简介：AbstractBackground:Leukocyte telomere length shortening is a characteristic of premature senescence, a process that can be accelerated by oxidative stress. In general, patients with end-stage renal disease undergoing regular hemodialysis (HD) are repeatedly exposed to oxidative stress. Patients undergoing HD tend to have cardiovascular diseases associated with oxidative stress and inflammation. Therefore, we assumed that telomere length is associated with HD vintage and the degree of vascular calcification.Methods:A total of 144 patients undergoing regular HD before kidney transplantation and 62 patients on hemodialysis, but not undergoing kidney transplantation, were enrolled. We measured common laboratory values, such as calcium, phosphate, and hemoglobin levels, and assessed the degree of vascular calcification in the patients. The leukocyte telomere length was measured using reverse transcription polymerase chain reaction, and Spearman correlation was used for correlation analysis.Results:The leukocyte telomere length was negatively associated with age (rho = -0.306, P <0.01); it was shorter in middle-aged patients than in young patients (13.48 ± 4.80 vs. 15.86 ± 4.51, P < 0.01). The telomere length was significantly different among patients aged 52-74 years in groups with different HD vintages. Additionally, the telomere length was positively associated with serum hemoglobin (Hb) levels in all patients (rho = 0.290, P < 0.01). There was a significant difference among patients divided into three groups according to the degree of anemia (17.09 ± 5.64 vs. 14.40 ± 4.07 vs. 13.99 ± 3.95, P < 0.01). Further, a significant difference was observed in the telomere length among patients with different degrees of vascular calcification (16.79 ± 4.91 vs. 13.61 ± 2.82 vs. 14.62 ± 3.63 vs. 10.71 ± 3.74, P < 0.01). The telomere length was shorter in the patients on hemodialysis who did not receive a kidney transplant than in the surgical patients (8.12 ± 1.83 vs. 14.33 ± 4.63, P < 0.01).Conclusion:This study demonstrated that the telomere length was significantly correlated with HD vintage in patients of a certain age group. The telomere length was shorter in patients on hemodialysis who matched for age and dialysis vintage with kidney transplant patients. It was also associated with vascular calcification and serum Hb levels in all patients undergoing HD.

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简介：Objective:ToinvestigatethedynamicsofplasmacAMP/Cgmpinpatientsduringcardiacsurgery,anditsrelationshiptotraumaticstress.Methods:Sixteenpatients,aged19.31years±10.4years,whounderwentanopenheartoperationwithcardiopulmonarybypass(CPB)andhypothermiawereservedassubjects.Thearterialplasmaconcentrationsofcyclicadenosinemonophosphate(Camp)andcyclicguanosinemonophosphate(Cgmp)weremeasuredbyradioimmunoassay2hoursbeforeoperation,afterheparinization,20minutesfollowingCPB,attheendoftheoperation,and24and72hourspostoperatively,respectively.Thepatients'preoperativebloodsampleswereheparinizedandthevenousbloodsamplesof30healthyblooddonorsweretakentomeasurethelevelsofCampandcGMPasheparinandnormalcontrolsseparately.Results:Therewerenostatisticaldifferenceamongtheheparincontrol,preoperativelevelandnormalcontrol.ThepeakvaluesofCampandCgmpoccurredduringCPBandplasmaCamplevelschangedsynchronouslywithintensitiesofoperativestimulustohumanbody.HowevercGMPlevelwasmainlyrelatedtotheoperativestimulustotheheartandCPB.TheCampvaluewaspositivelycorrelatedwiththeCgmpvalue(r=0.6313,P＜0.001).Conclusions:Dynamicvariationofplasmacyclicribonucleotidecanbeconsideredasareferenceparameterforintensityoftraumaticstress.

简介：目的：探讨针刺对单纯性肥胖症患者胰岛素抵抗的调节作用与临床疗效。方法：采用“益气健脾，化痰消浊”法，取脐周八穴（天枢、滑肉门、外陵、阴交、水分）、关元、足三里等穴，配合耳穴贴压，并与同期30例健康体检者比较，观察针刺前后单纯性肥胖症患者FBG、INS、ISI、TC、TG、LDLC、HDLC变化；观察针刺前后单纯性肥胖症患者腰围、臀围、腰臀比、体重、BMI的变化，及其Ⅰ度肥胖、Ⅱ度肥胖的疗效差异。结果：治疗前单纯性肥胖症患者存在高胰岛素血症（HI），ISI显著下降（P〈0．01），治疗后腰围、臀围、腰臀比、体重、BMI明显下降职0．05，P〈0．01），同时FBG、INS、TC、TG、LDLC亦明显下降（P〈0．01，P〈0．05），ISI、HDLC明显上升（P〈0．05）。结论：针刺治疗不仅能有效改善单纯性肥胖症患者的体脂参数，同时也能调整单纯性肥胖症患者异常脂质代谢，改善胰岛素抵抗状态。

