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简介：本研究旨在分析鉴定中国人群HLA—B位点一个新等位基因。应用PCR-序列特异性寡核苷酸探针（PCR—SSOP）技术检测到一个与HLA—B＊35：03：01相关的未知基因，应用DNA序列分析技术鉴定并分析该基因与同源性最高的心等位基因的序列差异。结果表明，先证者HLA-B位点有1个等位基因的核苷酸序列与所有已知基因序列均不相同，与同源性最高的HLA-B＊35：03：01相比，第3外显子387位碱基由C→G，并导致相应的105位密码子编码的氨基酸由CCC变为CCG，编码的氨基酸没有改变，仍为苯丙氨酸。结论：被测样本含有HLA-B新等位基因，WHOHLA因子命名委员会将其正式命名为HLA-B＊35：03：07。

简介：AbstractBackground:Pancreatitis is a common disease of the digestive system. Acute pancreatitis is one of the most common reasons for gastrointestinal hospital admission, and chronic pancreatitis significantly reduces quality of life. However, national epidemiological data on pancreatitis in China are lacking. This study aimed to quantify the disease burden of pancreatitis in China from 1990 to 2019.Methods:This study was based on the Global Burden of Disease Study 2019 dataset. Age-standardized rates of incidence (ASIR), prevalence (ASPR), mortality (ASMR), and disability-adjusted life years (DALYs) were used to describe the disease burden of pancreatitis, and estimated annual percentage change (EAPC) was used to indicate the average change in age-standardized rates. We also described the trend of pancreatitis-related mortality and DALYs, which are attributable to alcohol use by age and sex.Results:From 1990 to 2019, the ASIR, ASPR, ASMR, and age-standardized DALYs of pancreatitis in China decreased by 10.90, 1.50, 0.49, and 15.54 per 100,000, respectively, with EAPCs of -1.35 (95% uncertainty interval [UI]: -1.67, -1.02) and -0.37 (95% UI: -0.43, -0.31), -2.01 (95% UI: -2.07, -1.94) and -2.32 (95% UI: -2.37, -2.28), respectively. Recently, the numbers of incident and prevalent cases have risen, with estimates of 380,018 (95% UI: 308,669-462,767) and 493,765 (95% UI: 416,705-578,675), respectively, in 2019. Among men, the disease burden of pancreatitis was more severe than among women, and with variances in the distribution among different age groups. Age-standardized DALYs caused by alcohol-related pancreatitis have gradually worsened in the past decade, accounting for 34.09% of the total in 2019.Conclusions:The disease burden of pancreatitis in China has declined in the past 30 years, but the exacerbation of population aging poses a challenge to prevention and control of pancreatitis. Alcohol use has gradually become an important factor in the disease burden of pancreatitis in recent years.

简介：摘要A recent epidemic of pneumonia cases in Wuhan China was caused by a novel coronavirus with strong infectivity, the 2019 novel coronavirus (2019-nCoV). The article provides the pulmonary rehabilitation (PR) methods in the principle of 4S (simple, safe, satisfy, save) for patients with pneumonia caused by the novel coronavirus, shows how to establish a ventilative and convectional PR environment to prevent the spread of virus through droplets, how to guide the patients to carry out PR, how to carry out respiratory muscle training, effective cough, expectoration, sneeze, general exercise, digestive function rehabilitation and psychological rehabilitation, and how to clean and disinfect the PR environment.

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简介：刚顺利做完一个活动，需要请客吃饭。这次和我一起吃饭的姑娘们，是我的礼仪小姐团队，她们多是我的学生，经常活跃在各大赛事和高端活动中。

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简介：AbstractTrauma is the leading cause of death in people under the age of 45 years, and it has gained wide attention from academics worldwide. Therefore, more and more studies have reported on trauma and related fields in recent decades. In 2019, Chinese Journal of Traumatology (CJTEE) published 69 articles covering traffic medicine, wound healing, bone trauma, emergency care, and other hot topics of traumatology. Here we reviewed a series of articles published in CJTEE on the topics mentioned above, try to give a brief introduction of progress in trauma field.

