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简介：目的：探讨脑电地形图与脑CT在脑感染性疾病诊断中的应用价值。方法：脑电地形图和脑CT在99例患有脑感染性疾病患者中被检查了并且进行了对比。结果：在疾病的定性和定位诊断中,脑电地形图和脑CT是一致的。但是,在阳性率方面,散发性病毒性脑炎在脑电地形图中94例是阳性,而在CT中只56例是阳性。结论：脑电地形图在脑感染性疾病的诊断中有重要应用价值。

简介：ObjectiveToreportuseoftheVibrantSoundbridge(VSB)inpatientswithcongenitaldeformationofthemiddleandouterearsandinvestigateitsutilityinthispatientpopulation.MethodFourpatientswithcongenitaldeformationofmiddleandouterearsunderwentVSBimplantation.Allweremale(aged3-18years,average13.5years)andoperatedontheleftside.Malformationwasbilateralin3patientsandunilateralin1patient.Surgicaltechniquesweremodifiedtoaccommodateeachpatient’suniqueconditionsandneeds.Theimplantsitewasapproachedviathefacialrecessin3patientsandthrougharetro-facialnerveroutein1patient.TheVSBimplantwasconnectedtoeitherthestapes(2cases)ortheroundwindow(2cases).PuretoneandspeechaudiometryresultsanddailycommunicationcapabilitiesbeforeandafterVSBactivationwerecompared.ResultsTheoperationsweresuccessfulinallpatients,withnocomplications.ThepatientcommunicationlevelimprovedsignificantlyafterVSBactivation.Averageairconductionpuretonethresholdorconditionedreflexaudiometrythresholdimprovedby35dBinthe0.25-4kHzrange,from69dBHLbeforeVSBactivationto34dBHLafter.Thesentencerecognitionrateinquietat65dBSPLwentupto86%from0%withoutVSBforpatientswithbilateraldeformationandremainedat100%forthepatientwithunilateraldeformity.However,forthelatterpatient,therateimprovedto20%from0%withoutVSBinnoise(-8dBSNR).ConclusionVSBisanexcellentsolutionforimprovinghearinginpatientswithcongenitaldeformationofmiddleandouterears.Operationcanbecompletedandgoodresultscanbeachievedeveninpatientswithuniqueconditionsandneeds.

简介：BackgroundArrhythmogenicrightventricularcardiomyopathy(ARVC)isamajorcauseforsuddencardiacdeathduetoventriculartachycardia.Litterisknownaboutitslong-termoutcomesinChineseARVCpatients.Thepurposeofthisstudywastoevaluatethelong-termclinicaloutcomesinpatientswithARVCandtoclarifytheriskfactorsofcardiacevents.MethodsFortysubjectsfulfillingmodifiedTaskForcecriteriawereincludedinthisstudy.Informationonclinicalpresentation,electrocardiographicandcardiacimagingfindings,andlong-termoutcomeofcaseswereinvestigated.ResultsAveragefollow-upperiodfromonsetwas57.5±42.6months.Themeanageatonsetofsymptoms(32.2±12.7years)andmalepredominance(85.0%)weresimilartothatreportedinotherstudies.Palpitationswerethemostfrequentsymptom(82.5%).T-waveinversionwasthemostcommonpresentingabnormalityonresting12-leadECG(75%).Ventriculartachycardiawithleftbundlebranchblockmorphologywassubsequentlydocumentedinatotalof28(70%)subjectsduringastudyperiod.Thecumulativemortalityratewas7.5%.ConclusionClinicalpresentationinChineseARVCpatientswassimilartothatreportedinotherstudies.ARVCisassociatedwithearlymortalitythatisdifferenttoothercountrypopulation.

