简介:BackgroundRightbundlebranchblock(RBBB)maypresentasslurredornotchedSwaveinleadV1.However,slurredornotchedSwavemayalsorepresentslowconductioninthemyocardium.MethodsWeretrospectivelyanalyzedtheQRSpatternsinleadsV3RtoV5Rin7patientswithaslurredornotchedSwaveinleadV1.ResultsIntheleadsV3RtoV5R,6patientsshowedincompleteorcompleteRBBBand1patientslurredornotchedSwave.ConclusionsInthemajorityofECGsinasmallpatientserieswithslurredornotchedSwaveinleadV1,QRSmorphologyindicatingincompleteorcompleteRBBBwaspresentinleadsV3RtoV5R.AfindingoffragmentedQRSintheseleadsmayindicateslowconductioninthemyocardium.
简介:背景新生内膜形成是动脉粥样硬化、再狭窄等血管病理改变时的重要特征。阿托伐他汀能否通过抑制组织蛋白酶S(CatS)及核转录因子κB(NF-κB)表达减轻新生内膜形成目前尚不清楚。目的观察阿托伐他汀对大鼠颈动脉球囊损伤后CatS及NF-κB表达的影响。方法24只雄性SD大鼠分为正常对照组(n=8)、手术组(n=8)和阿托伐他汀组(n=8),手术组和阿托伐他汀组行左侧颈动脉球囊损伤。阿托伐他汀组予阿托伐他汀10mg/(kg·d)。实验前后测定血清白细胞介素1-β(IL-1β)变化,28d后大鼠处死行病理形态学检查,检测各组CatS和NF-κB表达。结果与手术组比较,阿托伐他汀组大鼠颈动脉内膜面积和内膜/中膜面积(I/M)比值明显减少,差异有统计学意义[内膜面积:(148.6±8.8)×103μm2比(64.8±5.1)×103μm2;I/M:(2.1±0.2)比(0.9±0.1),均P<0.01]。与手术组比较,阿托伐他汀组CatS表达和NF-κB评分也明显减少,差异有统计学意义[CatSmRNA:(0.80±0.07)比(0.50±0.04);CatS评分:(15.3±1.4)比(8.5±0.7);NF-κB评分:(12.5±1.3)比(6.7±0.5),均P<0.01]。内膜面积与CatS和NF-κB表达呈正相关(P<0.05)。结论阿托伐他汀可能通过抑制NF-κB使CatS表达减少,减轻颈动脉球囊损伤后新生内膜形成。
简介:Objectives:Apoptosisisrecognizedasanimportantmechanismincontrast-inducednephropathy(CIN).Cordycepssinensis(CS),atime-honoredtonicfoodandherbalmedicineinChina,canimprovethemicrocirculation,increasethetolerancetoischemiainpatientswithmicrocirculatorydisorders.AsCShasbeenfoundtoberenoprotectiveandanti-apoptoticinmultiplekidneyinjuries,wehypothesizedthatCSwouldpreventCIN.TheobjectiveofthisresearchistostudythemechanismofCSontubularepithelialcellapoptosisindiabeticCINrats.