简介：《抗癌》杂志于1988年创刊,主管单位为上海市科学技术协会,主办单位为上海市抗癌协会。《抗癌》杂志坚持以读者为导向,架起读者与医院之间的桥梁,介绍抗癌防癌的科学知识,倡导健康的生活方式,宣传癌症患者战胜病魔的动人事迹.

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简介：摘要为掌握各专业医疗质量状况，从2015年开始，国家卫生健康委员会医政医管局质量处每年均组织撰写包括病理在内各专业的全国质量报告。根据2019年抽查的资料完整的3 643家医院病理科质控指标，统计分析如下：（1）全国平均每百张病床病理医师数量为0.55，约24.4%的病理科仅有1名病理医师，二级医院中，46.3%的病理科仅有1名病理医师。（2）全国平均每百张病床病理技术人员数为0.46；病理医师与技术人员的严重缺乏成为制约病理学发展的重要因素。（3）各医院术中快速病理诊断及时率、小活检标本诊断及时率及细胞学诊断及时率均在90%以上，同时发现由于工作量大、辅助检查项目多等因素，三级医院的诊断及时率低于二级医院。（4）免疫组织化学室间质控方面，三级公立医院、二级公立医院及民营医院病理科未参加室间质评的比例分别为35.8%、86.4%及78.2%。（5）开展分子病理检测的三级公立医院中，约76.2%的病理科未参加过室间质评。（6）细胞病理诊断质控符合率和术中快速诊断与石蜡诊断符合率均>96%；二级公立医院和民营医院术中快速诊断开展率和平均数量，远远低于三级公立医院。2019年，国家病理质控中心共举办了17个全国室间质评项目，参加的医院数量为2 431家次，专项培训人数12 286人次，发表分子检测指南1个。国家病理质控中心制定了省级病理质控中心工作量化考核方案，根据不完全统计，2019年全国32个省级病理质控中心共开展各种室间质评180项，覆盖医院4 373家次；督导检查下级医院754家，专项质控培训14 869人次。

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简介：AbstractObjective:Genital chlamydial infection is a globally common sexually transmitted infection caused by Chlamydia trachomatis. This study aimed to describe the epidemiological characteristics of the disease reported in China in 2019.Methods:Genital chlamydial infection cases were identified in 105 national sexually transmitted disease surveillance sites from the National Notifiable Infectious Disease Reporting System, which covers 31 provinces, autonomous regions, and municipalities in Chinese mainland. Data were collected and used to calculate the overall incidence, and the incidences per surveillance site, province, sex, and age group.Results:In 2019, there were 50,874 new cases of genital chlamydial infection reported in China, corresponding to an incidence of 55.32 cases per 100,000 population, and comprising a 9.98% increase from 2018 (50.30 cases per 100,000 population). The highest incidences of genital chlamydial infection occurred in Zhejiang, Guangdong province, Guangxi autonomous region, and Hainan province (average 137.49-233.37 cases per 100,000 population). The incidence of genital chlamydial infection was much higher in females than males, with a female-to-male ratio of 3.09 (84.55 per 100,000 population vs 27.35 per 100,000 population). The highest incidence of genital chlamydial infection was reported in the 20-24-year age group (184.70 cases per 100,000 population), followed by the 25-29-year age group (180.79 cases per 100,000) and 30-34-year age group (151.53 cases per 100,000 population). The highest proportion (68.30%) of genital chlamydial infection was reported from general hospitals, followed by maternal and child health hospitals (25.59%).Conclusion:The incidence rate of genital chlamydial infection in 2019 has an increase trend from 2018 and be a common sexually transmitted infection in China. The incidence is much higher in females than in males. Sexually active young adults are the highest risk population. There is substantial geographic diversity in incidence, with the highest incidence occurring in the southeast coastal areas with a developed economy. Epidemic of genital chlamydial infection in China should be concerned, and its surveillance needs to be improved.