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简介：<正>Background:Centralsensitizationhasbeenassociatedwithchronicpaininwhiplashpatients.Methods:Consecutivewhiplashpatientswereassessedat3monthspost-whiplashinjurywiththebrachialplexusprovocationtest(BPPT)asasignofcentralsensitization.Self-reportedrecoverywasassessedbytheresponsetothequestion’Doyoufeelyouhaverecoveredfullyfromyouraccidentinjuries?’Results:Sixty-ninesubjects(32males,37females,age37.5±13.0years(mean±SD),range18—71)wereincluded.Ofthese,34reportedalackofrecovery,and35reportedrecoveryat3monthspost-injury.ThemeanBPPTelbowextension(from180°)was41.5±23.0°,andthemeanVASscorefortheBPPTwas2.2±1.2(outof10).ThosewhoreportedrecoveryhadameanBPPTelbowextensionangleof25.1±15.8whilethosewhodidnotreportrecoveryhadameanBPPTangleof58.4±15.9(P<0.05).Thevisualanaloguescale(VAS)scoreforrecoveredsubjectswas1.8±1.1and2.7±1.1(P<0.05)fornon-recovered.Therewasamoderatecorrelationbetweenself-reportedrecoveryandBPPTelbowextensionangle(—0.44)andalowercorrelationbetweenself-reportedrecoveryandVASscore(-0.30).Conclusion:Self-reportedrecoverycorrelateswellwithalowerlikelihoodofsignsofcentralsensitization.

简介：BackgroundMyocardialdamageoftenoccursafterburns.Previously,cardiacenzymeprofilewasoftenmeasuredtodeterminemyocardialinjury,butwashardlyspecific.Inthisstudy,weinvestigatedearlychangesofplasmaN-terminalpro-brainnatriureticpeptide(NT-proBNP)overtimeanditsdiagnosticvalueinburnedpatients.Methods39patientswithheatburnedwereassignedtoheartfailuregroup(n=9),controlgroup(n=30).PlasmaNT-ProBNPandtroponinI(cTnT)weremeasuredat1st,3rd,5thdaysand7thday,andpatientsweresubdividedinto2groupsaccordingtotheircardiacfunction.ResultsNinepatientshadheartfailure(27.7%)andtheirNT-proBNPwas1676.03±2190.41pg/L.Significantdifferencewasfoundbetweentheheartfailuregroupandcontrolgroup(P<0.01).ConclusionNT-proBNPisrelatedtotheseverityofburningandcanwellreflectthestatusofmyocardialinjuryinpatientswithsevereburn,andcanbeusedasanidealmarkerformyocardialinjuryinburnedpatients.

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简介：Levofloxacin是通常被用来对待长期的细菌的前列腺炎的合成fluoroquinolone。我们在中国病人为长期的细菌的前列腺炎的治疗与ciprofloxacin相比调查了levofloxacin的安全和功效。这是multicenter，开标签的、使随机化的控制非低劣试用。有临床的症状/症状的471个病人被注册进学习，并且408个病人是微生物学地证实的长期的细菌的前列腺炎，被使随机化到也口头的levofloxacin(500 ；mgq.d)或ciprofloxacin(500 ；mgb.i.d)为4个星期。细菌的清理率，临床的症状/症状，不利反应和疾病复发被估计。临床的症状和症状和在与levofloxacin对待的209个病人和与ciprofloxacin对待的199个病人的细菌文化(包括的尿痛，会阴的不快或疼痛)是类似的。最普通的细菌是Escherichiacoli和葡萄球菌aureus。在4星期治疗的结束以后的一～四个星期，细菌的清理率(86.06%；对60.03%；P<；0.05)并且临床的功效(包括临床的痊愈和临床的改进(93.30%；对71.86%；P<；0.05))比在对待ciprofloxacin的组在对待levofloxacin的组是显著地更高的。microbiological复发率比在对待ciprofloxacin的组在对待levofloxacin的组是显著地更低的(4.00%；对19.25%；P<；0.05)。不利事件和处理相关的不利事件的率比在对待ciprofloxacin的组在对待levofloxacin的组是稍微更低的。Levofloxacin以临床的功效和疾病复发在ciprofloxacin上显示出一些优点，与不利事件的低率，为在中国病人的长期的细菌的前列腺炎的治疗。

