreceptors.Cumulativesurvivalwas98.2%vs.86.5%betweenlowKi-67(≤20%)andhighKi-67(>20%).ThehazardratioofpatientswithhighKi-67was16.585[95%confidenceinterval(CI),1.969-139.724;P=0.010].Meanwhile,ER(-)/PR(-)patientswithMIBChadcumulativesurvivalof79.3%comparedwith97.5%forER(+)orPR(+)patientswithMIBC.ThehazardratioforER(-)/PR(-)patientswithMIBCwas19.149(95%CI,3.702-99.057;P<0.001).SubgroupanalysisshowedthatchemotherapycouldimprovetheoutcomesofER(-)/PR(-)patients(P=0.014),butnotthosewhooverexpressKi-67(P=0.105).Conclusions:PatientswithMIBCwhooverexpressKi-67and

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简介：AIM:Toevaluateshort-termoutcomesfollowingintraoperativebiliarylavageforhepatolithiasis.METHODS:Atotalof932patientswhowereadmittedtotheWestChinaMedicalCenterofSichuanUniversitybetweenJanuary2010andJanuary2014andunderwentbileductexplorationandlithotomywereretrospectivelyincludedinourstudy.Thepatientsweredividedintothelavagegroupandthecontrolgroup.Relatedpre-,intra-,andpostoperativefactorswererecorded,analyzed,andcomparedbetweenthetwogroupsinordertoverifytheeffectsofbiliarylavageontheshort-termoutcomeofpatientswithhepatolithiasis.RESULTS:Amongstthepatientswhowereincluded,678patientswithhepatolithiasiswereincludedinthelavagegroup,andtheother254patientswereenrolledinthecontrolgroup.Dataanalysesrevealedthatpreoperativebaselineandrelatedintraoperativevariableswerenotsignificantlydifferent.However,patientswhounderwentintraoperativebiliarylavagehadprolongedpostoperativehospitalstays(6.67dvs7.82d,P=0.024),higherhospitalizationfees(RMB28437.1vsRMB32264.2,P=0.043),higherpositiveratesofbacterialculturesfromblood(13.3%vs25.8%,P=0.001)andbile(23.6%vs40.7%,P=0.001)samples,andincreasedusageofadvancedantibiotics(26.3%vs38.2%,P=0.001).Inaddition,inthelavagegroup,morepatientshadfever(>37.5℃,81.4%vs91.1%,P=0.001)andhyperthermia(>38.5℃,39.7%vs54.9%,P=0.001),andhigherwhitebloodcellcountswithin7daftertheoperationcomparedtothecontrolgroup.CONCLUSION:Intraoperativebiliarylavagemightincreasetheriskofpostoperativeinfection,whilenotsignificantlyincreasinggallstoneremovalrate.

简介：Whenmanyolder(seasoned)physicianstrained,moderncardiovascularimaginge.g.cardiacultrasound,nuclearstudies,computedtomography,cardiacMRdidnotexist.Non-invasiveimagingstudiesthatwereavailabletousincludedtheECG,stressexercisetesting,andchestX-ray.Invasivestudiessuchashemodynamicsandangiographyweretheonlyphysiologicandanatomicstudiesavailable.Thustherewereveryfewimagingstudiesusedforclinicaldecisionmakingtoconfirmthediagnosis,estimateprognosis,orplantherapyofthecardiaccondition.Thebestofthesewascardiaccatheterizationwithventricularandcoronaryangiographyinadultpatientsandmeasurementofintracardiacpressure,oximetryandangiographyinpatientswithcongenitalheartdisease.Thisisstillthecasein2016withmanymoreimagesadded.

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简介：AIM:Toevaluategutmicrobialdysbiosisintwovisceralhypersensitivemodelsincomparisonwithirritablebowelsyndrome(IBS)patientsandtoexploretheextenttowhichthesemodelscapturethedysbiosisofIBSpatients.METHODS:Visceralhypersensitivitywasdevelopedusingthematernalseparation(MS)ratmodelandpost-inflammatoryratmodel.Thevisceralsensitivityofthemodelgroupsandcontrolgroupwasevaluatedusingtheabdominalwithdrawreflexscoreandelectromyographyinresponsetogradedcolorectaldistention.The16SribosomalRNAgenefromfecalsampleswaspyrosequencedandanalyzed.Thecorrelationbetweendysbiosisinthemicrobiotaandvisceralhypersensitivitywascalculated.PositivefindingswerecomparedtosequencingdatafromapublishedhumanIBScohort.RESULTS:Dysbiosistriggeredbyneonatalmaternalseparationwaslastingbutnotstatic.BothMSandpostinflammatoryratfecalmicrobiotadeviatedfromthatofthecontrolratstoanextentthatwaslargerthantheco-housingeffect.Twoshortchainfattyacidproducinggenera,FusobacteriumandClostridiumXI,weresharedbythehumanIBScohortandbythematernalseparationratsandpost-inflammatoryrats,respectively,todifferentextents.FusobacteriumwassignificantlyincreasedintheMSgroup,anditsabundancepositivelycorrelatedwiththedegreeofvisceralhypersensitivity.Porphyromonadaceaewasaprotectivebiomarkerforboththeratcontrolgroupandhealthyhumancontrols.CONCLUSION:ThedysbiosisMSratmodelandthepost-inflammatoryratmodelcapturedsomeofthedysbiosisfeaturesofIBSpatients.Fusobacterium,ClostridiumXIandPorphyromonadaceaewereidentifiedastargetsforfuturemechanisticresearch.

