简介：Theabilitytomodulatethefutureliverremnant(FLR)isakeycomponentofmodernoncologichepatobiliarysurgerypracticeandhasextendedsurgicalcandidacyforpatientswhomayhavebeenpreviouslythoughtunabletosurviveliverresection.MultipletechniqueshavebeendevelopedtoaugmenttheFLRincludingportalveinembolization(PVE),associatingliverpartitionandportalveinligation(ALPPS),andtherecentlyreportedtranshepaticlivervenousdeprivation(LVD).PVEisawell-establishedmeanstoimprovethesafetyofliverresectionbyredirectingbloodflowtotheFLRinanefforttoselectivelyhypertrophyandultimatelyimprovefunctionalreserveoftheFLR.ThisarticlediscussesthecurrentpracticeofPVEwithfocusonsummarizingthelargenumberofpublishedreportsfromwhichoutcomesbasedpracticeshavebeendeveloped.BothtechnicalaspectsofPVEincludingvolumetry,approaches,andembolizationagents;andclinicalaspectsofPVEincludingdatasupportingindications,anditsroleinconjunctionwithchemotherapyandtransarterialembolizationwillbehighlighted.PVEremainsanimportantaspectofoncologiccare;inlargepartduetothesubstantialfoundationofinformationavailabledemonstratingitsclearclinicalbenefitforhepaticresectioncandidateswithsmallanticipatedFLRs.

简介：Objective:Todetectthemodulationofcytokinesproductionbyacutepromyelocyticleukemia(APL)cellsbeforeorafterexposuretoall-transretinoicacid(ATRA).Methods:DiagnoseswereperformedaccordingtotheFABcytologicalclassificationcriteriaandcytogeneticcriteria.BonemarroworbloodsamplesfromAPLpatientswerecollectedinheparinizedmicrofugetube.PrimaryAPLcellswereseparatedandpurifiedbytraditionalFicoll-Hypaquedensitycentrifugationandenrichedafteradherencetoplasticsurfaces.IL-1(,IL-6,IL-8,TNF(andG-CSFlevelsinthesupernatantsofculturedleukemiacellswereestimatedbyELISAmethod.NBTmethodwasusedtodetectthedifferentiationofAPLcellsatthesametime.Results:96hafterexposuretoATRAat10-6Minvitroor60mg/dayinvivo,APLcellsshowedasignificantincreaseofIL-1((P<0.05)andG-CSF(P<0.05)production,andasignificantdecreaseofIL-6(P<0.05)andIL-8(P<0.05),however,therewasnoobviousvariationofTNF(.Ontheotherhand,theproliferationofAPLcellsinvitrowasstatisticallycorrelatedtotheIL-1(secretionorG-CSFsecretion.AndthecellnumberratioinpatientswithdetectableIL-1(orG-CSFwashigherthanthatwithoutdetectableIL-1(orG-CSF.Conclusion:IL-1(andG-CSFsecretionmayplayanimportantroleintheproliferationofAPLcellsafterexposuretoATRA.

简介：Astodeterminetheeffectofpost-remissiontherapyinprolongingsurvivalanddurationofremissionaftercompleteremission,50patientswithAPLIncompleteremissionInducedbyretinolcacid(RA)weredividedintothreegroupsrandomly:(A)30cases,treatedbyalternatechemotherapywithRA;(B)10cases,withRAalone;(C)10cases,onlywithchemotherapy.ThesurvivalcurvesshowedmatGroupAhadthesurvivaltimemorethan1yearIn87.4%,morethan2yearin80.7%.26/30casesweresurvivalandstillinremission,thesurvivalcurvetendtobeaplateauat16months.InGroupBmorethan1yearin45.7%.InGroupC,morethan1yearIn50%.(Keplan-Melerx2=8.93P<0.01).ThisresultshowedthatthealternatechemotherapywithRAforpost-InductionremissiontherapycouldbeusefultoImprovelong-termsurvivorsandtoprolongthedurationofremission.