简介：Thisstudyinvestigatedtheeffectofcatheter-basedrenalsympatheticdenervation(RD)onleftventricularhypertrophy(LVH)andsystolicanddiastolicfunctioninpatientswithresistanthypertension.LVHanddiastolicdysfunctionareassociatedwithelevatedsympatheticactivityandincreasedmorbidityandmortality.TheeffectofRDonLVHandLVfunctionisunclear.MethodsandResultsForty-sixpatientsunderwentbilateralRD,and18patientsservedascontrols.Transthoracicechocardiographywasperformedatbaseline,andafter1monthand6months.Besidesreductionofsystolicanddiastolicbloodpressure(-22.5/-7.2mmHgat1monthand-27.8/-8.8mmHgat6months,P<0.001ateachtimepoint),RDsignificantlyreducedmeaninterventricularseptumthicknessfrom14.1±1.9mmto13.4±2.1mmand12.5±1.4mm(P=0.007),andLVmassindexfrom53.9±15.6g/m(2.7)(112.4±33.9g/m(2))to47.0±14.2g/m(2.7)(103.6±30.5g/m(2))and44.7±14.9g/m(2.7)(94.9±29.8g/m(2))(P<0.001)at1monthand6months,respectively.ThemitralvalvelateralE/E'decreasedafterRDfrom9.9±4.0to7.9±2.2at1monthand7.4±2.7at6months(P<0.001),indicatingreductionofLVfillingpressures.Isovolumicrelaxationtimeshortened(baseline109.1±21.7msvs.85.6±24.4msat6months,P=0.006),whereasejectionfractionsignificantlyincreasedafterRD(baseline:63.1±8.1%vs.70.1±11.5%at6months,P<0.001).Nosignificantchangeswereobtainedincontrolpatients.ConslusionsBesidestheknowneffectonbloodpressure,ourstudyshowedforthefirsttimethatRDsignificantlyreducesLVmassandimprovesdiastolicfunction,whichmighthaveimportantprognosticimplicationsinpatientswithresistanthypertensionathighcardiovascularrisk.

简介：讨论屏蔽2002的营养的风险(NRS2002)是否为营养的风险在造血的干细胞移植(HSCT)前后为白血病病人屏蔽是适当的，并且是否在其它有风险差别的目的调节，例如年龄，性和匹配的度；发现营养的风险在HSCT前后为这些病人屏蔽的方法和指示物，处理以便给及时干预保证全部移植的成功的结束。99个白血病病人的方法营养的风险在HSCT前后与NRS2002被屏蔽。，2测试被使用比较象年龄，性和匹配的度那样的组之间的风险差别另外的枚举数据的差别，例如最近(13个月)重量损失，在一个星期和BMI以内的减少的食物吸入，被连续性修正比较。99个白血病病人，结果22个盒子(22.2%)在HSCT前有营养的风险，当所有病人在HSCT以后有营养的风险时；有在在男性和女性之间的营养的风险的没有重要差别，和不到30岁的病人，不完整匹配，最近(13个月)重量损失，在一个星期或BMI以内的减少的食物吸入<18.5是更可能的有营养的风险；并且77个盒子(77.8%)有重量损失，49个病人(63.6%)在一个月以内在之中有超过5%重量损失。这研究显示出的结论白血病病人竟然收到在HSCT，和NRS2002前后通常屏蔽的营养的风险，这为营养的风险在HSCT前屏蔽仅仅是适当的。更多的注意应该对病人被给予不到30岁或不完整匹配。重量变化是为在HSCT以后的病人的重要营养的指示物之一。

简介：客观刺猬(HH)的激活小径包括hepatocellular癌(HCC)在人的恶意的发展被含有。然而，在HCC病人的HH激活的临床的影响仍然是不清楚的。这研究被进行证实HH小径部件的表示是否与HCC前进和临床的结果被联系。这研究是的方法一膨胀样品、延长列在后面在上面我们的以前的研究之一。它包括了从2002～2005经历了外科的治疗的46个HCC病人。声音的HH(嘘)的表示，patched-1(PTCH1)，smoothened(SMOH)和在肿瘤和邻近的正常纸巾的基因从病人提取了的联系glioma的oncogene-1(GLI1)被反向的transcriptionpolymerase链反应(RT-PCR)检验探索在这些基因和HCC的临床的预后之间的关系。表示在HCC纸巾嘘，PTCH1，SMOH和GLI1铺平的结果分别地是60.87%，50.00%，32.61%和54.35%。嘘相关的分子的表示层次在癌症织物是相对强烈的，但是不足道与肿瘤的任何clinicopathological因素相关。Transcriptional因素GLI1是在HCC病人之中与差的预后联系的唯一的分子。在肿瘤纸巾的GLI1基因的表示显著地与没有疾病的幸存(DFS)(P=0.042)和全面幸存(OS)(P=0.030)被联系。在肿瘤和邻近的正常的肝纸巾的GLI1的同时的表示与DFS相关(P<0.029)并且OS(P<0.025)。结论HH发信号激活是在人的HCC的发展的一个重要事件。在嘘小径的GLI1的表示可能涉及HCC前进，它可以是HCC的有用预示的指示物。

