简介:Aprimaryhumanrenalcellcarcinomawasdevelopedasaxenograft(NT-25)andmaintainedbyserialtransplantationinnudemice.TheeffectofUFTonthisneogrowthwastestedandevaluatedaswellitsdistributionintheanimaltissues.TheconcentrationofUFTwashigherintumortissuesthanthatinothertissuesandintheanimalexperimentationUFTwasfoundtobeeffectiveonhumanrenalcellcarcinoma.
简介:Introduction:ARationaleforPeerResponseGroupsPeerresponsegroupshavebecomeacommonsightincompositionclassroomsoverthelasttwentyyears.WhileGere(1987)hasdemonstratedthatpeerresponsegroups,inwhichstudentwritersrespondtooneanother’swriting,havealonganddistinguishedpast,thecurrentuseofsuchgroupsemergedoutofthewidespreadadoptionoftheprocessapproachofthe1960’s,whentheywereadvocatedbyanumberofcompositionpractitioners,includingBruffee(1978;
简介:Inthispaper,theSpaceWeatherModelingFramework(SWMF)isusedtosimulatethereal-timeresponseofthemagnetospheretoasolarwindeventonJune5,1998,inwhichtheinterplanetarymagneticfieldshifteditsdirectionfromnorthtosouth.Sincemostcurrentmodelsdonottakeintoaccountconvectiveeffectsoftheinnermagnetosphere,wefirststudytheimportanceofRiceConvectionModel(RCM)intheglobalmodel.Wethenfocusonthefollowingfouraspectsofthemagnetosphere’sresponse:themagnetosphere’sdensitydistribution,thestructureofitsmagneticfieldlines,theareaofthepolarcapboundary,andthecorrespondingionosphericcurrentchange.Wefindthat(1)whentheIMFchangesfromnorthtosouthinthisevent,highmagnetosheathdensityisobservedtoflowdownstreamalongthemagnetopausewiththesolarwind;low-latitudereconnectionatdaysideoccursunderthesouthwardIMF,whilethemagneticfieldlinesinthetaillobecaudal,causedbythenightsidehighlatitudereconnection,extendintotheinterplanetaryspace.Openmagneticfieldlinesexistsimultaneouslyatbothhighandlowlatitudesatthemagnetopause;(2)theareaofthepolarcapisobviouslyincreasediftheIMFturnsfromthenorthtothesouth;thisobservationishighlyconsistentwithempiricalobservations;(3)theionosphericfieldaligncurrentinthenorthernhemisphereisstrongerthaninthesouthernhemisphereandalsoincreasesastheIMFchangesfromnorthtosouth.SWMFwiththeRiceConvectioneffectprovidesreliablemodelingofthemagnetosphericandionosphericresponsetothissolarwindvariation.
简介:Thepatternofprecipitation,includingprecipitationamount,frequencyandintensity,maychangeinthefutureaccordingtothepredictionofclimatechange.Inaridzones,thesoildynamics,plantgrowthandvegetationchange,desertificationandhydrologymightbeaffectedbyprecipitationchange.Ingeneral,theprecipitationinextremearidzoneandaridzoneshowedanincreasetendencywhereastheprecipitationinsomeareainsemi-aridzoneandsub-humidaridzoneshowedadecreasetendency.Theincreaseofprecipitationcouldenhancethegrowthofbiologicalsoilcrust,improvesoilwaterstatus,promoteplantgrowth,increasevegetationcoverage,facilitatethechangefromdesertvegetationtograsslandvegetation,anditisbenefittothereversionoflanddesertification.Inaddition,theincreaseofprecipitationcouldalsoincreasetheriverrunoff,lakestorageandpromotetheoccurrenceofflood,whilethedecreaseofprecipitationhastheadverseeffect.Thesestudieswillbenefitthepredictionofthepossibleresponseofecosystemprocessestothepotentialchangeofprecipitationpatterninaridzonesinthefuture,anditisimportanttotheconservationofnaturalvegetationandthecontrolofdesertification.Morefieldexperimentsandstudiesshouldbeconductedinthefuture,includingtheeffectofincreasedprecipitationortemperature,nitrogendepositionandCO2onsoil,vegetation,desertificationandhydrologyofaridzones,soasthemorepersuasiveresultscouldbeobtainedfromtheseexperimentsandstudies.
