简介：摘要：肠黏膜是人体中一道天然的预防细菌的屏障，它不仅可以保护人体胃肠道受损，还能防止病毒等有害细菌进入血液中。是人体必不可少的保护屏障。随着人们生活水平的提高，饮食规律及起居不规范，如暴饮暴食、熬夜、食物单一，或不良嗜好，如吸烟，喝酒，经常食用熏烤类食物及饮用刺激性饮料，这些都会紊乱胃肠道菌群失调、破坏酸碱平衡，进而引起胃肠道粘膜损伤。胃肠道粘膜损伤不仅会影响人体的免疫机制，还会引起胃肠道溃疡，胃肠道糜烂，胃肠道出血等一系列疾病。严重者还会引起胃肠道恶性肿瘤。

简介：ExposureofnaivemurineCD4^+TlymphocytestosuperantigensuchasstaphylococcalenterotoxinB(SEB)inducesastrongproliferativeresponse.ProlongedexposureorsubsequentrestimulationoftherespondingTcellpopulationwithSEBleadstotheapoptoticeventsofactivation-inducedcelldeath(AICD).ThesignalingmechanismresponsiblefortheAICDisatargetofintensiveinvestigation.However,theprecisedownstreamsignahngpathwaysofSEB-inducedAICDremainsunclear.Ourresultshereshowthatthesequentialactivationofcaspase-1/ICE-hkeandcaspase-3/CPP32-hkecysteineproteasesprobablyplaysaroleinthesignalingtransductionofSEB-inducedAICD,butcaspase-3/CPP32-hkeproteasesactivationdoesnotdependoncaspase-1-likeproteasesactivation.HerbimycinA,aspecificinhibitorofproteintyresinekinases,inhibitcaspase-3/CPP32-1ikecysteineproteasesactivation.However,itdoesnotpreventDNAfragmentationofCD4^+TcellsapoptosisinducedbySEB.TheseresultsindicatethatproteintyrosinekinasespathwayisprobablyinvolvedinthesignalingtransductionofCD4^+TcellsapoptosisinducedbySEBand“crosstalks”withthepathwayofcaspase-3/CPP32-1ikeproteasesactivation.