Not only a bad guy:potential proneurogenic role of the RAGE/NF-κB axis in Alzheimer's disease brain

(整期优先)网络出版时间:2016-12-22
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Thereceptorforadvancedglycationendproducts(RAGE)isareceptoroftheimmunoglobulinsuperfamilyofcellsurfacemoleculeswhichplaysimportantcontributionsunderbothphysiologicalandpathologicalconditions.OvertheyearsextensiveresearchworksupportedthedetrimentalroleofRAGEinAlzheimer’sdisease(AD)pathophysiology,rangingfromitsinvolvementinbetaamyloid(Aβ)braininfluxandclearance,