AIMTheformationofadvancedglycationendproducts(AGEs)onconnectivetissueandmatrixcomponentsleadstoincreasesincollagencrosslinkingthatcontributestoaorticandmyocardialstiffnessinnormalagingandwhichoccursatanacceleratedrateindiabetes.Inthisstudy,weexaminedtheeffectsofanovelAGEsbreaker,C36,oncardiovasculardysfunctionsinexperimentaldiabeticrats.METHODSandRESULTSMaleWiatarratsweremadediabeticbyi.p.injectionof70mg/kgstreptozotocin.After12weeksofdiabetes,theanimalswererandomlypidedinto4groups(n=8-11),
