简介：ShriDeependraSinghappointedtheChairmanandManagingDirectorofIRELShriDeependraSinghhastakenoverasChairmanandManagingDirectorofIndianRareEarthsLtd.(IREL),acentralpublicsectorundertakingundertheaegisofDepartmentofAtomicEnergy,Govt.ofIndiaw.e.f.1stDecember,2015.Priortothis,hewasDirector(Marketing)inIndianRareEarthsLtd.since

简介：Thefocusofthisyear'sconferenceisGlobalExtremeEvents,characterizedaslarge-scaleclimaticeffectsthathavebeenincreasinginmagnitudeandfrequency.Prof.SinyanShen,ChairmanoftheGWInternationalProgramCommittee,hasbeenleadingtheworldonGlobalExtremeEventsandEmergencyResponse.InthelongtermclimatechangewillcausetheEarthtotransittoanotherequilibriumstatethroughmanyoscillationsinclimaticpattern.Globalwarmingcausesextremeeventsandbadweatherinthenearterm.Theimmediate

简介：AbstractBackground:The prevalence rates of freezing of gait (FOG) in Parkinson’s disease (PD) vary widely, ranging from 14.0 to 55.1%. Our aim is to calculate the overall prevalence of FOG in all PD patients with different disease durations and severities.Methods:Using Medline/PubMed/Embase, we carried out a systematic literature search for studies reporting the PD and clinically relevant FOG.Results:After primary screening, a total of 35 studies were identified and further analyzed for inclusion into the analysis, and 29 studies fulfilled the quality criteria and included in this meta-analysis. The overall prevalence of FOG in PD was 39.9% (95% CI 35.3-44.5%). The FOG identified by the freezing of gait questionnaire item 3 may be more prevalent (43.8%, 95% CI 38.5-49.1%) than the FOG identified by the Unified Parkinson’s Disease Rating Scale item 14 (36.0%, 95% CI 29.0-43.1%). Disease duration and severity are both the clinical features associated with the FOG. The highest FOG prevalence rate in PD patients was seen in patients with disease durations ≥ 10 years, at 70.8%, followed that of PD patients with disease durations ≥ 5 years (53.3%), and PD patients with disease durations < 5 years (22.4%). FOG presented in 28.4% of PD patients with Hoehn and Yahr staging (H&Y) score ≤ 2.5, and in 68.4% of PD patients with H&Y score ≥ 2.5.Conclusion:This meta-analysis confirms that the prevalence of FOG in PD is considerable, and highlights the need for accurate identification of FOG in PD.

