BackgroundAdvancedpracticenursetransitionalcarehasbeenproofedtobeimportantforolderadultswithchronicconditions.However,sucheffectivenesshasneverbeenstudiedinthemanagementofappropriateWarfarinuseinclinicalpractice.MethodsAtotalof97patientswererandomlydistributedintocontrolgroupwhoreceivedusualcare,andinterventionalgroupwhoreceivedtransitionalcareprovidedbyAPNs.A12-monthobservationofbothgroupswererecordedbyphysiciansandAPNsandtheimpactofAPNsonthemanagingofWarfarintherapywasalsoevaluatedbasedontimeinthetherapeuticrange(TTR).ResultsAPNstransitionalcaresignificantly(P<0.01)improvedpatients’adherence,increasedTTRandhighTTRratiocomparedwithcontrolgroup.Re-admissionduetostrokewassignificantly(P<0.01)reducedbyAPNstransitionalcare.ConclusionAPNstransitionalcareimprovespatients’knowledgeonAFandreducesstrokerisk.ThecurrentresearchstronglysuggestthenecessityofAPNstransitionalinterventionalinmanaginganticoagulationtherapyinAFpatientsinChina.