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简介：Objective:ToelucidategeneralcharacteristicsofHIV/AIDSpatientsseekingcareatDitanHospitalinanattempttoguideearlydiagnosisinroutinemedicalcare.Materialsandmethods:Aretrospectiveanalysisof185HIV/AIDScasesfromJanuary1990toJune2002wascompletedusingSPSSstatisticalanalysis.Results:Maletofemaleratiowas1.8:1.Subjectsrangedinagefrom1yearoldto64yearsold.16caseswereyoungerthan20yearsoldwiththemedianageamongtheyoungersubsetat7.7years.169caseswereolderthan20yearsoldwithamedianageof36yearsold.29%ofthesubjectswerepeasants.Theremaining71%,wereofotherunspecifiedoccupations.90.8%ofindividualswereofHandescentwhile3.7%ofindividualswereofaminorityheritage.50.3%ofsubjectsweremarried;23.8%havenevermarried;8.1%weredivorced;andtheremaining17.8%wereofunknownmaritalstatus.Ofthoserepresentedinthisstudy,36.8%camefromtheHenanprovince;17.8%werefromBeijing;8.6%werefromShanxi;31.4%fromtheother20provincesofChina;and5.4%fromoutsideofChina.Modeoftransmission:40.0%(74/185)contractedHIVthroughunprotectedsexualcontact;29.2%(54/185)throughreceivingbloodorplasmatransfusions;21.1%(39/185)throughdonatingplasma;7caseswereintravenousdrugusers;7caseswereverticallytransmitted.Modeoftransmissionwasunknownin4cases.Clinicalcategories:Anincluded45cases;Bincluded85cases:Cconsistedof76cases.12casesweredeceased.Initialpresentation:39casespresentedwith_fever,coughanddiarrhea.37caseshadfeverandcoughonly-38casespresentedwithchronicdiarrhea.16caseswerediscoveredincidentallyattimeofoperation.8casespresentedwithfungalinfectionoftheoralcavityorinesophagus.ThecommonHIVassociatedsymptomsandopportunisticinfectionswere:weightlossanddiarrhea,respiratorydiseases,dermatologicdiseases,anemia,neutropenia.Diseasesofotherorgansystemswerelesscommon.Commonmisdiagnosesincluded

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简介：Inordertoacknowledgethemulti-infectiondataofSTDpatientsandimprovetheprophylaxisandtherapyforSTDs，297patientsand30healthypeoplewereexaminedusingtheHSV-2plasmaantibody．TheresultsshowedthatallkindsofSTDpatientswereinfectedbyHSV-2indifierentratios．thehighestratiooccurringinsyphilispatients．

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简介：AbstractBackground:The association between free triiodothyronine (FT3) and long-term prognosis in dilated cardiomyopathy (DCM) patients has not been evaluated. The purpose of this study was to determine whether the level of FT3 could provide prognostic value in patients with DCM.Methods:Data of consecutive patients diagnosed with DCM were collected from October 2009 to December 2014. FT3 was measured by fluoroimmunoassay. Other biochemical markers, such as free thyroxin (FT4), thyroid-stimulating hormone, red blood cell, hemoglobin, blood urea nitrogen, and serum creatinine, were tested at the same time. Follow-up was performed every 3 months. The primary endpoint was all-cause mortality. Pearson analysis was used to evaluate the correlation of FT3 and other lab metrics with DCM patients’ prognosis. The association of long-term mortality in DCM and FT3 was compared using Cox hazards model.Results:Data of 176 patients diagnosed with DCM were collected. Of them, 24 patients missed FT3 values and six patients were lost to follow-up. Altogether, data of 146 patients were analyzed. During the median follow-up time of 79.9 (53.5-159.6) months, nine patients lost, 61 patients died (non-survival group), and 85 patients survived (survival group). FT3 was significantly lower in non-survival group than that in survival group (3.65 ± 0.83 pmol/L vs. 4.36 ± 1.91 pmol/L; P = 0.003). FT3 also showed a significantly positive correlation with red blood cell and hemoglobin, negatively correlated with age, blood urea nitrogen and serum creatinine (P < 0.05), respectively. Patients in the group of lower FT3 levels (FT3 ≤ 3.49 pmol/L) suffered from a higher risk of all-cause mortality (P for log-rank = 0.001). In multivariate Cox regression analysis, FT3 level was significantly associated with all-cause mortality (hazard ratio: 0.70, 95% confidence interval 0.52-0.95, P for trend = 0.021).Conclusion:Low levels of FT3 were associated with increased all-cause mortality in patients with DCM.

