ObjectiveTostudyeffectsofJiangtangFanglongWan(glucose-loweringanddeafness-preventingcapsule)onhearinginananimalmodelofdiabetes.MethodsWistarratswereusedtocreateadiabetesmodelbyintraperitonealinjectionofstreptozotocin(STZ,55mg/kg).FortyratswererandomlyselectedtoreceiveJiangtangFanglongWan(10g/kg/day)throughintragastricgavage(treatmentgroup)ornormalsaline(controlgroup).Auditorybrainstemresponses(ABRs)wererecordedatMonths1,2and3.ResultsABRlatenciesandwaveintervalsweresimilarbetweenthetwogroupsatMonth1(P>0.05).ABRlatenciesandwaveintervalswereshorterinthetreatmentgroupthanthoseofthecontrolgroupatMonths2and3(P<0.05andP<0.01,respectively).ConclusionOurresultssuggestthatJiangtangFanglongWanmayhaveabeneficialeffectinpreventingandtreatinghearingimpairmentassociatedwithdiabetes.
