简介:摘要目的探讨晚期食管鳞癌患者放化疗的疗效,分析其预后影响因素。方法收集2002—2016年10所医疗中心608例Ⅳ期食管鳞癌患者的病历资料和随访资料,分析患者预后的影响因素。结果ⅣA期食管鳞癌患者的1、3、5年生存率分别为66.7%、29.5%和24.3%,ⅣB期患者分别为58.8%、29.0%和23.5%,两组之间差异无统计学意义(P=0.255)。单因素分析结果显示,病变长度、治疗方案、计划肿瘤体积(PGTV)剂量、是否序贯化疗、贫血程度、放射性食管炎程度、放射性肺炎程度与Ⅳ期食管鳞癌放化疗患者的预后有关(均P<0.05)。多因素分析显示,PGTV剂量(OR=0.693, P=0.004)、放射性食管炎程度(OR=0.867,P=0.038)、放射性肺炎程度(OR=1.181,P=0.004)是Ⅳ期食管鳞癌患者放化疗预后的独立影响因素。结论对Ⅳ期食管鳞癌推荐放化疗后序贯化疗的综合治疗方案,能够延长患者的总生存时间,改善患者的预后。PGTV剂量≥60 Gy疗效较好。
简介:ToanalyzethegenomicmolecularstructureandgenotypeofhumanastrovirusisolatedfrominfantinGuangzhouofChina,theprimersweredesignedbasedonthegenomicsequenceofastrovirusfromtheGenBankandthetargetsequencewereamplifiedbyRT-PCR.ThenthePCR-productswereclonedtoTvectorandsequenced.ThegenomicnucleotidesequenceswereanalyzedbytheprogramsCLUSTALWandDNASTAR.ItwasfoundthatthefullgenomiclengthofHASTVgz01strainwas6721bpandtheORFswere6558bp.The5'and3'UTRwere82and81nucleotides.Thegenomeincluded3openreadingframes(ORFs):ORF1a,ORF1bandORF2.The5'-terminalORF1astartedatnucleotide83andextendedtonucleotide2845.ORFlb(nt2785tont4332)overlapedORFlaby61nucleotides.The3'-terminalORF2beganatnucleotide4325andterminatedatnucleotide6640.ORF2had2316nucleotides.ComparedwithotherastrovirussequencesinGenBank,thehomologyoftheaminoacidsequenceofORF2ofHASTVgz01strainwiththatofserotype4was93%.Homologywithotherserotypesrangedfrom61%to70%.ThecompletenucleotidesequenceofastrovirusHASTVgz01strainisolatedfromGuangzhouinChinawas6721bpinlength,GenBankaccessionNO.DQ344027.ComparingtheORF2ofastrovirusHASTVgz01withtheknownsequencesoftypes1-8thehighesthomologywasserotype4(93%).ComparativesequenceanalysisoftheHASTVgz01ORF2withthereportedhumanastrovirussequencesrevealedthattheisolatedastrovirusbelongstogenotype(serotype)4.
简介:摘要:本文主要研究6F.01联合循环机组的热力性能,在此基础上分析朗肯循环热力性能,提出目前影响朗肯效率主要的两个因素为6F.01联合循环机组蒸汽压力以及温度的观点。数据显示如果改变循环机组的蒸汽压力值和温度,朗肯循环效率会随之改变,呈正相关,这一发现为后续优化同类属性的机组蒸汽组参数提供一定的理论依据。
简介:ThephaseandmorphologytransformationduringthehydrothermaltreatingprocessofY2O3wasevaluatedwithX-raydiffcrcnce(XRD),scanningelectronmicroscopy(SEM),transmissionelectronmicroscopy(TEM),particlesizeandspecificsurfaceareadetermination.TheresultsshowedthatthecubicY2O3didnottransferintohexagonalY(OH)3inpurewater.Therefore,purehexagonalY(OH)3withnanotubeandmicrorodmorphologieswereobtainedbyhydrothermaltreatingY2O3at150℃for12hin15mlof2mol/LNaOHsolutionwithandwith-outPVAorPEGItwassuggestedthatthecharacteristicpreferentialgrowthofY(OH)3wasattributedtothestructureanisotropyofhexahedronY(OH)3.TheadditionofPVAorPEGcouldpromotetheformingprocessofnanotubesbyselectiveadsorptionondifferentcrystalplanes,whichalteredthegrowthratealongdifferentdirectionsandresultedinthediffusionlimitofconstructingionsinthecentertopofrods.Finally,Y(OH)3:EuandY2O3:Eunanotubeswerealsosynthesizedbyusingthismethod,andtheirphotoluminescencepropertieswereevaluated.
简介:摘要:本教学设计案例围绕 预备单元(Starter Unit 3What color is it ? )展开。通过复习句型(What’s this/that? It’s an apple. What color is it? t’s red. Spell it ,please.It’s red)谈论物体颜色学习语法(an/a/the),同时训练学生听,说的能力 .本教学设计依据新课程标准要求,通过希沃游戏,大转盘游戏激发学生学习兴趣,采用图片直观教学法, 通过师生练习,小组练习,双人练习呈现新句型(It’s a red apple.The apple is red.),让学生观察发现总结 规律学习语法。通过完成听力任务培养学生抓住关键词寻找答案的听力技能,培养学生好的听力习惯 。同时以教材为本,结合实际,采用小组合作表演培养学生的口语技能和初步写作能力。本教学案例教学手段多样,使用希沃游戏教学,大转盘游戏,图片插入直观教学,图片裁剪,多媒体希沃白版5手机拍照视频上传,音乐剪辑插入播放等多种信息技术教学手段提高学生学习兴趣,调动学生积极性, 尽力让学生全体参与。教学过程中贯穿课程思政的理念,作业设计注重学生能力的培养。
简介:WeldingresearchofA6N01S-T5aluminumalloyprofileforhigh-speedtrainwasdonebyusinglaser-MIGhybridweldingandMIGweldingindividually.Andtheweldappearance,weldingdistortion,mechanicalpropertiesofthejointsandmicrostructureswereanalyzed.Thetestresultsdemonstratedthathigh-efficientweldingfortheprofilecanbeachievedbyusinglaser-MIGhybridwelding,thespeedofwhichcanbeover3.0m/min.Theprocessinghadagoodgapbridgingability,evenifthegapofthebuttjointwasupto2.0mm,agoodweldappearancecanalsobegot.Whilethehybridweldingspeedwasgreaterthan2.5m/min,theweldingdistortionofthelaser-tandemMIGhybridjointswasjustabout33%ofthatoftheMIGjoints,buttheweldingefficiencywasover3timesofMIGwelding.Andtensilestrengthofthehybridjointswas85%ofthatofA6N01S-T5basemetal,9%higherthanthatoftheMIGjoints.Fatiguepropertieswastestedindividuallywithpulsedtensilefatiguemethodintheconditionof1×107lifetime.Thetestresultsdemonstratedthatthefatiguestrengthofthejointswasalittlelowerthanthatofbasematerial,whichcouldbeupto115MPa.Butthefatiguestrengthofhybridweldingjointswas107.5MPa,whichwas23%higherthan87MPaofMIGweldingjoints.