1.IntroductionWiththeincreaseinolderpopulationsworldwide1comesanincreasedhealthburdenrelatedtochronicdiseases.2–4Oneofthemostdisablingoftheseiskneeosteoarthritis(OA),whichoccursinmillionsofolderadultswhosubsequentlylivewithjointpainandstiffness,leadingtochronicdisabilityandadiminishedqualityoflife.5,6EpidemiologicalevidenceshowsahigherprevalenceofOAinolderadultslivinginurbanandrural