A novel advanced glycation endproducts breaker restores cardiovascular dysfunctions in experimental diabetic rats-中国期刊网

摘要 AIMTheformationofadvancedglycationendproducts(AGEs)onconnectivetissueandmatrixcomponentsleadstoincreasesincollagencrosslinkingthatcontributestoaorticandmyocardialstiffnessinnormalagingandwhichoccursatanacceleratedrateindiabetes.Inthisstudy,weexaminedtheeffectsofanovelAGEsbreaker,C36,oncardiovasculardysfunctionsinexperimentaldiabeticrats.METHODSandRESULTSMaleWiatarratsweremadediabeticbyi.p.injectionof70mg/kgstreptozotocin.After12weeksofdiabetes,theanimalswererandomlydividedinto4groups(n=8-11),

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A novel advanced glycation endproducts breaker restores cardiovascular dysfunctions in experimental diabetic rats

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A novel advanced glycation endproducts breaker restores cardiovascular dysfunctions in experimental diabetic rats

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