简介：1984年毕业于上海医科大学，1990年获医学博士学位。现为教授，博士生导师，复旦大学附属眼耳鼻喉科医院院长，眼科主任，眼科研究所副所长，中华眼科学会中青年委员，全国青光眼学组副组长，上海市医学会眼科学会委员兼秘书，上海市医学会视光学会主任委员，上海市青光眼学组组长，复旦大学学术委员会委员。专业特长是：青光眼和视神经疾病，以及低眼压的诊治，从事难治性青光眼的诊疗工作及其相关基础研究和专科人才培养。

简介：<正>今年4月11日我刊召开在沪编委扩大会与创刊恳谈会,会议分别由我刊主编王正敏教授与眼耳鼻喉科医院院长张重华教授主持。上海医科大学副校长陈洁教授在讲话中要求编委会努力按"全、新、严、特"四字方针,切实把刊物办好。与会者除对本刊的创刊表示祝贺外,并对提高本刊质量与扩大订户纷纷出谋献策,有的在发言中表示要订阅本刊或增订本刊,长海医院耳鼻喉科主任李兆基教授当场预订本刊

简介：AIM:ToinvestigatetheexpressionsoftypeIcollagen,α2integrinandβ1integrinintheposteriorscleraofguineapigswithdefocusmyopiaandwhetherbasicfibroblastgrowthfactor(bFGF)injectioninhibitstheformationanddevelopmentofmyopiabyupregulatingtheexpressionoftypeIcollagen,α2integrinandβ1integrin.METHODS:After14daysoftreatment,therefractivestateandaxiallengthweremeasuredandthelevelsoftypeIcollagen,α2integrinandβ1integrinwereassayedintheposteriorscleraeofgroupsofguineapigsthatworeamonocular-7Dpolymethylmethacrylate(PMMA)lensorhad-7DlenswearfollowedbytheperibulbarinjectionofPhosphateBufferSolution(PBS)orbFGF.Theuntreatedfelloweyeservedasacontrol.Guineapigswithnotreatmentservedasnormalgroup.·RESULTS:Theresultsshowedthat14daysofmonoculardefocusincreasedaxialeyelengthandrefraction,whilebFGFdeliveryinhibitedthemmarkedly.Further,itwasalsofoundthatthemonocular-7DlenscoulddecreasethelevelsoftypeIcollagen,α2integrinandβ1integrinexpressions,while,unlikePBS,bFGFincreasedthemsignificantlyincomparisontocontralateralcontroleyesandnormaleyes.CONCLUSION:bFGFcanpreventtheformationanddevelopmentofdefocusmyopiabyupregulatingtheexpressionsoftypeIcollagen,α2integrinandβ1integrin.Takentogether,ourresultsdemonstratethatbFGFpromotesscleraremodelingtopreventmyopiainguineapigs.