简介:AbstractObjective:The aim of this work was to explore the feasibility of in vivo and non-invasive monitoring of deuterium/hydrogen (2H/1H) exchange at the metabolic level upon exposure to heavy water (2H2O).Methods:The healthy female mice were randomly assigned to two groups after day 0 when both mice received standard drinking water. The treated mouse was fed with 2H2O (80%, v/v) and the control mouse fed with standard drinking water (H2O) over next 13 days. Real-time mass spectrometric analysis of volatile metabolism emitted through breathing and the skin was performed on days 1, 2, 3, 10, 12, and 13. Animal experiment was approved by the Laboratory Animal Ethics Committee of Jinan University (approval No. 20161117163322) on October 29, 2021.Results:We observed a replacement of 1H by 2H in 52 mass spectral features (60 2H/1H isotopologue pairs) for the mouse fed with 2H2O, but not for the control mouse. These included pyruvic acid and lactic acid, lysine and methyl-lysine as well as short-chain fatty acids comprising acetic acid, propionic acid, butyric acid and valeric acid.Conclusion:Secondary electrospray ionization-high resolution mass spectrometry allows monitoring in vivo2H-incorporation of metabolites in a non-invasive and real-time setup and opens new opportunities to use 2H tracing to extend current metabolic studies, especially those with a focus on anaerobic glycolysis, lysine methylation and gut microbiome via monitoring of short-chain fatty acids.
简介:ThispaperstudiestheinfinitetimehorizonmixedH-two/H-infinitycontrolproblemfordescriptorsystemsusingNashgameapproach.Anecessary/sufficientconditionfortheexistenceofinfinitehorizonH-two/H-infinitycontrolispresentedintheformoftwocoupledalgebraicRiccatiequations,respectively.Finally,asuboptimalH-two/H-infinitycontrollerdesignisgivenbasedonaniterativelinearmatrixinequalityalgorithm.
简介:Thispaperreportstwolanthanidecomplexesofformula(C9H7)Ln(C8H8)·(THF)2whereLnisProrNd,C9H7isindenyl,andC8H8iscyclooctatetraene(COT).ThecomplexeswerepreparedbythereactionofLnCl3withK(C9H7)andK2(C8H8)inTHF.(C9H7)Pr(C8H8)·(THF)2crystallizesinTHFat-15℃inthemonoclinicspacegroupP21:withunitcelldimensionsa=8.446(0),b=10.083(2),c=13.407(3),β=105.48(1)°,V=1100.43(35)3,Dc=1.52g/cm3andZ=2.ThefinalRvalueis0.033,Rwvalueis0.030,respectively.In(C9H7)Pr(C8H8)·(THF)2afive-memberedringcentroidofC9H7,theC8H8ringcentroidandthetwooxygenatomsfromthetwoTHFmoleculesformadistortedtetrahedralgeometryaroundthemetal.
简介:Thesolidaddofthefirstprotonatedzincoborophosphate,(H3O)Zn(H2O)2BP2O8·H2O(1),wassoventothermallysyn-thesizedbythereactionofZn(NO3)2·6H2OandH3BO3withH3PO4inamixedsolvent,andstructurallycharacterizedbysingle-ystalX-raydiffractionanalysis.ItcrystallizesinthehexagonalP6122,a=0.9604(4)nm,c=1.5297(6)nm,V=1.2218(8)nm^3,Dc=2.921g/cm^3,Z=6,F(000)=1080,μ=3.495mm^-1.Thestmchwefeaturesthatthetetrahedra-te-trahedrahdlcesinterconnectedbyoctahedraandstronghydro-gembondinteractionsformathree-dimensionalframework.Theprotonatedwatermoleculesarelocatedatuniquepositions.othercharacterizationsbyIRandthermalanalysisarealsode-scribed.