简介:Volterraseriesisapowerfulmathematicaltoolfornonlinearsystemanalysis,andthereisawiderangeofnonlinearengineeringsystemsandstructuresthatcanberepresentedbyaVolterraseriesmodel.Inthepresentstudy,therandomvibrationofnonlinearsystemsisinvestigatedusingVolterraseries.Analyticalexpressionswerederivedforthecalculationoftheoutputpowerspectraldensity(PSD)andinput-outputcross-PSDfornonlinearsystemssubjectedtoGaussianexcitation.Basedontheseexpressions,itwasrevealedthatboththeoutputPSDandtheinput-outputcrossPSDcanbeexpressedaspolynomialfunctionsofthenonlinearcharacteristicparametersortheinputintensity.Numericalstudieswerecarriedouttoverifythetheoreticalanalysisresultandtodemonstratetheeffectivenessofthederivedrelationship.TheresultsreachedinthisstudyareofsignificancetotheanalysisanddesignofthenonlinearengineeringsystemsandstructureswhichcanberepresentedbyaVolterraseriesmodel.
简介:Theerrorperformanceofcontimuonsphasemodulation(CPM)withtheoptimalcoherentdetectiondependsonitsminimumsquaredEuclideandistance(MSED).Inthispaper,areduced-statetrellisforfullresponseCPMispresentedundertheconditionthattheMSEDisnotreduced.andthereforethecomplexityoftheViterbidecodingisroduced.
简介:意外怪癖是为高大楼的地震设计的一个非标准的假设。考虑它要求地震抵抗的分析,它要求怪癖的结构的自然颤动的也耗时的计算或由为各怪癖的大小写使用一接近的相等的扭力的时刻发现一个静态的排水量答案。这研究建议一条其他的形式的反应光谱分析(MRSA)途径与意外怪癖计算地震回答。建议途径,把瑞利夸耀称为Projection-MRSA(RRP-MRSA),基于MRSA和二策略被开发:获得怪人的近似模式的快计算的一个RRP方法组织的(a);并且(b)装配怪人的集体矩阵的一条途径组织。RRP-MRSA的效率经由设计例子并且与标准MRSA(ST-MRSA)和一个近似方法相比被测试,即,相等的扭力的时刻混血儿MRSA(ETM-MRSA)。数字结果显示出那RRP-MRSA不仅几乎完成象ST-MRSA的一样的精确,并且比ETM-MRSA好一些,但是也是更节俭的。因此,RRP-MRSA能代替在地震设计的当前的意外怪癖计算。
简介:Viscoelasticityandtemperaturecansignificantlyafecttheperformanceofadielectricelastomer.Inthecurrentstudy,weuseathermodynamicmodeltodescribetheefectoftemperatureandviscoelasticityontheelectromechanicalresponseundergoingacyclicelectricloadbytakingintoaccountofthetemperaturedependentdielectricconstant.Becauseofthesignificantviscoelasticityinthedielectricelastomer,thedeformationandthenominalelectricdisplacementcannotkeepinphasewiththeelectricfieldatlowfrequencies.Theresultsshowthatthemagnitudeofthecyclicelectromechanicalactuationstrainincreaseswiththedecreaseofthetemperatureanddecreaseswiththeincreasingfrequency,andviscoelasticitycanresultinsignificanthysteresisfordielectricelastomersunderarelativelowtemperatureandalowfrequency.