简介：Objective:Thepredictiveandprognosticroleofprognosticnutritionalindex(PNI)ingastriccancerpatientswithperitonealdisseminationremainsunclear.ThisstudyaimstoexploretheroleofthePNIinpredictingoutcomesofgastriccancerpatientswithperitonealdissemination.Methods:Atotalof660patientsdiagnosedwithgastricadenocarcinomawithperitonealmetastasisbetweenJanuary2000andApril2014atSunYat-senUniversityCancerCenterandtheSixthAffiliatedHospitalofSunYatsenUniversitywereretrospectivelyanalyzed.Theclinicopathologiccharacteristicsandclinicaloutcomesofpatientswithperitonealdisseminationwereanalyzed.Results:ComparedwithPNI-highgroup,PNI-lowgroupwascorrelatedwithadvancedage(P=0.036),worseperformancestatus(P<0.001),higherfrequencyofascites(P<0.001)andhigherfrequencyofmultisitedistantmetastasis(P<0.001).Kaplan-MeiersurvivalcurvesshowedthatPNI-highgrouphadasignificantlylongermedianoverallsurvivalthanPNI-lowgroup(13.13vs.9.03months,P<0.001).MultivariatesurvivalanalysisrevealedthatBorrmanntypeIV(P=0.014),presenceofascites(P=0.017)andlowerPNI(P=0.041)wereindependentpoorprognosticfactors,andpalliativesurgery(P<0.001)andfirst-linechemotherapy(P<0.001)weregoodprognosticfactors.Forpatientsreceivingpalliativesurgery,thepostoperativemorbidityratesinthePNI-lowgroupandPNIhighgroupwere9.1%and9.9%,respectively(P=0.797).ThepostoperativemortalityratewasnotsignificantlydifferentbetweenPNI-lowandPNI-highgroups(2.3%vs.0.9%,P=0.362).Conclusions:PNIisausefulandpracticaltoolforevaluatingthenutritionalstatusofgastriccancerpatientswithperitonealdissemination,andisanindependentprognosticfactorforthesepatients.

简介：Managingmicrotiapatientsisalwaysachallenge.Multidisciplinaryapproach,goodfamilysupport,wellestablisheddoctorepatientrelationshipandwellorganisedpatient-supportgroupsaretheessentialelementsforsuccess.Withtheadvancementofimplantablehearingdevices,moreoptionswillbeavailableforthemicrotiapatients.Otologistsplayaleadingroleinthewholemanagementprocess.Theynotonlyprovideproperguidancetothepatientsinchoosingthecorrectpathofthetreatment,butalsoplayakeyroleinorganisingandmaintainingacosteffectivemultidisciplinaryrehabilitationteamforthemicrotiapatients.

简介：Objective:Toassessthecardiovascularabnormalitiesinpatientswithspontaneoussubarachnoidhemorrhage(SAH).Methods:AllpatientsadmittedtoourinstitutionwithaprimarydiagnosisofspontaneousSAHandhadatransthoracicechocardiogram(TTE)performedfrom1stofJuly2011until30thofMay2014wereenrolled.Results:Outof2058patientsadmittedtoourinstitutionwithadiagnosisofSAH,overathreeyearperiod,only244patients(12%)hadTTEperformedduringtheindexhospitalization.Inthisselectedcohort,themeanagewas59yearsand66%ofpatientswerefemale.ElevatedtroponinTwasnoticedin37%ofpatientsandQTcprolongationwasthecommonestECGabnormalityoccurringin49%ofthepatients.Thirtyninepatients(16%)hadarestingsegmentalwallmotionabnormalityontheTTE,includingfivepatientswithapicalballooning.In-hospitalmortalitywas15.6%(38patients).Conclusion:CardiovascularabnormalitiesinselectedpatientswithSAHwhohadcardiacultrasoundarerelativelycommon;howevertheincidenceofventricularballooningislow.InordertoattainthecorrectincidenceofcardiovascularabnormalitiesinSAHpatients,allpatientsadmittedwithSAHshouldundergoTTEandhaveECGandcardiacmarkerscheckedduringtheirhospitalization.

