简介:Treatmentof4-amino-3-(1-aryl-5-methyl-1,2,3-triazol-4-yl)-5-mercapto-1,2,4-triazoles/2-amino-5-(1-aryl-5-methyl-1,2,3-triazole-4-yl)-1,3,4-thiadiazoleswithbenzaldehyde,acetoneandω-bromoacetophenonewastestedandcompared.ThetitlecompoundsSchiffbases,amides,imidazolo[2,1-b]-1,3,4-thiadiazolesand7H-s-triazolo[3,4-b]-1,3,4-thiadiazineshavebeenconfirmedbyelementalanalyses,^1HNMR,IRandMSspectra.AllthecompoundshavealsobeenscreenedfortheirantibacterialactivitiesagainstB.subtilis,S.aureusandE.coli.
简介:
简介:Inthispaper,AgBF4/[emim][BF4]supportedionicliquidmembranes(SILMs)werepreparedsuccessfullyforCO/N2separationusingnitrogenpressureimmobilizationprocedures.TheincorporationofAgBF4coulddecreasemembraneweightloss,improvethepressure-resistantability,andkeepthecriticalpressure(0.45MPa)oftheSILMs.ThehighviscosityandundissolvedAgBF4solidsinmembraneliquidwoulddisturbgasmoleculartransportthroughmembraneandgiverisetothegastransportresistance.Therefore,thegaspermeabilitydecreasedremarkablywithincreasingAgBF4carriercontentinthemembrane.WhenthemolarratioofAgBF4to[emim][BF4]increasedfrom0:1to0.3:1,theCO/N2selectivityoftheSILMsshowedagreatincreasefrom~1to~9at20°Cand0.4MPa,suggestingthatAgBF4wasaneffectivecarrierforCOfacilitatedtransport.ThepermeabilitiesofN2andCOincreasedathighertransmembranepressure,indicatingthatmoleculartransportwoulddominatethetransportprocessathighpressure.Thetemperature-dependentgaspermeabilityfollowedtheArrheniusequation.Moreover,thedifferencesbetweentheactivationenergiesofCOandN2becamelargerafterintroducingAgBF4,resultinginmoreobviousdecreaseintheCO/N2selectivityathigheroperatingtemperature.
简介:采用工艺简单、条件温和的化学试剂脱水法制备了4,4,-双柠康酰亚胺基二苯甲烷。就影响CBMI收率的各因素:投料顺序、反应温度、反应时间、脱水催化剂体系等进行了探讨,通过实验得出了最佳操作条件。
简介:Fifty-sevenstations(48gridstationsandninestratifiedstations)weresampledacrossthestudyregion(67.000°–88.394°N,152.500°–178.643°W)duringthe4thChineseNationalArcticResearchExpedition(CHINARE4)fromJulytoAugust2010bytheicebreakerR/VXuelong.Atotalof24speciesofHydromedusaewereidentifiedfrom130zooplanktonsamples,ofwhichsevenspeciesbelongedtoAutomedusa,eightspeciestoAnthomedusae,fourspeciestoLeptomedudae,andthreespeciestoSiphonophora.CatablemamulticirratumKishinouye,1910,BougainvilliabitentaculataUchida,1925,andEuphysajaponica(Maas,1909)wererecordedforthefirsttimeintheArcticsea.Inthepresentpaper,18speciesofHydromedusaeweredescribedandillustrated,ofwhichthreespeciesweredescribedforthefirsttimeintheArcticsea,and15speciesweredescribedforthefirsttimeinChina.
简介:目的分析4例儿童Alport综合征的基因型和临床表型特点。方法总结4例患儿的临床特点,采用外显子捕获一第二代测序技术对4例诊断为Alport综合征患儿的COL4A5、COL4A4和COL4A3基因进行突变检测。结果4例均为男性,年龄6~8岁,首发症状均为血尿,均伴有不同程度的蛋白尿。1例表现为高频听力区受损,1例右侧视网膜脱色素改变。4例肾功能均正常。肾穿刺活检电镜检查均显示典型Alport综合征基底膜病变。在4个家系中发现4种COL4A5基因突变,分别为Glyl32Glu、Glyl238Arg、Gly267Arg和Glyl033Ser,均为未报道的新突变。经家系验证Glyl32Glu和Glyl033Ser为新生突变。用SIFT和PblyPhen软件进行蛋白功能预测均显示4种突变为有害突变。结论本研究采用外显子捕获一第二代测序技术共检测到4种COL4A5基因新突变,其中2种为新生突变。为人类Alport综合征基因突变数据库增添了4个新成员,对进一步研究中国人群Alport综合征的发病机制以及遗传咨询和产前诊断有重大意义。