简介:灵活圆形的柱体的导致流动的颤动(FIV)上的集体比率的效果试验性地在一辆拖引的坦克被调查。分别地,有7.9公里和4.8公里的外部、内部的直径的一个Tygon试管为学习被采用。试管被连接到一辆马车并且从休息拖引到一稳定在慢下来在1.6m的距离上再休息在前加快m/s到1.6仍然流水。雷纳兹数字基于柱体,外部直径是80013,000,并且减少的速度(柱体天赋频率使正常化的速度和外部直径)从2~25跨越了。当连接时,柱体在11N的轴的虚荣下面从420公里被伸长到460公里。把伸长的长度基于柱体,方面比率(到外部直径的柱体长度的比率)作为58被计算。三集体比率(柱体的比率结构的质量到代替的液体质量,m*)被分别地用空气,水,和合金粉末(nickel-chromium-boron矩阵合金)填满柱体内部0.7,1.0,和3.4决定。一个光方法为反应大小被采用。多频率颤动在两个被观察同轴(IL)并且跨流动(CF)回答;在高级雷纳兹数字,颤动模式直到3rd在CF反应被识别。模式转变被发现为最高测试的集体比率在更低的减少的速度发生。颤动振幅和频率关于减少的速度被确定并且表示。一个重要减少的颤动振幅与增加集体比率在IL反应被发现,并且仅仅起始、上面的分支在IL和CF反应振幅存在。规范的反应频率被揭示线性地关于减少的速度增加,并且为线性关系的斜坡被发现为测试的三格相同。
简介:无
简介:AIM:TOinvestigatetheimmunogenicityofcandidateDNAvaccineagainsthepatitisCvirus(HCV)deliveredbytwoplasmidsexpressingHCVenvelopeprotein1(El)andenvelopeprotein2(E2)antigensrespectivelyandtostudytheeffectofCpGadjuvantonthiscandidatevaccine.METHODS:RecombinantplasmJdsexpressingHCVEIandE2antigensrespectivelywereusedtosimultaneouslyinoculatemicewithorwithoutCpGadjuvant.AntiserawerethencollectedandtJtersofantJ-HCVantibodieswereanalyzedbyELISA.Onemonthafterthelastinjection,animalsweresacrificedtopreparesingle-cellsuspensionofsplenocytes.ThesecellsweresubjectedtoHCVantigenspecificproliferaionassaysandcytokinesecretionassaystoevaluatethecellularimmuneresponsesofthevaccinatedanimals.RESULTS:AntibodyresponsestoHCVEIandE2antigensweredetectedinvaccinatedanimals.AnimalsreceivingCpGadjuvanthadslightlylowertitersofanti-HCVantibodiesinthesera,whilethesplenocytesfromtheseanimalsshowedhigherHCV-antigenspecificproliferation.Analysisofcytokinesecretionfromthesplenocyteswasconsistentwiththeaboveresults.Whilenoantigen-specificIL-4secretionwasdetectedforallvaccinatedanimals,HCVantigen-specificINF-γ,secretionwasdetectedforthesplenocytesofvaccinatedanimals.CpGadjuvantenhancedthesecretionofINF-γ,butdidnotchangetheprofileofIL-4secretion.CONCLUSION:VaccinationofmicewithplasmidsencodingHCVE1andE2antigensinduceshumoralandcellularimmuneresponses.CpGadjuvantsignificantlyenhancesthecellularimmuneresponse.
简介:无
简介:Thymopentinderivative(septapeptide)waspreparedbymeansofthesolid-phasepeptidesynthesismethodinwhichstepwiseandsegmentcondensationswereinvolved.ThestructuresofthekeyintermediateandtargetmoleculewereconfirmedbyESI-MS,elementaryanalysis,IR,1HNMRand13CNMRspectrometriesinourexperiments.Inthisstudy,theauthorsfoundthatboththymopentinderivetive(septapeptide)andthymopentincouldpromoteTcellproliferationandincreaseofE-rosefomationcells.
简介:AccumulatingevidencehasdemonstratedthatregulatoryT(Treg)cellsplayanimportantroleinthemaintenanceofimmunologicself-toleranceandindown-regulatingvariousimmuneresponses.Thus,therehasrecentlybeenanincreasinginterestinstudyingthebiologyofTregcellsaswellastheirpotentialapplicationintreatingimmunediseases.ManytypesofTregcellsubsetshavebeenreportedinavarietyofdiseasemodels.Amongthesesubsets,αβ-TCR+CD3+CD4-CD8-doublenegative(DN)TregcellsaredefinedbytheircapabilityofinhibitingimmuneresponsesviadirectlykillingeffectorTcellsinanantigenspecificfashion.Furthermore,DNTregcellshavebeenshowntodevelopregulatoryactivityafterencounteringspecificantigens,partiallymediatedbytheacquisitionofMHC-peptidecomplexesfromantigenpresentingcells(APCs).ThepresentationofacquiredalloantigensonDNTcellsallowsforthespecificinteractionbetweenDNTregcellsandalloantigenreactiveeffectorTcells.OncetheDNTregandtargetcellshavecomeintocontact,killingisthenmediatedbyFas/Fas-ligandinteractions,andperhapsthroughotherunidentifiedpathways.Furthercharacterizationofthefunctions,molecularexpressionandmechanismsofactivationofDNTregcellswillhelpinthedevelopmentofnoveltherapiestoinduceantigenspecifictolerancetoselfandforeignantigens.Cellular&MolecularImmunology.2004;1(5):328-335.