简介：比较在主要debulking外科(PDS)和neoadjuvant化疗之间的幸存和perioperative病态的目的在与先进上皮的卵巢的癌症(EOC)对待病人由间隔debulking外科(NAC/IDS)列在后面。我们回顾地与阶段IIIC或IVEOC考察了67个病人的方法从2006年1月在北京大学癌症医院对待到2009年6月。在那里，37和30个病人分别地经历了PDS和NAC/标志。结果在全面幸存(OS)或没有前进的幸存(PFS)的差别都没在NAC/IDS组和PDS组之间被观察(OS：41.2对39.1个月，P=0.23；PFS：27.1对24.3个月，P=0.37)。最佳的debulking率在NAC/IDS组是60%，它在PDS组(32.4%)(P=0.024)比那显著地高。NAC/IDS组显著地有比PDS的肠的功能的估计的血损失和输送，更低的nasogastricintubation率，和更早的移动和恢复组织的更少的intraoperative(P<0.05)。结论NAC/IDS不比PDS侵略，并且关于最佳的cytoreduction率，intraoperative血损失，和手术后的恢复提供优点，没有显著地损害与在对待有阶段IIIC或IVEOC的病人的PDS相比的幸存。因此，NAC/IDS可以是为EOC病人的一种珍贵治疗选择。

简介：客观试验性的证据建议胸的overexpression癌症特定的肿瘤suppressor蛋白质1(BRCA1)基因提高敏感到docetaxel和抵抗到cisplatin和ribonucleotidereductaseM1(RRM1)基因overexpression提高抵抗到gemcitabine。为了进一步检验BRCA1和RRM1mRNA的效果，在先进非小的房间肺癌症(NSCLC)在结果上铺平，我们执行了测试了那设定的治疗将授与的假设的这非使随机化的阶段II临床的审判在noncustomized上的改进结果治疗。

简介：BackgroundAnomalousoriginoftheleftcoronaryarteryfromthepulmonaryartery(ALCAPA)isararecongenitalanomaly.Itdemonstratedthecombinedeffectsoftheabsenceofanormalcoronaryflowwithacoronarystealandtheprofoundischemiathatcanproduceleftventriculardysfunctionandmitralregurgitation.Wehereintroducethepostoperativemanagementofpatientswithrepairofanomalousoriginoftheleftcoronaryarteryfromthepulmonaryartery,withanemphasisonitsoutcome.MethodsRecordsof31patientswithanomalousoriginoftheleftcoronaryarteryfromthepulmonaryarteryreceivingsurgeryfrom1998to2010werereviewedretrospectively,10ofwhichweretreatedwiththemitralvalvesurgicallyatthesametime.Theageofpatientswas4monthsto16years(median,1year)andweightofthosewas5to53kilograms(median,7.8kilograms),allofwhichwerediagnosedofanomalousoriginoftheleftcoronaryarteryfromthepulmonarybyechocardiographyandcardiaccatheterization.Aftersurgery,electrocardiogram,echocardiography,arterialbloodpressure,transcutaneousoxygensaturationandcentralvenouspressureweremonitored.Commonpostoperativecomplicationsinourgroupwereanalysed.Andpreoperativeandpostoperativedataincludingareaofmitralregurgitation,leftventricularsystolicdiameterandleftventriculardistolicdiameterwereobtained.Cardiopulmonarybypasstimeandmechanicalventilationtimeofpostoperativepatientswithnopneumoniawerecomparedwiththosewithpneumonia.Binarylogisticregressionwasappliedfortheanalysisoftheriskfactorsofpostoperativepneumonia.ResultsOf31patients,30survivedaftersurgerywithearlymortalityof3.23%.Onepatientdiedofseverelowcardiacoutputsyndrome.Mechanicalventilationtimewas4hoursto168hourshours(mean,39.68±50.52hours;median,18hours).ICUstaywas16hoursto425hours(mean,111.65±127.03hours;median,44hours).Inourgroup,commonpostoperativecomplicationsweremyocardialischemia(n=12,36.4%),infection(n=

简介：在病人作为首要或第二线的治疗评估paclitaxel，cisplatin和5-FU(PCF)的联合政体的功效和毒性与的目的进展胃并且在中国的esophagogastric连接(EGJ)腺癌。病人与paclitaxel被对待的方法d1上的150mg/m2；fractionatedcisplatin15mg/m2和连续注入5-FU600mg/(m2朠楬污映扩楲汬牡????????????М

