The　effects　of　sodium　hyaluronate　on　mRNA　expressions　of　matrix　metalloproteinase-1,-3　and　tissue　inhibitor　of　metalloproteinase-1　in　cartilage　and　synovium　of　traumatic　osteoarthritis　model-中国期刊网

摘要 Objective:Toobservetheinfluenceofintra-articularinjectionofsodiumhyaluronate(HA)onthemRNAexpressionsofmatrixmetalloproteinase-1,-3(MMP-1,-3)andtissueinhibitorofmetalloproteinase-1(TIMP-1)incartilageandsynoviumoftraumaticosteoarthritis(OA).Methods:Sixteenwhiterabbitsunderwentunilateralanteriorcruciateligamenttransection(ACLT)weredividedinto2groupsrandomly5weeksaftertransection.Theexperimentalgrouprabbitsreceived0.3mlof1%HAbyintra-articularinjectiononceaweek.Animalsinthecontrolgroupweretreatedunderthesameconditionsusingphysiologicalsaline.Tenweeksfollowingsurgery,cartilageandsynoviumwereharvested.ThemRNAexpressionsofMMP-1,MMP-3andTIMP-1wereanalyzedusingreversetranscription-polymerasechainreaction(RT-PCR).Results:Insynovium,themRNAexpressionofMMP-3wassuppressedintheHAinjectiongroup.HAtreatmenthadnoeffectontheMMP-3expressionincartilage.NosignificantdifferenceofMMP-1andTIMP-1expressionsincartilageandsynoviumwasfoundbetweentheHAinjectiongroupandthecontrolgroup.Conclusions:OneofthemechanismsofthetherapeuticeffectofHAmaybetheinhibitionofexpressionofMMP-3insynoviumduringearlystageoftraumaticOA.

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The　effects　of　sodium　hyaluronate　on　mRNA　expressions　of　matrix　metalloproteinase-1,-3　and　tissue　inhibitor　of　metalloproteinase-1　in　cartilage　and　synovium　of　traumatic　osteoarthritis　model

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The effects of sodium hyaluronate on mRNA expressions of matrix metalloproteinase-1,-3 and tissue inhibitor of metalloproteinase-1 in cartilage and synovium of traumatic osteoarthritis model

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The　effects　of　sodium　hyaluronate　on　mRNA　expressions　of　matrix　metalloproteinase-1,-3　and　tissue　inhibitor　of　metalloproteinase-1　in　cartilage　and　synovium　of　traumatic　osteoarthritis　model

同分类资源更多