简介:AbstractObjective:The aim of this work was to explore the feasibility of in vivo and non-invasive monitoring of deuterium/hydrogen (2H/1H) exchange at the metabolic level upon exposure to heavy water (2H2O).Methods:The healthy female mice were randomly assigned to two groups after day 0 when both mice received standard drinking water. The treated mouse was fed with 2H2O (80%, v/v) and the control mouse fed with standard drinking water (H2O) over next 13 days. Real-time mass spectrometric analysis of volatile metabolism emitted through breathing and the skin was performed on days 1, 2, 3, 10, 12, and 13. Animal experiment was approved by the Laboratory Animal Ethics Committee of Jinan University (approval No. 20161117163322) on October 29, 2021.Results:We observed a replacement of 1H by 2H in 52 mass spectral features (60 2H/1H isotopologue pairs) for the mouse fed with 2H2O, but not for the control mouse. These included pyruvic acid and lactic acid, lysine and methyl-lysine as well as short-chain fatty acids comprising acetic acid, propionic acid, butyric acid and valeric acid.Conclusion:Secondary electrospray ionization-high resolution mass spectrometry allows monitoring in vivo2H-incorporation of metabolites in a non-invasive and real-time setup and opens new opportunities to use 2H tracing to extend current metabolic studies, especially those with a focus on anaerobic glycolysis, lysine methylation and gut microbiome via monitoring of short-chain fatty acids.
简介:ThispaperstudiestheinfinitetimehorizonmixedH-two/H-infinitycontrolproblemfordescriptorsystemsusingNashgameapproach.Anecessary/sufficientconditionfortheexistenceofinfinitehorizonH-two/H-infinitycontrolispresentedintheformoftwocoupledalgebraicRiccatiequations,respectively.Finally,asuboptimalH-two/H-infinitycontrollerdesignisgivenbasedonaniterativelinearmatrixinequalityalgorithm.
简介:Thispaperreportstwolanthanidecomplexesofformula(C9H7)Ln(C8H8)·(THF)2whereLnisProrNd,C9H7isindenyl,andC8H8iscyclooctatetraene(COT).ThecomplexeswerepreparedbythereactionofLnCl3withK(C9H7)andK2(C8H8)inTHF.(C9H7)Pr(C8H8)·(THF)2crystallizesinTHFat-15℃inthemonoclinicspacegroupP21:withunitcelldimensionsa=8.446(0),b=10.083(2),c=13.407(3),β=105.48(1)°,V=1100.43(35)3,Dc=1.52g/cm3andZ=2.ThefinalRvalueis0.033,Rwvalueis0.030,respectively.In(C9H7)Pr(C8H8)·(THF)2afive-memberedringcentroidofC9H7,theC8H8ringcentroidandthetwooxygenatomsfromthetwoTHFmoleculesformadistortedtetrahedralgeometryaroundthemetal.
简介:Thesolidaddofthefirstprotonatedzincoborophosphate,(H3O)Zn(H2O)2BP2O8·H2O(1),wassoventothermallysyn-thesizedbythereactionofZn(NO3)2·6H2OandH3BO3withH3PO4inamixedsolvent,andstructurallycharacterizedbysingle-ystalX-raydiffractionanalysis.ItcrystallizesinthehexagonalP6122,a=0.9604(4)nm,c=1.5297(6)nm,V=1.2218(8)nm^3,Dc=2.921g/cm^3,Z=6,F(000)=1080,μ=3.495mm^-1.Thestmchwefeaturesthatthetetrahedra-te-trahedrahdlcesinterconnectedbyoctahedraandstronghydro-gembondinteractionsformathree-dimensionalframework.Theprotonatedwatermoleculesarelocatedatuniquepositions.othercharacterizationsbyIRandthermalanalysisarealsode-scribed.
简介:Weestablishseveralfundamentalidentities,includingrecurrencerelations,degreeelevationformulas,partitionofunityandMarsdenidentity,forquantumBernsteinbasesandquantumBeziercurves.WealsodeveloptwotermrecurrencerelationsforquantumBernsteinbasesandrecursiveevaluationalgorithmsforquantumBeziercurves.Ourproofsusestandardmathematicalinductionandotherelementarytechniques.
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简介:Theproblemoftherobustfaultdetectionfilterdesignfortime-varyingdelaysswitchedsystemsisconsideredintheframeworkofmixedH_-/H_∞.Firstly,theweightedH_∞performanceindexisutilizedastherobustnessperformance,andtheH_-indexisusedasthesensitivityperformanceforobtainingtherobustfaultdetectionfilter.ThenanovelmultipleLyapunov-Krasovskiifunctionisproposedforderivingsufficientexistenceconditionsoftherobustfaultdetectionfilterbasedontheaveragedwelltimetechnique.Byintroducingslackmatrixvariable,thecouplingbetweentheLyapunovmatrixandsystemmatrixisremoved,andtheconservatismofresultsisreduced.Basedontherobustfaultdetectionfilter,residualisgeneratedandevaluatedfordetectingfaults.Inaddition,theresultsofthispaperaredependentontimedelays,andrepresentedintheformoflinearmatrixinequalities.Finally,thesimulationexampleverifiestheeffectivenessoftheproposedmethod.
简介:目的探讨老年高血压伴有血同型半胱氨酸增高(H型高血压)患者肾功能受损情况。方法将60岁以上原发性高血压263例患者,按血同型半胱氨酸的检验值分为:非H型高血压组、H型高血压1组、H型高血压2组,测定3组病例的24h尿微量蛋白,将3组病例的24h尿微量蛋白进行比较。结果H型高血压2组患者血同型半胱氨酸(24.83±4.00)μmol/L虷型高血压1组患者血同型半胱氨酸(15.73±3.84)μmol/L较非H型高血压组(6.14±3.58)μmol/L显著增高(P〈0.01);H型高血压2组患者24h尿微量蛋白(24.83±4.00)mg/L较H型高血压1组患者24h尿微量蛋白(15.73±3.84)mg/L亦显著增高(P〈0.01)。结论老年H型高血压患者更易发生肾脏损害。