简介:摘要目的比较卵巢上皮细胞癌应用TP方案和PC方案的效果。方法选择我院2003年6月-2007年6月62例卵巢上皮细胞癌患者随机分为两组,TP组31例患者采用TP(紫杉醇+顺铂)方案,PC组31例患者采用PC(顺铂+环磷酰胺)方案,所有患者均随访6-60个月,比较两种方案的效果。结果比较两组患者近期效果,TP组完全缓解12例,部分缓解13例,总有效率为80.65%;PC组完全缓解6例,部分缓解9例,总有效率为48.39%;比较两组远期疗效,TP组1、2、3、5年生存率分别为61.29%、45.16%、29.03%、12.9%,PC组1、2、3、5年生存率分别为48.39%、29.03%、16.13%、0,两组比较差异具有显著性,有统计学意义P<0.05。两组毒副反应主要表现为白细胞下降、骨骼抑制、恶心、呕吐等消化道反应及神经毒性等,两组不良反应比较差异无显著性,无统计学意义P>0.05。结论TP方案无论近期效果及远期疗效均优于PC方案,且不会增加毒副反应,可作为卵巢上皮细胞癌术后化疗的首选。
简介:目的观察甲地孕酮在治疗晚期非小细胞肺癌(NSCLC)化疗中的辅助治疗效果。方法60例晚期NSCLE患者,随机分为治疗组与对照组,治疗组30例给予甲地孕酮联合TP方案[TAX(紫杉醇)+DDP(顺铂)]治疗;对照组30例行单纯TP方案化疗。两组患者均以21天为1个周期,所有患者至少接受2周期治疗后评价疗效。观察两组患者的客观疗效、生活质量、化疗毒副反应的变化情况及甲地孕酮的不良反应。结果两组患者客观疗效(CR+PR)分别为50%及46.7%,无显著性差异(P〉0.05);治疗组患者在食欲改善、体重增加和提高Kamofsky评分,以及在保护骨髓功能和减轻消化道反应方面均优于对照组,差异非常显著(P〈0.01),未见甲地孕酮引起的不良反应。结论甲地孕酮联合TP方案和单纯TP方案治疗晚期NSCLC的客观疗效无明显差异,但前者毒副反应小,患者生活质量明显改善。
简介:摘要本人对29例TRUST阳性(效价≥164),但同时TP-ELISA检测阴性的病人血清经倍比稀释后,26例14后呈阳性反应,1例18后呈阳性反应,2例116后呈阳性反应.同时经TPPA检测均阳性。因此对于高滴度的TRUST阳性血清作TP-ELISA检测阴性时应作相应的稀释,避免因前带现象而呈假阴性。
简介:摘要目的探讨热疗联合TP(紫杉醇联合顺铂)方案治疗中晚期卵巢癌的疗效方法选取本院2014年6月至2015年6月收治的67病例中晚期卵巢癌患者作为研究对象,按照随机数表法分为观察组(n=33)及对照组(n=34),两组患者均给予TP方案化疗,观察组患者在此基础上加用热疗,比较两组近期疗效、生活质量改善状况及不良反应发生情况。结果观察组患者治疗有效率为72.7%(24/33),对照组为52.9%(18/34),观察组近期疗效显著由于对照组(P<0.05)。观察组和对照组的生活质量改善率分别为63.6%和35.3%,差异有显著意义(P<0.05)。观察组患者白细胞减少、恶心、呕吐及过敏反应的发生率明显低于对照组(P<0.05),两组患者肝损伤发生率比较差异无显著性(P>0.05)。结论热疗联合TP方案在中晚期卵巢癌的治疗中效果较佳,在提高患者近期疗效的同时还有助于改善患者生活质量和降低部分不良反应。远期预后以及影响机制仍有待进一步研究证实。
简介:摘要:目的 本文旨在分析人类免疫缺陷病毒(HIV)感染者114例乙型肝炎病毒(HBV)、丙型肝炎病毒(HCV)及梅毒螺旋体(TP)检测结果。方法 随机入选我县HIV治疗点收治于2019年7月21日/2020年12月
简介:摘要目的了解在我院美沙酮社区门诊吸毒人群艾滋病抗体(HIV)、丙型肝炎抗体(HCV)和梅毒抗体(TP)感染状况,及维持治疗期间新发生的感染状况。初步评价美沙酮门诊维持治疗,对控制HIV、HCV、TP感染作用。方法对参加维持治疗的海洛因依赖者进行HIV、HCV和TP血清学检测。并每半年进行一次HIV、HCV和TPF复检,对相关数据进行分析。结果参加维持治疗前吸毒人群HIV、HCV和TP感染率分别为4.81%%、71.12%、7.66%;参加维持治疗后吸毒人员中,HIV、HCV和TP感染检出阳性率,随着维持治疗时间延长逐年下降。结论积极开展美沙酮门诊维持治疗等针对性的干预措施。防止这些传染性疾病的进一步蔓延,对控制HIV、HCV、TP感染有效。
简介:Weestablishseveralfundamentalidentities,includingrecurrencerelations,degreeelevationformulas,partitionofunityandMarsdenidentity,forquantumBernsteinbasesandquantumBeziercurves.WealsodeveloptwotermrecurrencerelationsforquantumBernsteinbasesandrecursiveevaluationalgorithmsforquantumBeziercurves.Ourproofsusestandardmathematicalinductionandotherelementarytechniques.