简介:摘要目的探讨乙肝病毒前S1抗原(Pre-S1Ag)与HBV血清标志物(HBVM)同步检测的临床价值。方法对确诊的380例乙肝病例空腹抽血,采用ELISA法及HAMILTN全自动酶联免疫分析仪同步检测Pre-S1Ag与HBVM(HBsAg、抗-HBs、HBeAg、抗-HBe、抗-HBc),并对结果进行比较分析。统计学处理采用χ2检验。结果统计显示PreS1Ag的检出率HBsAg、HBeAg、HBcAb阳性组(78.8%)明显高于HBsAg、HBeAb、HBcAb阳性组(41.6%),差异有显著性(χ2=21.04,P<0.01);HBsAg、HBeAg阳性组PreS1Ag阳性率(79.3%)明显高于HBsAg、HBcAb阳性组(25.3%),提示HBeAg阳性组中PreS1Ag阳性率明显高于HBeAg阴组,差异有显著性(χ2=21.49,P<0.01);提示PreS1Ag是一个与HBeAg同时存在的较好指标。结论前S1抗原与病毒复制有关,与HBeAg具有一致性;与HBVM同步检测,可减少和避免HBeAg系统发生变异所致的假阴性对临床的误导。
简介:AbstractTotal pancreatectomy with islet autotransplantation (TPIAT) is an effective treatment option for non-diabetic patients with intractable chronic pancreatitis. The outcome and potential benefits for pre-diabetic and diabetic patients are less well established. Thirty-four patients underwent TPIAT were retrospectively divided into 3 groups according to pre-operative glycemic control: diabetes mellitus (DM) (n=5, 15%), pre-DM (n=11, 32%) and non-DM (n=18, 54%). Pre-operative fasting c-peptide was detectable and similar in all 3 groups. Islet yield in the DM group was comparable to pre-DM and non-DM groups (median islet equivalents [IEQ] was 191,800, 111,800, and 232,000 IEQ, respectively). Patients received islet mass of over the target level of 2000 IEQ/kg in pre-DM and DM at lower but clinically meaningful rates compared to the non-DM group: 45% (5/11) and 60% (3/5) for a combined 50% (8/16) rate, respectively, compared to 83% (15/18) for the non-DM group. At 1 year, fasting c-peptide and HbA1c did not differ between DM and pre-DM groups but c-peptide was significantly higher in non-DM. Islet transplantation failed (negative c-peptide) only in 1 patient. Preoperatively, all patients experienced pancreatic pain with daily opioid dependence in 60% to 70%. Pancreatic-type pain gradually subsided completely in all groups with no differences in other painful somatic symptoms. Diabetic patients with measurable pre-operative c-peptide can achieve similar benefit from TPIAT, with comparable outcomes to pre-diabetic and non-diabetic patients including pain relief and the metabolic benefit of transplanted islets. Not surprisingly, endocrine outcomes for diabetic and prediabetics patients are substantially worse than in those with normal pre-operative glucose control.
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简介:Objective:Totestforpre-attentiveauditorydiscriminationskillsinIndianclassicalvocalmusiciansandnon-musicians.Design:Mismatchnegativity(MMN)wasrecordedtotestforpre-attentiveauditorydiscriminationskillswithapairofstimuliof/1000Hz/and/1100Hz/,with/1000Hz/asthefrequentstimulusand/1100Hz/astheinfrequentstimulus.Onset,offsetandpeaklatenciesweretheconsideredlatencyparameters,whereaspeakamplitudeandareaunderthecurvewereconsideredforamplitudeanalysis.Studysample:Exactly50participants,outofwhichtheexperimentalgrouphad25adultIndianclassicalvocalmusiciansand25age-matchednon-musiciansservedasthecontrolgroup,wereincludedinthestudy.ExperimentalgroupparticipantshadaminimumprofessionalmusicexperienceinIndianclassicvocalmusicof10years.However,controlgroupparticipantsdidnothaveanyformaltraininginmusic.Results:Descriptivestatisticsshowedbetterwaveformmorphologyintheexperimentalgroupascomparedtothecontrol.MANOVAshowedsignificantlybetteronsetlatency,peakamplitudeandareaunderthecurveintheexperimentalgroupbutnosignificantdifferenceintheoffsetandpeaklatenciesbetweenthetwogroups.Conclusion:Thepresentstudyprobablypointstowardstheenhancementofpre-attentiveauditorydiscriminationskillsinIndianclassicalvocalmusicianscomparedtonon-musicians.ItindicatesthatIndianclassicalmusicaltrainingenhancespre-attentiveauditorydiscriminationskillsinmusicians,leadingtohigherpeakamplitudeandagreaterareaunderthecurvecomparedtonon-musicians.
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简介:改进集中的能力预先叠时间移植允许想象的节反映结构的特征,深度,和接口形状,它是为起始的深度迁居速度模型的准备的关键步。传统的对称的旅行时间方程基于一个分层的模型的假设被导出。完成与强壮的侧面的变化集中在媒介的需要的效果是困难的。非对称的旅行时间方程基于谎言代数学和一个伪differential操作符包含能甚至在强烈侧面的可变媒介并且也改进集中的能力的侧面的速度衍生物为相对振幅保藏的重量系数的计算精确。与对称的方法相比,非对称的方法是更有效的。在这篇论文,我们描述几关键步非对称预先叠旅行时间计算和现在的一些测试用合成、真实的数据结果。
简介:MidwivesintheWellingtonregionhavenotedthatwomenreceivingprebirthacupunctureconsistentlyexperiencemoreefficientlabours.Midwivesreportthatthelengthoflabourisreduced,particularlyinprimigravidwomen,withareductioninmedicalinterventionrequired.Thispaperwillevaluateanauditof15midwiveswhohavecompletedaspecializedtrainingprogrammeinacupunctureandcurrentlyofferprebirthacupunctureasanadjuncttotheirmidwiferypractice.