简介：AnewclassofcrosslinkingpolyphosphatesweresynthesizedandcharacterizedbyIR^1HNMR,^31PNMRspectroscopyaswellaselementalanalysis.InvitrodegradationofthepolyphosphatesobtainedandthereleaseofantineoplasticdrugMethotrexate(MTX)andcontraceptiveLevonorgestrel(LNG)byusingthesepolymersasmatrixwerestudied.ZeroorderreleaseratewasobservedinthecaseofLNGrelease.

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简介：Thispaperreportsthesynthesisofaseriesofpolysiloxanesbearinglongsidechainmeltedatlowtemperature.Thedrug(LNG)releasingpropertiesofthesiciconerubberfilmscontainingthesepolyorganosiloxaneswerestudied.Thereleaseratesofthedrugincreaseasthetemperatureriseupabovethemeltingtemperatureofthesepolyorganosiloxanes.

简介：Wepresentherethedevelopmentofcholesterol(Chol)-modifieddendrimersystemfortargetedchemotherapyoffolate(FA)receptor-expressingcancercells.Inourstudy,poly(amidoamine)(PAMAM)dendrimersofgeneration5(G5)werefunctionalizedstepby-stepwithChol,fluoresceinisothiocyanate(FI),andFAviaapoly(ethyleneglycol)(PEG)spacer(PEG-FA),andthenacetamidetoshieldtheirremainingsurfaceamines.ThesynthesizedG5.NHAc-Chol-FI-PEG-FA(forshort,G5-CFPF)dendrimerswereutilizedtoencapsulate10-hydroxycamptothecin(HCP),ahydrophobicanticancerdrug.WefindthateachG5-CFPFdendrimercanencapsulate13.8HCPmolecules.ThecomplexesshowaslowerreleaseprofilesofHCPinapH-dependentmannerthanthecontrolcomplexesformedusingthesamedendrimerswithoutCholunderthesameconditions.ThankstothetargetingroleplayedbyFA,thecomplexesdisplayaspecificinhibitionefficacytoFAreceptor-expressingcervicalcancercells.ThedesignedChol-modifieddendrimersmaybeadoptedasapromisingcarrierforapplicationintargetedcancertherapy.

简介：Inthispaper,itwasinvestigatedthattheeffectofparameterssuchastheionicstrength,pH,counter-iontypeofreleasemedium,particlesize,andcrosslinkageofcationexchangeresinonthereleaseofmodeldrugpseudoephedrinehydrochloride(PE)fromuncoateddrug-resincomplex.Thedrug-resincomplexwaspreparedbythereactionofPEwithstronglyacidiccationexchangeresin(001×4,001×7,001×14).TheresultshowedthattheloadingofPEincreasedwiththeincreaseoftemperatures.ThereleaseofPEfromdrug-resincomplexat37℃wasmonitoredinvitro.Fromtheexperiments,itwasfoundthatthereleaserateofPEdependsonthepH,compositionofthereleasingmedia,increasedatlowerpHmediaorwithincreaseofionicstrengthofmedia.Moreover,thereleaserateofPEwasinverselyproportionaltothecross-linkageandparticlesizeofthecationexchangeresin.