简介:Three-dimensional-printed(3D-P)titaniumimplantsdisplaymanyadvantages,suchasdesignflexibility,higherefficiency,thecapabilitytoeasilyconstructcomplexorcustomizedstructures,etc.,andisbelievedtopotentiallyreplacetraditionalimplants.However,thebiologicalperformanceofthe3D-Ptitaniumsurfacehasnotbeeninvestigatedsystematically.Herein,weanalyzedthesurfacecharacteristicsof3D-PTi6AI4Vimplantsandevaluatedthebiologicalresponsesofbonemarrowderivedmesenchymalstromalcells(BMSCs)tothe3D-Psurfaceinvitro.Moreover,afterimplantationintotheratfemoralcondylefor3and6weeks,theosseointegrationperformaneewasevaluated.Theresultsshowedthe3D-PTi6Al4Vimplantpresenteddistinctfluctuantmacroscaleroughsurfaceandrelativelybetterhydrophilicitywhichenhancedtheadhesion,proliferation,osteogenicdifferentiationandangiogeneticfactorexpressionofBMSCs.Moreover,theinvivoosseointegrationperformancewasalsobetterthanthatofthecontrolgroupattheearlystage.Thepresentstudysuggestedthe3D-Ptitaniumalloyisapromisingcandidatetobeusedasimplantmaterial.
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简介:来临三维(3-D)打印了技术在设定的多孔的钛(Ti)的制造提供大可能性植入。然而,打印Ti的bioinert性质提出一个突出的问题。混合微弧的氧化并且热水(MAO-HT)多孔的金属上的处理能生产multi-scaled层次矫形植入,为3-D的表面修正的出现大潜力打印了植入。在这研究,有毛孔的圆柱的多孔的Ti6Al4V(Ti64)脚手架640缩放吗??