Inthispaper,westudytheCauchyproblemforthe3DgeneralizedNavier-Stokes-Boussinesqequationswithfractionaldiffusion:{ut+(u·▽)u+v∧2αu=-▽p+θe(3),e3=(0,0,1)T,θt+(u·▽)θ=0,Dicu=0.Withthehelpofthesmoothingeffectofthefractionaldiffusionoperatorandalogarithmicestimate,weprovetheglobalwell-posednessforthissystemwithα≥5/4.Moreover,theuniquenessandcontinuityofthesolutionwithweakerinitialdataisbasedonFourierlocalizationtechnique.Ourresultsextendonesonthe3DNavier-Stokesequationswithfractionaldiffusion.