1-methyl-4-phenylpyridinium ion induces endoplasmic reticulum stress through glycogen synthase kinase-3 beta activation in PC12 cells-中国期刊网

摘要 1-methyl-4-phenylpyridiniumion(MPP+)inducesendoplasmicreticulumstressandactivatescaspase-12inPC12cells,leadingtoneuronalapoptosis.However,theunderlyingmolecularmechanismremainsunknown.Thepresentstudyinvestigatedtheregulatoryeffectsofnervegrowthfactor(Aktactivator)andlithiumchloride(glycogensynthasekinase-3βinhibitor)ontheendoplasmicreticulumstresssignalingpathway.TheresultsrevealedthatMPP+inducedexpressionofBipandC/EBPhomologousprotein.TheupregulationofBipandC/EBPhomologousprotein,aswellasthedecreasedpro-caspase-12levelinducedbyMPP+wereinhibitedbypretreatmentofthenervegrowthfactororlithiumchloride.Theseresultssuggestthatthephosphatidylinositol3kinase-Akt-glycogensynthasekinase-3βpathwayisinvolvedinMPP+-inducedendoplasmicreticulumstress.

1Long-xing Xue;Hong-yu Liu;Yang Cui;Yue Dong;Jiao-qi Wang;Qiu-ye Ji;Jin-ting He;Min Yao;Ying-ying Wang;Yan-kun Shao;Jing Mang;Zhong-xin Xu. Neuroprotective effects of Activin A on endoplasmic reticulum stress-mediated apoptotic and autophagic PC12 cell death.神经病学与精神病学,2017-05.
2Cao Zhao-Hui,Wu Zhuan,Hu Cong,Zhang Min,Wang Wu-Zhou,Hu Xiao-Bo. Endoplasmic reticulum stress and destruction of pancreatic β cells in type 1 diabetes.医药卫生,2020-08.
3Yuanyuan Xuan,Shiyun Chen,Xin Ding,Lexun Wang,Shengwen Li,Guizhi Yang,Tian Lan. Tetrahydropalmatine attenuates liver fibrosis by suppressing endoplasmic reticulum stress in hepatic stellate cells.医药卫生,2022-12.
4Rong-Yang Dai;Yao Chen;Jing Fu;Li-Wei Dong;Yi-Bin Ren;Guang-Zhen Yang;You-Wen Qian;Jie Cao;Shan-Hua Tang;Sheng-Li Yang;Hong-Yang Wang. p28^GANK inhibits endoplasmic reticulum stress-induced cell death via enhancement of the endoplasmic reticulum adaptive capacity.细胞生物学,2009-11.
5Chih-Li Lin. Attenuation of endoplasmic reticulum stress as a treatment strategy against ischemia/reperfusion injury.神经病学与精神病学,2015-12.
6Yiyuan Yuan;Xiang Gao;Ning Guo;Hui Zhang;Zhiqin Xie;Meilei Jin;Baoming Li;LeiYu;Naihe Jing. rSac3, a novel Sac domain phosphoinositide phosphatase, promotes neurite outgrowth in PC12 cells.细胞生物学,2007-11.
7Lorenzo Romero-Ramírez;Manuel Nieto-Sampedro;M.Asunción Barreda-Manso. All roads go to Salubrinal：endoplasmic reticulum stress,neuroprotection and glial scar formation.神经病学与精神病学,2015-12.
8YANGSu-Fen;WUZhong-Jun;YANGZheng-Qin;LIYu;WuQin;ZHOUQi-Xin;SHIJing-Shan. Protective Effect of Eecdysterone on the PC12 Cell CytotoxicityInduced by beta-amyloid 25-35.药学,2004-02.
9Di Cuixia;Zhang Hong;Han Lu. 3 - 80 PCBP1 Induces Apoptosis in Cervical Cancer HeLa Cells Exposed to Carbon Ion Beam Irradiation.物理,2013-01.
10JIARUIWU. Activation of p53 in gastric cancer cells by tripchlorolide specifically induces apoptosis.细胞生物学,2002-03.

1-methyl-4-phenylpyridinium ion induces endoplasmic reticulum stress through glycogen synthase kinase-3 beta activation in PC12 cells

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1-methyl-4-phenylpyridinium ion induces endoplasmic reticulum stress through glycogen synthase kinase-3 beta activation in PC12 cells

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