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简介：Objective:Toanalyzeretrospectivelytheclinicalsymptoms,signs,radiologicalfindingsandresultsoftreatmentofposttraumaticsyringomyelia.Methods:Thedataof7patientswithposttranmaticsyringomyeliaconfirmedbycomputerizedtomography(CT)andmagneticresonanceimaging(MRI)inourhospitalbetween1999and2004werereviewedretrospectively.Thepatientsunderwentdecompressivelaminectomyorsyringo-subarachnoid(S-S)shuntingwithmicrosurgery.Long-termfollow-upwasavailable(range:13-65months).Results:Themajorclinicalmanifestationsofposttraumaticsyringomyefiausuallyincludedtheonsetofincreasingsignsandthedevelopmentofnewsymptomsafteranapparentlystableperiod.Theclinicalsymptomsincludedpain,sensorydisturbance,weakness,andproblemsinautonomicnerves.Syrinxexistedmerelyatthecervicallevelin4casesandextendeddownwardtothethoraciclevelsintheother3cases.Onecaseunderwentdecompressivelaminectomy,6casesweretreatedbyS-Sshunting.Duringtheearlypostoperativeperiod,allthepatientsshowedanimprovementofsymptomsofsyrinxwithoutmajorcomplicationordeath.ThedecreasedsizeorcollapseofthesyrinxwasdemonstratedbypostoperativeMRI.Conclusions:Posttraumaticsyringomyeliaisadisablingsequelaofspinalcordinjury,developingmonthstoyearsafterspinalinjury.MRIisthestandarddiagnostictechniqueforsyringomyelia.Thepatientswithposttraumaticsyringomyeliacombinedwithprogressiveneurologicaldeteriorationshouldbetreatedwithoperations.S-Sshuntingprocedureiseffectiveinsomepatientswithposttraumaticsyringomyelia.Decompressiveproceduremaybeanalternativeprimarysurgicaltreatmentforpatientswithkyphosisandcordcompression.

简介：Objective:　Tostudytheclinicalfeaturesofcraniocerebralinjury(CI)intheaged.　　Methods:　Thedataof149oldpatientswithCIhospitalizedinthedepartmentfromJuly1991toMay2000werestudiedretrospectivelyinthisstudy.Thecausesofinjury,traumaticpathology,clinicalmanifestationandcausesofdeathwereanalyzed,too.　　Results:　Automobileswerethemainvictim-makers,andfallswerethesecond.Andtherewasnosignificantdifferencebetweenthefirsttwokindsofvictim-makers.Thepatientssufferedmainlyfromcerebralcontusion,intracerebralhematomasandsubduralhematomas,andrelativelyfewerfromepiduralhematomas.ThescoresofGlasgowComaScale(GCS)wererelatedcloselytotheprognosiswhenhospitalizedorbeforesurgicaltreatment.Thetotalmortalityratewas37.5%inthisstudy.Themaincauseofdeathwasbraininjury.　　Conclusions:　TheoldpatientswithCIhaveahighmortalityrate.Andthecausesofinjury,traumaticpathologyandclinicalmanifestationarepeculiarintheaged.

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简介：Objective:Implantableportthrombosis(IPT)incancerpatientsisarelativelyrarebutseverecomplication.Severalfactorsarereportedlyassociatedwiththeoccurrenceofthrombosis.WeaimedtodescribetheprevalenceandtheanatomoclinicalfeaturesofIPTobservedincancerpatientswhoweretreatedinamedicaloncologydepartmentinTunisia.Methods:Atotalof600cancerpatientswhohadportimplantationfromJanuary2013toDecember2015wereretrospectivelyidentified.Caseswithsymptomatic/incidentalIPT(radiologicallyconfirmed)werefurtheridentified.Epidemiologicalandanatomoclinicalfeatureswerecollectedfrompatientrecordsandthedepartmentdatabase.Results:Weobservedthat33ofthe600patientshadIPT;thus,theprevalencewas5.5%.Themedianagewas57years,andthegenderratiowas0.43.Overweightorobesitywasobservedin73%ofthepatients.IPToccurredmainlyinpatientswithbreast(36.4%)andcolorectal(33.3%)cancers,whichweremostlynonmetastatic(79%).Atleastoneidentifiedclassicalthromboembolicriskfactorwasfoundin13patients(smokingin9,tamoxifenin2).IPTwassymptomaticin93%ofthecases,occurringwithinanaveragetimeof56days.Implantableportswereremovedbecauseofinfectionin2casesandnonfunctionalityin3cases.IPTtreatmentwasbasedonlow-molecular-weightheparins(94%)andantivitaminK(6%)foranaverageof130days.Fourpatientshadpost-therapycomplications:onethrombosisrecurrenceandthreeinfections.Conclusions:IPTcasesinthe600patientswereobservedtooccurinobesenonmetastaticcancerpatientswithinthefirst3monthsafterIPimplantation.

简介：针刺内关．足三里．乳根和肩贞穴．温灸膻中．治疗了62例产后缺乳患者。经7次治疗．30例产妇乳汁分泌每天400mL以上．精神饱满；26例乳汁分泌每天250mL左右．需补充牛奶喂养婴儿；6例乳汁分泌无明显改善．挤压双侧乳房极少量乳汁分泌。

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