简介：AbstractBackgroundSince early December 2019, the 2019 novel coronavirus disease (COVID-19) has caused pneumonia epidemic in Wuhan, Hubei province of China. This study aimed to investigate the factors affecting the progression of pneumonia in COVID-19 patients. Associated results will be used to evaluate the prognosis and to find the optimal treatment regimens for COVID-19 pneumonia.MethodsPatients tested positive for the COVID-19 based on nucleic acid detection were included in this study. Patients were admitted to 3 tertiary hospitals in Wuhan between December 30, 2019, and January 15, 2020. Individual data, laboratory indices, imaging characteristics, and clinical data were collected, and statistical analysis was performed. Based on clinical typing results, the patients were divided into a progression group or an improvement/stabilization group. Continuous variables were analyzed using independent samples t-test or Mann-Whitney U test. Categorical variables were analyzed using Chi-squared test or Fisher’s exact test. Logistic regression analysis was performed to explore the risk factors for disease progression.ResultsSeventy-eight patients with COVID-19-induced pneumonia met the inclusion criteria and were included in this study. Efficacy evaluation at 2 weeks after hospitalization indicated that 11 patients (14.1%) had deteriorated, and 67 patients (85.9%) had improved/stabilized. The patients in the progression group were significantly older than those in the disease improvement/stabilization group (66 [51, 70] vs. 37 [32, 41] years, U= 4.932, P= 0.001). The progression group had a significantly higher proportion of patients with a history of smoking than the improvement/stabilization group (27.3% vs. 3.0%, χ2 = 9.291, P = 0.018). For all the 78 patients, fever was the most common initial symptom, and the maximum body temperature at admission was significantly higher in the progression group than in the improvement/stabilization group (38.2 [37.8, 38.6] vs. 37.5 [37.0, 38.4]°C, U= 2.057, P= 0.027). Moreover, the proportion of patients with respiratory failure (54.5% vs. 20.9%, χ2 = 5.611, P = 0.028) and respiratory rate (34 [18, 48] vs. 24 [16, 60] breaths/min, U= 4.030, P = 0.004) were significantly higher in the progression group than in the improvement/stabilization group. C-reactive protein was significantly elevated in the progression group compared to the improvement/stabilization group (38.9 [14.3, 64.8] vs. 10.6 [1.9, 33.1] mg/L, U= 1.315, P= 0.024). Albumin was significantly lower in the progression group than in the improvement/stabilization group (36.62 ± 6.60 vs. 41.27 ± 4.55 g/L, U = 2.843, P = 0.006). Patients in the progression group were more likely to receive high-level respiratory support than in the improvement/stabilization group (χ2 = 16.01, P = 0.001). Multivariate logistic analysis indicated that age (odds ratio [OR], 8.546; 95% confidence interval [CI]: 1.628-44.864; P = 0.011), history of smoking (OR, 14.285; 95% CI: 1.577-25.000; P= 0.018), maximum body temperature at admission (OR, 8.999; 95% CI: 1.036-78.147, P= 0.046), respiratory failure (OR, 8.772, 95% CI: 1.942-40.000; P = 0.016), albumin (OR, 7.353, 95% CI: 1.098-50.000; P = 0.003), and C-reactive protein (OR, 10.530; 95% CI: 1.224-34.701, P = 0.028) were risk factors for disease progression.ConclusionsSeveral factors that led to the progression of COVID-19 pneumonia were identified, including age, history of smoking, maximum body temperature at admission, respiratory failure, albumin, and C-reactive protein. These results can be used to further enhance the ability of management of COVID-19 pneumonia.

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简介：Paget'sdiseaseofboneisafocaldisorderofboneremodellingcausedbyabnormallyincreasedosteoclast-mediatedboneresorption.qtleaffectedboneschangeinshaw,sizeanddirection,whiletherestoftheskeletonremainsnormal.TheclinicalconsequencesofthediseasewerefirstdescribedbySirJanlesPagetin1876(Figure1).

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简介：Agluten-freedietiscurrentlytheonlyeffectivemeansoftreatingindividualswithceliacdisease.Suchadietenablesceliacpatientstocontroltheirsymptomsandavoidvariouscomplicationsassociatedwiththiscondition.However,whilethequalityofgluten-freefoodshassignificantlyimprovedduringrecentdecades,maintenanceofagluten-freedietdoesnotnecessarilyensureadequatenutritionalintake.Becauseoatsareanimportantsourceofproteins,lipids,vitamins,minerals,andfibre,theirinclusioninagluten-freedietmightimprovethenutritionalstatusofaceliacpatient.AlthoughoatsareincludedinthelistofglutenfreeingredientsspecifiedinEuropeanregulations,theirsafetywhenconsumedbyceliacpatientsremainsdebatable.Somestudiesclaimthatpureoatsaresafeformostceliacpeople,andcontaminationwithothercerealsourcesisthemainproblemfacingpeoplewiththisdisease.However,itisnecessarytoconsiderthatoatsincludemanyvarieties,containingvariousaminoacidsequencesandshowingdifferentimmunoreactivitiesassociatedwithtoxicprolamins.Asaresult,severalstudieshaveshownthattheimmunogenicityofoatsvariesdependingonthecultivarconsumed.Thus,itisessentialtothoroughlystudythevarietyofoatsusedinafoodingredientbeforeincludingitinagluten-freediet.

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简介：TheJanuskinase-signaltransducersandactivatorsoftranscription(JAK-STAT)signalingpathway,activatedbymorethan50cytokinesorgrowthfactors,playscriticalrolesinawidevarietyofcellularfunctionsinthehematopoietic,immune,neuronalandhepaticsystems.Intheliver,thissignalingpathway,activatedbymorethan20cytokines,growthfactors,hormones,andhepatitisviralproteins,playscriticalrolesinantiviraldefense,acutephaseresponse,hepaticinjury,repair,inflammation,transformation,andhepatitis.ThisarticlereviewsthebiologicalsignificanceofSTAT1,2,3,4,5,6inhepaticfunctionsanddiseases.Cellular&MolecularImmunology.2005;2(2):92-100.