简介：AIM:Toinvestigatetheprevalenceandriskfactorsofdiabeticretinopathy(DR)innorthernChinesepatientswithtype2diabetesmellitus(T2DM).METHODS:Thisretrospectivecross-sectionalstudywasperformedbetweenMay2011andApril2012.Atotalof1100patients(male/female,483/617)wereincludedinthisstudy.DRwasdefinedfollowingtheEarlyTreatmentDiabeticRetinopathyStudy(ETDRS)severityscale.Allincludedpatientsacceptedacomprehensiveophthalmicexaminationincludingretinalphotographs.Logisticregressionmodelswereusedtoestimateoddsratios(ORs)and95%confidenceinterval(CI)afteradjustingforageandgender.RESULTS:Retinopathywaspresentin307patientswithaprevalenceof27.9%.Inunivariatelogisticanalysis,presenceofDRwasassociatedwithlongerdurationofdiabetes(OR,5.70;95%CI,2.91-12.56),higherconcentrationoffastingbloodglucose(OR,12.94;95%CI,2.40-67.71),higherlevelofglycosylatedhemoglobinHbA1c(OR,5.50;95%CI,3.78-11.97)andinsulintreatment(OR,6.99;95%CI,1.39-35.12).ThelifestyleofpatientswithT2DMincludingsmoking,alcoholconsumptionandregularexerciseseemednotassociatedwiththedevelopmentofDR.CONCLUSION:Ourstudysuggeststhatfastingserumglucoseconcentration,HbA1clevel,durationofdiabetesandinsulintreatmentarepotentialriskfactorsforDRinnorthernChinesepatientswithT2DM,whilethelifestyleofincludedpatientsseemsnotassociatedwithDR.

简介：AIMTo在在为复杂网膜的detachment.METHODSWe经历retinectomy的病人的硅酮油(ROSO)的移动执行了为复杂网膜的分开在retinectomy以后经历了ROSO的病人的回顾的盒子笔记评论以后，评估功能的结果。有不到6mo的病人列在后面在上面并且周期性的网膜的分开追随者ROSO是excluded.RESULTSThirty--六个病人被包括。吝啬的最好改正的视觉尖酸(BCVA)pre-ROSO是1.13logMAR(SD0.5)。吝啬的BCVA3mo追随者ROSO是1.16logMAR(SD0.53)，6mo追随者ROSO1.13(SD0.63)，和跟随ROSO1.18(SD0.69)的12mo。在在ROSO以后的12mo，BCVA在38.9%病人改善了，在25%仍然保持未改变，并且尽管在在在3点的ROSO以后的BCVA没有统计重要差别，在36.1%败坏了，6并且12mo(P=0.93)。retinectomy的尺寸从15°；到270°；(SD53)并且没影响.CONCLUSIONThere是的视觉结果(P=0.11)在在pre-和柱子之间的BCVA的没有统计上重要的差别--为复杂网膜的分开的ROSO后面的retinectomy。在与retinectomy的尺寸有关的视觉结果没有统计差别。

简介：Clinicaloutcomesarepositivelyassociatedwithhematomaabsorption.Themonocyte-macrophagescavengerreceptor,CD163,playsanimportantroleinthemetabolismofhemoglobin,andasolubleformofCD163ispresentinplasmaandothertissuefluids;therefore,wespeculatedthatserumCD163affectshematomaabsorptionafterintracerebralhemorrhage.Patientswithintracerebralhemorrhageweredividedintohigh-andlow-levelgroupsaccordingtotheaverageCD163level(1,977.79±832.91ng/mL).Comparedwiththehigh-levelgroup,thelow-levelgrouphadasignificantlyslowerhematomaabsorptionrate,andsignificantlyincreasedNationalInstitutesofHealthStrokeScalescoresandmodifiedRankinScalescores.TheseresultssuggestthatCD163promoteshematomaabsorptionandtherecoveryofneurologicalfunctioninpatientswithintracerebralhemorrhage.

简介：AIMTo与类型2糖尿病mellitus(T2DM)在中国病人的一个队调查在C反应的蛋白质(CRP)和糖尿病的retinopathy(医生)之间的关系基于.METHODSCommunity的观察的队学习。有1131个参加者，在城市的北京在Desheng社区从2009年11月招募到2011年9月。病人们诊断了T2DM被招募并且经历由一张问询表，眼睛、人体测量的检查和实验室调查组成的标准化评估。医生的存在和严厉由七个领域被估计30°；渲染宫底相片。题目然后没有医生，任何医生，或威胁视觉的克尔普博士被分类进组与T2DM从1007个病人全部的学习subjects.RESULTSA的浆液被分析为分析被包括，包括408(40.5%)男人并且599(59.5%)女人。中部的CRP水平为男人是为女人和1.1mg/L的1.5mg/L(P=0.004，或0.37，95%CI0.18-0.74)。在为可能的covariates调整以后，CRP的高水平与任何医生的更低的流行被联系(P=0.02，或0.55，95%CI0.35-0.89)，然而并非与威胁视觉的医生联系了(P=0.62，或0.78，95%CI0.28-2.14)。在由性的层化以后，在CRP和医生之间的反的协会被发现在男人统计上重要(P=0.006，或0.35，95%CI0.16-0.73)，然而并非在女人(P=0.58，或0.88，95%CI0.29-1.16)与T2DM从一张中国人口拉的.CONCLUSIONThe数据建议那增加的CRP层次可以相反地与医生的开发被联系。