Enhanced External Counterpulsation Inducing Arterial Hemodynamic Variations and Its Chronic Effect on Endothelial Function

Tomakecleartheprecisehemodynamicmechanismunderlyingtheanti-atherogenesisbenefitofenhancedexternalcouterpulsation(EECP)treatment,andtoinvestigatetheproperroleofsomeimportanthemodynamicfactorsduringtheatheroscleroticprogress,acomprehensivestudycombininglong-termanimalexperimentandnumericalsolvingwasconductedinthispaper.AnexperimentallyinducedhypercholesterolemicporcinemodelwasdevelopedandthechronicEECPinterventionwassubjected.Basichemodynamicmeasurementwasperformedinvivo,aswellasthearterialendothelialsampleswereextractedforphysiologicalexamination.Meanwhile,anumericalmodelwasintroducedtosolvethecomplexhemodynamicfactorssuchasWSSandOSI.TheresultsshowthatEECPtreatmentresultedinsignificantincreaseoftheinstantlevelsofarterialWSS,bloodpressure,andOSI.DuringEECPtreatment,theinstantOSIlevelofthecommoncarotidarteriesovercardiaccyclesraisedtoameanvalueof8.58×10-2±2.13×10-2.Meanwhile,thechronicinterventionofEECPtreatmentsignificantlyreducedtheatheroscleroticlesionsinabdominalaortasandtheendothelialcellularadherence.ThepresentstudysuggeststhattheuniquebloodflowpatterninducedbyEECPtreatmentandtheaugmentationofWSSlevelincardiaccyclesmaybethemostimportanthemodynamicmechanismthatcontributetoitsanti-atherogenesiseffect.Andasoneoftheindicesthatcausegreatconcernincurrenthemodynamicstudy,OSImaynotplayakeyroleduringtheinitiationofatherosclerosis.更多还原