Analysis of chloramphenicol in honey by on-line pretreatment liquid chromatography-tandem mass spectrometry

(整期优先)网络出版时间:2015-01-11
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Chloramphenicolisanantibioticandoneofthepotentialcontaminantsinhoney.Solid-phaseextractionisthekeypretreatmentprocedureforanalysisofchloramphenicolinhoney.Inthiswork,anon-linepretreatmentliquidchromatography-tandemmassspectrometersystemforsensitive,reliableandhigherthroughputanalysiswasdeveloped.Withthemethylcellulose-immobilizedreversed-phasecolumn,sugarsinahoneysamplewereefficientlyremovedin1min.Asaresult,thelimitofquantitationofchloramphenicolwas20pg/mL(0.2μg/kghoney).