简介：　　【摘 要】目的：探究他克莫司与环磷酰胺治疗狼疮性肾炎的的效果和用药不良反应率。方法：纳入观察对象 40例（均确诊为狼疮性肾炎）进行实验研究，研究时间从 2015年 3月直至 2019年 5月。采用随机分组法，将观察对象分为甲乙两组，甲组 20例患儿使用他克莫司治疗，乙组 20例患儿采取环磷酰胺治疗。观察对比两组患儿治疗效果、不良反应发生情况。结果：甲组中 1例患儿疗效不明显，另外 19例均有改善，总有效率 95%;乙组中 5例疗效不明显， 1例病情恶化，另外 14例病情改善，总有效率 70%，两组间进行比较后得到 P<0.05。治疗后随访观察到，甲组患儿 1例出现尿痛的不良反应，乙组中有 6例，两组不良反应发生率的差异显著（ P<0.05）。结论：狼疮性肾炎患儿在治疗过程中可应用他克莫司与环磷酰胺进行治疗，对比发现，他克莫司可以明显提升治疗的有效率，并且控制了患儿不良反应的出现，治疗安全性得到保障，临床应用效果理想，值得推广。  　　【关键词】他克莫司 ;环磷酰胺 ;狼疮性肾炎 ;效果 ;不良反应率  　 [Abstract] Objective: To explore the effect and adverse reaction rate of tacrolimus and cyclophosphamide in the treatment of lupus nephritis. Methods: 40 patients (all diagnosed as lupus nephritis) were included in the experimental study. The study period was from March 2015 to may 2019. The observation objects were randomly divided into two groups, group A (20 cases) was treated with tacrolimus, and group B (20 cases) was treated with cyclophosphamide. The treatment effect and adverse reactions of the two groups were observed and compared. Results: in group A, the curative effect of 1 case was not obvious, the other 19 cases were improved, the total effective rate was 95%; in group B, the curative effect was not obvious in 5 cases, 1 case was deteriorated, the other 14 cases were improved, the total effective rate was 70%, the comparison between the two groups showed that P < 0.05. After treatment, 1 case of adverse reactions occurred in group A and 6 cases in group B. There was a significant difference in the incidence of adverse reactions between the two groups (P < 0.05). Conclusion: tacrolimus and cyclophosphamide can be used in the treatment of children with lupus nephritis. Compared with cyclophosphamide, tacrolimus can significantly improve the efficiency of treatment, and control the occurrence of adverse reactions in children. The safety of treatment is guaranteed and the clinical application effect is ideal, which is worthy of promotion.

简介：　　 [摘要 ] 目的 观察慢性阻塞性肺疾病患者采取抗氧化剂治疗对营养状态、抗氧化指标的影响。 方法 采用随机数字表法将方便选取该院 2018年 3月— 2020年 3月收入的 110例慢性阻塞性肺疾病患者分为采取常规治疗的对照组及加用抗氧化剂治疗的观察组各 55例，对两组营养状态、抗氧化状态、不良反应发生率进行比较。结果 治疗后观察组体质量指数（ 24.91±1.01） kg/m2、白蛋白（ 43.25±1.25） g/L、球蛋白（ 30.30±1.35） g/L、总抗氧化能力（ 560.89±7.22） μm、血浆还原型谷胱甘肽（ 1.34±0.21） μm，对照组体质量指数（ 24.10±1.04） kg/m2、白蛋白（ 40.20±1.20） g/L、球蛋白（ 27.33±1.33） g/L、总抗氧化能力（ 535.41±7.29） μm、血浆还原型谷胱甘肽（ 0.98±0.22） μM，两组相比较，观察组均高于对照组，差异有统计学意义（ t=0.697、 1.021、 1.020、 1.789、 0.691， P<0.05） ;观察组不良反应发生率 9.09%，与对照组不良反应发生率 7.27%差异无统计学意义（ χ2=0.221， P>0.05）。结论 给予慢性阻塞性肺疾病患者抗氧化剂治疗有助于进一步改善其营养状态和抗氧化指标，值得推广使用。  　　 [关键词 ] 慢性阻塞性肺疾病 ;抗氧化剂 ;营养状态 ;抗氧化指标  　　 [Abstract] Objective To observe the effects of antioxidant treatment on nutritional status and antioxidant index in patients with chronic obstructive pulmonary disease. Methods A total of 110 patients with chronic obstructive pulmonary disease who were admitted to our hospital from March 2018 to March 2020 were convenient selected and randomly divided into the control group with conventional treatment and the observation group with antioxidant treatment. The nutritional status， antioxidant status， and incidence of adverse reactions were compared between the two groups. Results After treatment， the body mass index （ 24.91±1.01） kg/m2， albumin （ 43.25±1.25） g/L， globulin （ 30.30±1.35） g/L， total antioxidant capacity （ 560.89±7.22） μm， Plasma-reduced glutathione （ 1.34±0.21） μm， control group body mass index （ 24.10±1.04） kg/m2， albumin （ 40.20±1.20） g/L， globulin （ 27.33±1.33） g/L， the total antioxidant capacity （ 535.41±7.29） μm and plasma-reduced glutathione （ 0.98±0.22） μm were compared between the two groups. The difference was statistically significant （ t=0.697， 1.021， 1.020， 1.789， 0.691， P<0.05） ; the incidence of adverse reactions in the observation group was 9.09%， and the incidence of adverse reactions in the control group was 7.27% （ χ2=0.221， P>0.05） . Conclusion Antioxidant therapy for patients with chronic obstructive pulmonary disease can further improve their nutritional status and antioxidant index， which is worthy of promotion.  　　 [Key words] Chronic obstructive pulmonary disease; Antioxidant; Nutritional status; Antioxidant index  　　慢性阻塞性肺疾病已經成为全球范围内严重威胁患者身心健康及生命安全的常见慢性病之一，好发于 40岁以上人群，特别是在老龄化社会到来后老年人成为该病症的主要发病群体，使得该病症发病率势必会呈现出进一步上升态势 [1]。有研究指出，不良生活习惯为诱发慢性阻塞性肺疾病的独立风险因素之一，起病后又会给患者机体新陈代谢带来不利影响，导致其普遍存在着营养不良以及氧化应激反应，所以补充抗氧化剂十分有必要 [2]。为观察慢性阻塞性肺疾病患者接受抗氧化剂治疗对营养及抗氧化状态的影响效果，该次研究方便选取该院 2017年 3月— 2018年 3月收入的 110例慢性阻塞性肺疾病患者常规治疗与加用抗氧化剂治疗取得的疗效展开对比分析，现报道如下。