InthisLetter,aminiaturewearableRamanspectroscopysystemisdeveloped.Awearablefiber-opticprobeiemployedtohelpthestableandconvenientcollectionofRamanspectra.Anonlinearpartialleastsquaresmodebasedonamultivariatedominantfactorisemployedtopredicttheglucoselevel.Themeancoefficientsofdeterminationare0.99,0.893,and0.844fortheglucosesolution,laboratoryrats,andhumanvolunteers.ThresultsdemonstratethataminiaturewearableRamanspectroscopysystemisfeasibletoachievethenoninvasivdetectionofhumanbloodglucoseandhasimportantclinicalapplicationvalueindiseasediagnosis.
