Gold-catalyzed oxazoles synthesis and their relevant antiproliferative activities

(整期优先)网络出版时间:2013-12-22
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Nine5-aryl-2-methyloxazolederivativesweresynthesizedviagold-catalyzedalkyneoxidation.AllofthecompoundshavebeenscreenedfortheirantiproliferativeactivitiesagainstMCF-7cell(humanbreastcarcinoma),A549cell(humanlungcarcinoma)andHelacell(humancervicalcarcinoma)linesinvitro.Theresultsrevealedthatcompounds1b,1cand1dexhibitedstronginhibitoryactivitiesagainsttheMCF-7celllines(withIC50valuesof4.6,9.7and2.2mmol/L,respectively).