简介：Cardiovasculardisease(CVD)istheleadingcauseofdeathworldwide.ThisarticlefocusesoncurrentguidelinesfortheprimarypreventionofCVDandaddressesmanagementofkeyriskfactors.Dietarymodification,weightloss,exercise,andtobaccousecessationarespecificareaswherefocusedeffortscansuccessfullyreduceCVDriskonbothanindividualandasocietallevel.Specificareasrequiringmanagementincludedyslipidemia,hypertension,physicalactivity,diabetes,aspirinuse,andalcoholintake.Thesepreventiveeffortshavemajorpublichealthimplications.Astheglobalpopulationcontinuestogrow,healthcareexpenditureswillalsorise,withthepotentialtoeventuallyoverwhelmthehealthcaresystem.ThereforeitisimperativetoapplyourcollectiveeffortsonCVDpreventiontoimprovethecardiovascularhealthofindividuals,communities,andnations.

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简介：<正>OneofthemandatesItriedtoembracewhenIwaspresidentoftheInternationalSocietyofBiomechanics(2007-2009)wastofoster,encourage,andbringtothelimelight,theresearchactivitiesfromcountriesthatwereunderrepresentedinternationally.Irealizedthatsuchunderrepresentationwasoftentheresultofbarriersbetweenscientificcommunitiesthathadevolvedhistorically,basedonbackground,language,scientificmethod,financialsupportetc.,barriersthatcouldeasilybeovercomebypersonalcontacts,acknowledgementof

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简介：IN1993,Dr.andMrs.LeonwerenamedCitizensoftheYearbytheJoplinChamberofCommerce.Dr.JulioS.LeonhasbeenpresidentofMissouriSouthernStateUniversitysince1982.HisfocusisonmaintainingMSSUasastrongpresenceinthecommunityandprovidingeducationforstudentsfromaroundtheglobe.Mrs.VivianNgLeonpresidesovertheprestigiousMissouriSouthernInterna-

简介：一个灵活起床人的机械表演是比处于强烈环境条件的另外的起床人更突出的。基于lumped团方法，灵活起床人配置纳入了漂浮的生产存储的一个陡峭的波浪并且(FPSO)卸载被用于全球分析以便获得灵活起床人的静态、动态的行为。起床人在每结束与一个节点被划分成一系列笔直地无团的线片断。当团，重量，和快活都是到节点的lumped时，仅仅线的轴、扭力的性质被建模。四不同快活模块长度被做了表明模式选择的重要性，以便证实最佳快活模块长度。在灵活起床人不对海洋水流很敏感的敏感学习表演的结果，和快活模块能减少Von协定压力并且改进灵活起床人的机械表演。更短的快活模块长度能减少起床人在快活模块长度的一个特定的范围的有效紧张当另外的参数是时，常数，而是它能也增加起床人的最大的弯曲。作为结果，各种起床人表演应该被考虑以便选择最适当的快活模块长度。

简介：Whenandhowdoestheultra-right-wingterrorismperiodcloseastheirmeaninpoliticswiththegoalofdeterrenceandthedestructionofthecapitalistorder?Whydoesthe“Arabianjihad”shiftitsprioritiesfromthe“closeenemy”tothe“farenemy”?Whydidterroristviolenceappearmoreoften,inthelastcoupleofdecades,inthecountrieswhereMuslimsarethemajority,orwhyaretheperpetrators,intermsofterroristacts,mostlyMuslims?Thesearethequestionswhichareintheacademicdiscussioncentreandanalysisofourpaper.Thepaperidentifiesthecausesanddiscussesthe“us”and“them”polarization.Thegoalistoexplainwhatisbehindtheseparolesthroughtheanalysisofworld’sauthors:“Waragainstterrorism”,“Unityofanation”,and“Thejustwar”.Fromatheoreticalandempiricalpointofview,emphasizingoftheIslamiccomponentinterrorismisunfairatleast.Weusedqualitativeresearchmethods,includingthedeskresearch,toobtainnecessarydatatogiveanswersonourresearchquestions.