简介：BackgroundTheCHA2DS2-VAScschemahasrecentlybeenintroducedtocomplementtheCHADS2scoreandimprovetheidentificationofatrialfibrillation(AF)patientsat'trulylowrisk'forthromboembolism.WetestedthepredictiveabilityoftheCHA2DS2-VASc,CHADS2andvanWalravenriskstratificationschemesinacohortof'lone'AFpatientswitha12-yearfollow-up.MethodsandResultsWeconductedaregistry-based,observationalcohortstudyof345patientsinitiallydiagnosedwith'lone'AFbetween1992and2007.Atbaseline,allpatientshadtheCHADS2andvanWalravenscoresof0,and262(75.9%)hadaCHA2DS2VAScscore=0.Duringfollow-up(orwithinayearpriortostroke),228(66.1%),234(67.8%)and150patients(43.5%)retainedtheCHADS2,vanWalravenandCHA2DS2VAScscoresof0,respectively.Theoverallrateofischemicstrokewas0.19(95%CI:0.18-0.20)per100patient-years.Inthemultivariableanalysis,onlytheCHA2DS2-VAScscoreof0wassignificantlyrelatedtotheabsenceofstroke(OR5.1,95%CI:1.5-16.8,P=0.008).OnlytheCHA2DS2-VAScscorehadasignificantpredictionability(c-statistic0.72[0.61-0.84],P=0.031).ConclusionsTheCHA2DS2-VAScscorereliablyidentifiedthe'lone'AFpatientswhowereat'trulylowrisk'forthromboembolism,andwastheonlytestedriskstratificationschemewithasignificantpredictiveabilityforthromboembolismamongstloneAFpatients.

简介：BackgroundTotheeffectofpercutaneouscoronaryintervention(PCI)onplasmalevelofN-terminalpro-Btypenatriureticpeptide(NT-proBNP)inpatientswithcoronaryheartdisease(CHD)andnormalleftventricularfunction.MethodsOnehundredandfivepatientswithCHDandnormalventricularfunctionwereenrolled.BloodsamplesforassessmentofNT-proBNPandcTn-TwerecollectedbeforeandafterPCI.ResultsThemeanleftventricularejectionfractionwas60.3±5.3%.Afterrevascularization,theleveloflgNT-proBNPwassignificantlyreduced(2.40±0.44vs2.23±0.43,P<0.001).SubgroupanalysisshowedthattheleveloflgNT-proBNPwasconsistentlydecreasedindifferentclinicalclassifications(stableangina45,unstableangina31andacutemyocardialinfarction29)andtarget-vesselrevascularization(leftanteriordescendingartery30,leftcircumflexartery26andrightcoronaryartery49),andin99patientswithoutelevationofpost-proceduralcTnT,butitshowedatrendofnon-significantincreasein6patientswithelevatedcTn-T.ConclusionsOurstudydemonstratesthatsuccessfulPCIreducesplasmaNT-proBNPconcentrationinpatientswithCHDandnormalventricularfunction.ThisimplicatesthattheimpactofPCIshouldbeconsideredintheinterpretationofNT-proBNPchangeinclinicalpractice,andfurtherstudiesarenecessarytoinvestigatethedirectand/orindirecteffectofmyocardialischemiaonBNP/NT-proBNP.

简介：BackgroundIntra-aorticballoonpump(IABP)hasbeenwidelyusedatpresent.Wecanuseitatdifferentstagesofperioperativeperiodinoff-pumpcoronaryarterybypassgrafting(CABG).However,whentouseditwasseldomconfirmed.MethodsFromJanuary2008toJune2012,the89coronaryheartdisease(CHD)patientsacceptedimplantationofIABPatdifferentstagesofoff-pumpCABG,preoperativeandpostoperativeventricularsystolicfunction,leftventricularremodelingsituationandthechangesofmyocardialenzymeswereevaluated.ResultsAllthepatientshadleftheartinsufficiencyandmultivesseldisease.TheirpostoperativeleftventricularsystolicfunctionandventricularremodelingweresignificantlyimprovedwhilemyocardialenzymesdecreasedwithpreoperativeinterventionalimplantationofIABP.Theperioperativemortalitywas7.86%(7/89).NopatientshadcomplicationofIABP.ConclusionEarlierIABPimplantationatpreoperationisusefultoimproveheartfunction,improvethetolerabilityofsurgery,reducetheincidenceofpostoperativelowcardiacoutputsyndrome(LCOS)anddecreasethemortality.