The roles of tubulin-folding cofactors in neuronal morphogenesis and disease

(整期优先)网络出版时间:2015-09-19
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Microtubulesplayimportantrolesinneuronalmorphogenesis,includingcellularpolarization,neuritegrowth,andbranching.Amicrotubuleisapolymerofα-andβ-tubulinheterodimersthatareformedbyamultistepprocessassistedbyatleastfivetubulin-foldingcofactors(TBCA–E)(Lopez-Fanarragaetal.,2001).Newlysynthesizedα-andβ-tubulinsassociatewiththecytosolicchaperonincomplex(CCT),andthenthequasi-nativetubulinsinteractwith