学科分类
/ 5
90 个结果
  • 简介:4-Amino-5-(pyridin-3-yl)-4H-1,2,4-triazole-3-thiol1werecondensedwith2-bromo-1-(substitutedphenyl)ethanonetogivepyridinyltriazolothiadiazines2a~c,whichwerequaternarizedwithmethyliodideandoxidizedwith30%hydrogenperoxidetoaffordthecorrespondingmethylpyridiniumsalts3a~candpyridine-l-oxides4a~c,respectively.Thereductionofcompounds3and4withNaBH4inmethanolproducedthetargetcompounds1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-6-aryl-s-triazolothiadiazines5a~cand3-(1-hydroxyl-1,2,5,6-tetrahydropyridin-3-yl)-6-aryls-triazolothiadiazines6a~c,respectively.Theendotheliumvascularrelaxingactivityofthetargetcompoundswasscreened.

  • 标签: 合成 四-羟基嘧啶三吡咯噻二嗪 蕈毒碱兴奋剂 活性 吡啶盐
  • 简介:边脱臼在的紧张精力在外部静电干扰,磁场被弹性和electrodynamics的理论为连续媒介根据Volterra脱臼模型的意见决定。处于顺磁的状态的边脱臼的紧张精力由于在脱臼的精力的静态的磁场和增加被增加的结果表演能够影响导致粘性的变化的脱臼depinning。这给生病磁场导致的粘性上的解释。

  • 标签: 可塑性 磁场 边缘位错 电动力学
  • 简介:FollowingtheeruptionofEuropeandebtcrisisinthewakeofthefinancialcrisis,anewdebtcrisisbegantofermentontheUSsoils.OnMay16th,withUSdebtexceedingitsstatutoryceilingof$14.29trillion,USTreasury'ssolvencybecamesostretchedthatitcouldhardlylasttoAugust2nd.Asaresult,thecountrywasplungedintogreatdefaultrisks.Thetwoparties,throughheatedpoliticalstruggles,finallymanagedtoreach

  • 标签: 债务 美国 金融危机 美元 国债
  • 作者: 孟轩宇
  • 学科: 医药卫生 > 临床医学
  • 创建时间:2020-04-20
  • 出处:《医师在线》 2020年第6期
  • 机构:Since after the outbreak of COVID-19 happened in China, an increasingly more of confirmed cases and death cases have been reported. It is crucial to find a potential treatment for this epidemic. Based on the information provided by researchers, this virus is based on the RNA, cutting down the duplication of RNA can eventually inhibit the process of generating the protein, which is essential to the diffusion of virus. Fidaxomicin, a medicine that has a function to inhibit the polymerase in the process of transcription, which is one of those two processes of protein-generation. So, this medicine can theoretically inhibit the illness.
  • 简介:

  • 标签:
  • 简介:成长观察表明软gamma光线重复ers和异常x-raypulsars是磁铁艺术。他们的磁场可以完成10(14)-10(15)G。我们由在中子星(NS)内考虑P-3(2)超流体中子的磁化探索超级强壮的磁场的起源。由Elgaroy由和状态的方程解决Tolman-Oppenheimer-Volkov方程采用了它等。[Phys。加快。Lett。77(1996)1428]在配对差距的中子的计算,我们明确地计算NS内部结构,为在NS内的P-3(2)超流体中子的可允许的区域,和有序的安排中子旋涡贡献的全部的磁性的时刻。结果证明导致的磁场可以盖住一个宽范围,它与磁场下面为脉冲星纺纱由标准磁性的偶极子放射预言了一致。

  • 标签: 可能机理 超强磁场 软γ射线中继器 X射线脉冲 偶极辐射 脉冲星
  • 简介:Thispaperstudiesthemodel-robustdesignproblemforgeneralmodelswithanunknownbiasorcontaminationandthecorrelatederrors.ThetrueresponsefunctionisassumedtobefromareproducingkernelHilbertspaceandtheerrorsarefittedbytheqthordermovingaverageprocessMA(q),especiallytheMA(1)errorsandtheMA(2)errors.Inbothsituations,designcriteriaarederivedintermsoftheaverageexpectedquadraticlossfortheleastsquaresestimationbyusingaminimaxmethod.Acaseisstudiedandtheorthogonalityofthecriteriaisprovedforthisspecialresponse.Therobustnessofthedesigncriteriaisdiscussedthroughseveralnumericalexamples.

  • 标签: 误差模型 稳健设计 再生核希尔伯特空间 移动平均过程 偏差 最小二乘估计
  • 简介:WediscussthebosonizationofarelativisticverydenseFermigasinamagneticfieldandtheconsequentBoseEinsteincondensationoftheresultingrelativisticvectorgasofchargedparticles.Themodelmaybeappliedtopairedspin-upelectrons.Weshowthatsuchsystemsmaymaintainself-consistentlymagneticfieldsoforder10^10-10^13G.Thatpairingcouldbetheoriginoflargemagneticfieldsinsomewhitedwarfsandneutronstars.Forfieldslargeenough(-10^13forwhitedwarfs),thesystembecomesunstableandcollapses.

  • 标签: 磁场 费米气体 量子数 玻色子方程
  • 简介:Themechanismofesterhydrolysishasbeenextensivelystudied;however,theprecisefunctionofactive-siteresiduesinpromotingcatalysisisunclear.WedescribeherethestructuralmodelsforthecomplexofacatalyticantibodyFvfragmentwithaphosphonatetransition-stateanalogue,constructedbyusinggenecloning,sequencingandmolecularmodeling,mainlybasedonaknownX-raystructureofacatalyticantibody.HydrophobicandelectrostaticanalysesoftheFv/analogandFv/substrateinteractionsuggestthehydrolysismechanism:TyrL91andTyrH97playimportantrolestostabilizetheβ-naphthylgroupofhaptenthroughπ-stack;HisH35donatesapairoffreeelectronsattheatomNE2toanactivewaterandletittobeapartialhydroxide,whichattacksthecarbonatomofthecarbonylgroupofthesubstrate.BothHisH35andArgL96canformhydrogenbondsandstabilizetheanionictetrahedralintermediateformedduringturnover.Thismechanismemphasizesthatanactivewaterbridgemaybeformedduringhydrolysisprocess.

  • 标签: 水解机制 催化抗体 基因克隆 分子模型 酯类 β-萘乙酸酯